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Sex differences in parasite load and immune responses are found across a wide range of animals, with females generally having lower parasite loads and stronger immune responses than males. Intrigued by these general patterns, we investigated if there was any sign of sex-specific selection on an essential component of adaptive immunity that is known to affect fitness, the major histocompatibility c
In this paper we consider a mobile platform with two cameras directed towards the floor mounted the same distance from the ground, assuming planar motion and constant internal parameters. Earlier work related to this specific problem geometry has been carried out for monocular systems, and the main contribution of this paper is the generalization to a binocular system and the recovery of the relat
Objective: Systemic sclerosis (SSc) is a major cause of pulmonary arterial hypertension (PAH). Murine models indicate key roles for chemokines CCL19 and CCL21 and their receptor CCR7 in lung inflammation leading to PAH. The objective of this study was to assess the chemokine CCL19–CCL21 axis in patients with SSc-related PAH. Methods: Serum samples obtained from 2 independent prospective SSc cohort
Preventing the worst consequences of climate change would require that GHG emissions be reduced to levels near zero by the middle of the century. To respond to such a daunting challenge, we need to rethink and redesign the currently highly energy-dependent infrastructures of industrial societies and particularly the urban infrastructures to become low- or even zero-carbon cities. Sustainable urban
The objective was to provide a clinical setup for photoacoustic imaging (PAI) of the temporal artery in humans and to describe the challenges encountered and methods of overcoming them. The temporal artery was examined in 7 patients with suspect giant cell arteritis (GCA), both in vivo and ex vivo, and the results were compared to that of histology. To adapt PAI to human studies, the transducer wa
Kernel based learning algorithms are sensitive to the choice of appropriate kernel function and parameter setting. Classification accuracies yielded by the kernel based classifiers may show variation depending on the choice of the kernel and its associated parameters. Suggesting an efficient kernel function and effective setting of kernel parameters are thus important problems for kernel based cla
The global society has started a journey from using fossil-based raw material to the utilisation of climate-smart sustainable raw materials. Biorefineries have been identified as one of the backbones of the new bioeconomy using fermentation processes to convert biomass to biofuels and –chemicals and thus replacing the conventional C2/C3 chemistry with biotechnological processes. In current petro-c
Lymph node metastasis is the most important prognostic characteristic of colorectal cancer. Carcinoembryonic antigen messenger RNA was shown to detect tumor cells that have disseminated to lymph nodes of colorectal cancer patients and to be at least as good as the hematoxylin and eosin method to predict survival in colorectal cancer patients. CXCL17 was recently shown to be ectopically expressed i
This paper presents work done within the EU project STARR. Within the framework of the project technologies to empower and support stroke survivors are developed. We report on the iterative development of an outdoor activity game for stroke survivors, and discuss design choices, experiences from the initial testing and outline potential future developments.This paper presents work done within the EU project STARR. Within the framework of the project technologies to empower and support stroke survivors are developed. We report on the iterative development of an outdoor activity game for stroke survivors, and discuss design choices, experiences from the initial testing and outline potential future developments.
Semiconductor nanowires can act as nanoscaled optical fibers, enabling them to guide and concentrate light emitted by surface-bound fluorophores, potentially enhancing the sensitivity of optical biosensing. While parameters such as the nanowire geometry and the fluorophore wavelength can be expected to strongly influence this lightguiding effect, no detailed description of their effect on in-coupl
Today, glucagon-like peptide-1 (GLP-1) receptor agonists are established glucose-lowering drugs used in the management of type 2 diabetes. Their development emerged from the understanding that a combined islet dysfunction comprising of impaired insulin secretion and exaggerated glucagon secretion is the key defect of hyperglycemia. GLP-1 was shown to target these defects, and after the discovery t
OBJECTIVES: To simplify the previously published Nottingham 12-year risk prediction model for knee osteoarthritis (OA) and examine whether it can be used to predict the 40-year risk of knee OA in young men.METHODS: We included 40 118 men aged 18 undergoing military conscription in Sweden 1969-70. Diagnostic OA codes were obtained from the Swedish National Patient Register 1987-2010. The original N
Purpose: A hybrid planar-SPECT/CT method for tumor dosimetry in 177Lu-DOTATATE therapy, applicable to datasets consisting of multiple conjugate-view images and one SPECT/CT, is developed and evaluated. Methods: The imaging protocol includes conjugate-view imaging at 1, 24, 96, and 168 h post infusion (p.i.) and a SPECT/CT acquisition 24 h p.i. The dosimetry method uses the planar images to estimat
Most genome sequencing projects using intracellular bacteria face difficulties in obtaining sufficient bacterial DNA free of host contamination. We have developed a simple and rapid protocol to isolate endosymbiont DNA virtually free from fly and mosquito host DNA. We purified DNA from six Wolbachia strains in preparation for genome sequencing using this method, and achieved up to 97% pure Wolbach
The xyn1 encoded 5 domain xylanase from the thermophilic bacterium Rhodothermus marinus binds specifically to xylan, β-glucan and amorphous but not crystalline cellulose. Our results show that the binding is mediated by the full length xylanase, but not by the catalytic domain only. Based on similarities concerning both predicted secondary structure and binding specificity found with one cellulose
Partially premixed combustion (PPC) in internal combustion engine as a low temperature combustion strategy has shown great potential to achieve high thermodynamic efficiency. Methanol due to its unique properties is considered as a preferable PPC engine fuel. The injection timing to achieve methanol PPC conditions should be set very close to TDC, allowing to utilize spray-bowl interaction to furth
The topic of social equity in transport planning has been dealt with in particular by authors such as Martens (2012) and Martens and Golob (2012) using a social justice based approach. However, such an approach, whilst valuable and analytically rigorous (based as it is on accessibility modelling), does not consider a wide range of possible other social impacts of transport, as set out in a framewo
Biodegradable patches made from polyhydroxybutyrate (PHB) were used to close experimentally induced atrial septal defect in six calves. The implants were evaluated after 3-12 months macroscopically and by light and scanning electron microscopy with regard to regeneration of tissue and degradation of the polymer. At implant degradation, complete endothelial layers facing the right and left atrium w
