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To examine the activity of matrix metalloproteinases (MMPs) and aggrecanase in control and diseased human articular cartilage, metabolic fragments of aggrecan were detected with monospecific antipeptide antibodies. The distribution and quantity of MMP-generated aggrecan G1 fragments terminating in VDIPEN341 were compared with the distribution of aggrecanase-generated G1 fragments terminating in NI
A high diet quality according to the Swedish nutrition recommendations is associated with a reduced risk of cardiovascular disease in the population-based Malmö Diet and Cancer cohort. To further clarify this protective association, we examined the association between high diet quality and change in triglycerides, high density lipoprotein-cholesterol (HDL-C), and low density lipoprotein-cholestero
Risk factors of stroke/thromboembolism (TE) and major bleeding, and incidence of these events in specific age categories in warfarin-treated patients with mechanical heart valves (MHV) are uncertain. Our objective was to calculate event rates in specific age categories and identify risk factors for adverse events. Methods and results We identified 4,810 treatment periods with MHV between January 2
Rubinstein–Taybi syndrome (RSTS) is a developmental disorder characterized by a typical face and distal limbs abnormalities, intellectual disability, and a vast number of other features. Two genes are known to cause RSTS, CREBBP in 60% and EP300 in 8–10% of clinically diagnosed cases. Both paralogs act in chromatin remodeling and encode for transcriptional co-activators interacting with >400 prote
Background: Differences in stroke care and health outcomes between men and women are debated. The objective of this study was to explore the relationship between patients' sex and post-stroke health outcomes and received care in a Swedish setting. Methods: Patients with a registered diagnosis of acute intracerebral hemorrhage (ICH) or ischemic stroke (IS) within regional administrative systems (IC
Myanmar is endowed with abundant Sn-W mineralization, pre-eminent amongst which is the world-class Mawchi deposit. In the Mawchi area, N-S trending vertical or steeply dipping quartz veins are hosted by both Eocene granite and Carboniferous to Early Permian metasediments. Three stages of ore formation are recognized; (i) tourmaline-cassiterite stage (ii) main ore stage and (iii) sulfide stage. Tou
The protein gC1qR (globular C1q receptor), also named p33, was originally identified as a binding partner of the globular heads of C1q in the complement system. gC1qR/p33 is abundantly expressed in many cell types, but the functional importance of this protein is not completely understood. Here, we investigate the impact of gC1qR/p33 on the production and function of the pathophysiologically impor
This is a proposal to organize a session.Description:The rapid development of the technological progress is constantly reshaping the organization of the firm, raising important labour law issues.One of the red treads of this phenomenon is the shifting of the focus from the “activity” performed by the worker, to the “result” obtained.In the past it was not always possible to measure the output prod
Understanding public responses to environmental policies can help in achieving a move towards more renewable energy. Focusing on two types of public responses to a policy, namely public acceptance and public support, this study utilizes a survey of car owners (N = 1422) to explore public responses to an environmental transport policy in Sweden. The results demonstrate higher levels of public accep
C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of
A high-resolution chemostratigraphical (coupled δ13Ccarb and δ18Ocarb) study of the topmost Floian through the middle Darriwilian (Ordovician) succession at the Hällekis quarry, Kinnekulle, southern Sweden, shows relatively steady isotopic values with overall minor changes, although some notable short- and long-term shifts are discernible. A pronounced positive shift in δ13C in the uppermost part
Avian haemosporidians are vector-transmitted blood parasites that are distributed worldwide, abundant in many bird families and well studied across Europe and North America. Since avian haemosporidians have been poorly examined in the Palearctic migratory flyways of the Western Balkans, the goal of this study was to investigate which species of three haemosporidian genera, Plasmodium, Haemoproteus
Klimatomställning ses av många som en väg ut ur den hotande klimatkrisen. Problemet är bara att klimatomställning inte är ett entydigt begrepp, varför det i klimatdebatten förekommer olika uppfattningar om hur genomgripande samhällsförändringar som krävs för att begränsa den globala uppvärmningen. Somliga ser en radikal omställning av de ekonomiska och politiska systemen som en nödvändighet, medan
This study investigates the effects of Age of Onset of Acquisition (AOA) and the quality and quantity of input on the longitudinal development of gender in the acquisition of French by simultaneous (2L1) and successive bilingual children (cL2). There's an on-going debate regarding the main factors underlying linguistic development in bilingual children. Two independent variables, AOA and input, ha
Microscreening (using Discfilters) is a widely used technology for suspended solids removal in tertiary effluent streams of wastewater treatment plants. Several pilot studies have shown the feasibility of using coagulation and flocculation in combination with microscreens for advanced phosphorus removal, but the number of fullscale references is still limited. In summer 2014, the first Scandinavia
Complex formation between Pd(H2O)42+ and Pt(H2O)42+ and the thioethers Me2S, Et2S, 1,4-dithiane, and 1,4-thioxane has been studied as a function of temperature (278-308 K) and pressure (0.1-200 MPa) by use of stopped-flow and conventional spectrophotometry in an aqueous 1.00 M perchloric acid medium. The rate constants k1 for complex formation are similar for the four thioethers, varying only betw
