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BACKGROUND: Achalasia is a rare motility disorder of the esophagus. The diagnosis involves clinical suspicion based on history details and results of high-resolution manometry (HRM) as recommended by the Chicago classification (CCv4.0). Interpreting data obtained through HRM can be complex especially for the novice user.METHODS: We propose therefore a color-based algorithm involving the "reversed
Background: There are currently no molecular tests to identify individual breast cancers where radiotherapy (RT) offers no benefit. Profile for the Omission of Local Adjuvant Radiotherapy (POLAR) is a 16-gene molecular signature developed to identify low-risk cancers where RT will not further reduce recurrence rates. Methods: An individual participant data meta-analysis was performed in 623 patien
Aim of the review: To provide an overview of studies that have published dataregarding region and population size, procedure location, team composition, inclusionand exclusion criteria, outcome parameters, and cost–benefit analyses onextracorporeal membrane oxygenation use for refractory out-of-hospital cardiac arrest.Data sources: A structured systematic literature search of articles published pr
Remission is emerging as a feasible treatment goal in moderate-to-severe asthma, driven by the success of biologic therapies in controlling inflammation and reducing exacerbations. Yet current definitions of remission—focused on symptom control, lung function, and corticosteroid reduction—lack precision, can only be ascertained retrospectively, and do not reflect the underlying mechanisms and path
Health-related quality of life (HRQoL) has been shown to predict overall survival (OS) in several different malignancies, but not in patients with small intestinal neuroendocrine tumours (siNET). We evaluated the influence of HRQoL on survival in patients with siNET. We included 85 patients with advanced siNET who completed the validated HRQoL instruments, EORTC QLQ-C30 and GI.NET21. We used Cox p
Urban areas provide a promising context for upcycling due to the concentration of consumers and existence of bulky waste resources. Hence, upcycling initiatives emerge across European cities, but little is known about their manifestations. Building on interviews with twenty-four stakeholders from the urban upcycling ecosystem and three focus groups sessions, a morphological model was created with
Background: Detecting and monitoring monoclonal free light immunoglobulin chains in serum is important for managing patients with B-cell neoplasms. Established methods have relied on immunochemistry, with monoclonality determined through an abnormal ratio of free kappa and lambda chains and an increased concentration of the involved chain. This indirect approach has limitations. Mass spectrometric
Performance featuring spherical amplification.Aktionshalle Stanzerei, Baden (CH)Ensemble für neue Musik Zürich06/11/2024From the Program:Haas, Lorenz (*1968, CH) – Nichts Schöneres (a Schumann song recital in fourteen scenes for seven instruments and voice) [2024]
The aim of this study was to assess to what extent receptive vocabulary could be explained by morphological knowledge, language majority/minority background and socioeconomic status (SES) for Swedish 8–11-year-old children. A total of 89 children participated, of whom n = 47 were L1 speakers (language majority) and n = 42 were L2 speakers (language minority). Morphological knowledge (MK) was asses
Background: Kidney transplant recipients after kidney transplantation may develop transplant renal artery stenosis (TRAS). Multiple studies have sought to identify risk factors, yet the findings remain inconsistent. Methods: PubMed, Scopus, and Web of Science Core Collection were comprehensively searched to retrieve studies. The 1st screening phase required studies to be in English and evaluate pa
Hållbarhetskommunikation tar sig an några av samhällets mest angelägna och komplexa utmaningar. Denna avhandling fördjupar området genom att lyfta fram komplexitet som ett definierande kännetecken för strategisk hållbarhetskommunikation, ett perspektiv som i stort sett har försummats. Den utmanar den dominerande organisationscentriska ansatsen som betraktar kommunikation som ett medel för att uppnSustainability communication confronts some of society’s most pressing and complex challenges. This thesis advances the field by highlighting complexity as a defining characteristic of strategic sustainability communication, a perspective that has been largely neglected. It challenges the dominant organization-centric approach that frames communication as an instrument for achieving corporate goal
The technical development, involving digitalization, artificial intelligence, automation, and machine learning, can challenge the current tax system and consequently the means to finance public sector activities in several ways. If technology replaces labor, a tax base that is taxed relatively hard will be replaced by a tax base (capital) that generates less tax revenue, and consequently, less tot
Background: Virtual imaging trials (VITs) are in silico studies that simulate medical imaging and disease processes, offering a cost-effective and reproducible addition to traditional imaging trials. While VITs are well established in breast imaging, most existing implementations simulate imaging based on static anatomical models, capturing only a single time point. This limits their ability to st
This chapter will describe how educators can use uncertainty field books to explore students’ experiences as they navigate in complex and uncertain knowledge and information spaces, to engage others, and to start, grow and sustain movements for change using the groaning in the groan zone. In describing the field book, method and practice, but foremost students’ narratives, the chapter sets it up a
Context. The Milky Way nuclear star cluster (MWNSC) is located in the Galactic centre, together with the Milky Way nuclear stellar disc (MWNSD), and they dominate the gravitational potential within the inner 300 pc. However, the formation and evolution of the two systems and their possible connections are still under debate. Aims. We reanalysed the low-resolution KMOS spectra in the MWNSC with the
This study evaluated the adaptation of relapse prevention treatment, originally for substance use, to address problematic gaming in children and adolescents. The goal was to understand the feasibility of this treatment in child and adolescent mental health services from the clinicians’ perspective. Six clinicians, four women and two men aged 37–47 with 4–20 years of work experience, were interview
Multidimensional diffusion MRI is a promising new MRI approach that has the potential to non-invasively give information about brain microstructure at an unprecedented level of detail. The present contribution briefly reviews the salient features of the novel method, its historical background and differences with conventional methods, as well as the remaining challenges that have to be overcome in
Background: Following the results of the MANDARA trial, this real-life study aimed at comparing the effectiveness and safety profile of mepolizumab versus benralizumab in a European EGPA cohort. Methods: We conducted a retrospective observational comparative study including EGPA patients, who received mepolizumab or benralizumab at the asthma dose. Patients were matched 1:1 by sex, age, BVAS and o
Urban climate resilience planning often overlooks the subsurface, despite its potential to mitigate flooding, heat stress, and drought. To demonstrate these potentials, we developed thematic Geosystem Service (GS) maps for Malmö, Sweden, to support the integration of the subsurface into climate adaptation strategies. This study identifies GS relevant to the local context, proposes indicators for m
