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Using several melanoma proteomics data sets we created a single analysis platform that enables the discovery, knowledge build, and validation of diagnostic, predictive, and prognostic biomarkers at the protein level. Quantitative mass-spectrometry-based proteomic data was obtained from five independent cohorts, including 489 tissue samples from 394 patients with accompanying clinical metadata. We
Evidence for disease-regulated transgene expression in the brain with use of lentiviral vectors Evidence for Disease-Regulated Transgene Expression in the Brain With Use of Lentiviral Vectors Johan Jakobsson,1 Nina Rosenqvist,1 Karl Mårild,1 Denes v. Agoston,2 and Cecilia Lundberg1* 1Department of Experimental Medical Research, Section for Neuroscience, Wallenberg Neuroscience Centre, Lund Univer
With an increasing population, a growing middle class and increased resource use, our current ways of living and doing business are unsustainable. Next to the implementation of innovative technology, sustainable development based on innovative business models, better understating of customer needs and behavioural change are crucial. This research aims at combining principles from both sustainable
A comparative study of the antioxidant activity of hydroxytyrosol (HT) and phosphatidyl derivatives of hydroxytyrosol (PHT) added at increasing concentrations to diverse edible oils (lard oil, refined olive oil, and diacylglycerol-rich oil) was performed. Antioxidant activity index was estimated as the ratio of induction time in presence of the compounds to induction time in their absence, after o
The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate, was determined. The impact of incorporating two sparingly water soluble model d
This presentation will engage with the issue of educational reform in the Middle East, discussing preliminary findings of a recently initiated research project on community based educational projects in Beirut. Such initiatives will be discussed in relation to national Lebanese educational policies and practices, as well as in relation to international educational programs such as Education for Al
Objective: To compare the appearance and measurement of Cesarean hysterotomy scar before pregnancy and at 11–14 weeks in a subsequent pregnancy. Methods: This was a prospective cohort study of women aged 18–35 years who had one previous Cesarean delivery (CD) at ≥ 37 weeks. Women were examined with saline contrast sonohysterography 6–9 months after CD. A scar defect was defined as large if scar th
Skogar täcker ca 31% av jordens landyta och lagrar stora mängder kol i biomassa och i marken. I klimatavtalet från Paris 2015 lyfts skogars roll som sänkor och reservoarer av kol fram och undertecknande länder uppmanas att implementera strategier för hållbart skogsbruk som ytterligare förstärker skogars roll som sänkor av växthusgaser. Ett aktivt skogsbruk påverkar klimat och miljö på många olika Forest ecosystems cover 31% of the terrestrial land area and store large amounts of carbon in biomass and in soils. The 2015 Paris Agreement recognizes the importance of sinks and reservoirs of greenhouse gases (GHGs) in forests and the importance of enhancing them through sustainable forest management policies. Managing forests for climate mitigation purposes is, however, complex since management
The study of airborne bacteria relies on a sampling strategy that preserves their integrity and in situ physiological state, e.g. viability, cultivability, metabolic activity, and ice-nucleation activity. Because ambient air harbors low concentrations of bacteria, an effective bioaerosol sampler should have a high sampling efficiency and a high airflow. We characterize a high-flow-rate impinger wi
Background: Sport-related concussion (SRC) is a common and complex injury in athletic populations. Linear head acceleration (LHA) and rotational head acceleration (RHA) are key biomechanical factors believed to contribute to SRC, each through distinct mechanisms. Evaluating head impact magnitudes across different sports, athlete populations, and measurement methods is essential for advancing SRC
We have studied the use of complimentary alternative medicine (CAM) among 233 consecutive breast cancer patients operated on at the Lund University Hospital, Sweden between 2002 and 2004. Questionnaires were administered preoperatively (n = 233), and again 3-6 months post-operatively (n = 167) and one year after surgery (n = 88). At baseline, 14,5% used CAM, 3-6 months post-operatively 14,4% used Bruket av naturläkemedel och andra faktorer som kan interagera med behandling av bröstcancer kartläggs i en pågående studie hos bröstcancerpatienter i Lund; i artikeln redovisas basdata för 233 patienter. Vid inskrivningen använde totalt 14,5 procent av patienterna naturläkemedel, vid 1-årskontrollen 18,2 procent. Sammanlagt 35 olika preparat användes, varav soja och övriga fytoöstrogener, vitlök,
Background: The spread of SARS-CoV-2, originating in Wuhan, China, was classified as a pandemic by the World Health Organization on March 11, 2020. The governments of affected countries have implemented various measures to limit the spread of the virus. The starting point of this paper is the different government approaches, in terms of promulgating new legislative regulations to limit the virus d
Children's early engagement in design of outdoor spaces can form the basis of later attitudes and responsible action for sustainability. The present study is part of a participatory action research project in an urban multi-ethnic preschool in Sweden, involving children, parents, preschool staff and management with a focus on improving the preschool playground. The methodology involved children ta
Capsule endoscopy (CE) is indicated as a first-line clinical examination for the detection of small-bowel pathology, and there is an ever-growing drive for it to become a method for the screening of the entire gastrointestinal tract (GI). Although CE's main function is diagnosis, the research for therapeutic capabilities has intensified to make therapeutic capsule endoscopy (TCE) a target within r
Today’s traffic is one of the main concerns of urban managers. One of the solutions that have been proposed to reduce traffic is encourage people to use public transport instead of personal vehicles, so the quality of public transport should be increased. One way promoting public transport systems quality is creating urban traveler guidance system. In other hand, public transportation network is l
District heating and cooling systems offer a cost-effective and secure supply of heating and cooling to connected buildings. They are widely recognised as a key solution to decarbonise the building sector due to their high potential of integrating renewable energy sources. The systems traditionally involved generating heating and cooling centrally with distribution through separate pipes before de
BACKGROUND: Globally, 700 000 people die every year by suicide. Health care consultation patterns the period before suicide could be one potential way to identify people at risk for suicide. Therefore, this study examines health care patterns up to one year prior to the suicide by age, sex and prior diagnoses and specifically investigates if and how this differs from the general population of Skån
Extreme weather events like floods are expected to become more common asclimate change continues, putting health at risk. Systems should be able tocontinue delivering essential health services when shocked by events like floodsand provide care for the expected new health needs caused by the shock.Resilient health systems have the capacity to maintain their functions and tochange when shocked, enab
