Filtyp
Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous proble
This paper investigates the possibility of using empirical tool life models to predict tool life in a side milling application in a medium carbon steel, C 45E. To do this, an extensive dataset containing 46 data points with different machining parameters are produced. Four different empirical models: Taylor's equation, Colding's equation and Extended Taylor both using depth of cut and feed as well
Background: Patients with severe asthma may present with characteristics representing overlapping phenotypes, making them eligible for more than one class of biologic. Our aim was to describe the profile of adult patients with severe asthma eligible for both anti-IgE and anti-IL5/5R and to compare the effectiveness of both classes of treatment in real life. Methods: This was a prospective cohort s
This paper describes a longitudinal study involving a woman who developed aphasia as the result of a stroke in 1991. Her language and communication abilities have gradually improved, but the biggest improvements have taken place after she began using a digital camera in 1997. The paper describes both changes that have been objectively measured, such as the number of words in her vocabulary and her
The major seminal vesicle secreted proteins in human semen, semenogelin I and semenogelin II, interact non-covalently and via disulphide bridges to instantly form a coagulum upon ejaculation. The coagulum is liquefied after a few minutes due to the action of a prostatic serine protease, prostate-specific antigen (PSA). In contrast to rat semen, which forms an insoluble plug within minutes of expul
Extended Producer Responsibility (EPR) schemes are adopted not only to promote collection and recycling of waste products but also to close material loops and incentivise ecodesign. These outcomes are also part of creating a more circular economy. Evaluations of best practices can inform how to further optimise systems towards more ambitious collection, recycling and recovery of both hazardous and
The damage caused by the worldwide increase in natural disasters is staggering, with the poor and marginalised slum communities being the most vulnerable. This paper analyses the key variables and their causal relations underlying the complex system of risk and disaster occurrence in slum areas in El Salvador. Slum dwellers’ views and knowledge are the focus of this inquiry. A better understanding
