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PET with F-18-choline (F-18-FCH) is used in the diagnosis of prostate cancer and its recurrences. In this work, biodistribution data from a recent study conducted at Skane University Hospital Malmo were used for the development of a biokinetic and dosimetric model. Methods: The biodistribution of F-18-FCH was followed for 10 patients using PET up to 4 h after administration. Activity concentration
Despite the importance of regioselective reductive openings of cyclic acetals, mechanistic details are scarce. In this study 4,6-O-benzylidene acetals were used as model compounds for deciphering the mechanism of regioselective openings using a variety of reducing agents. Competitive isotopic studies aiming at primary and secondary isotope effects, as well as an electron-deficient substrate, were
Perinatal factors including high birth weight have been associated with childhood brain tumors in case-control studies. However, the specific contributions of gestational age and fetal growth remain unknown, and these issues have never been examined in large cohort studies with follow-up into adulthood. We conducted a national cohort study of 3,571,574 persons born in Sweden in 1973-2008, followed
International water resources agreements for transboundary rivers in southern Africa are generally founded in system analysis models for water planning and allocation. The Water Resources Yield Model (WRYM) developed in South Africa has so far been the only model applied in official joint water resources studies aimed to form water-sharing agreements. The continuous discussion around the model per
Measurements of water content profiles are of great interest in hydrology and soil science. Time domain reflectometry (TDR) is a well-established method for water content measurements; however, most TDR probe designs are suitable for measurements in only a small soil volume. In this article, a 1-m long TDR profiling probe with five measurement sections is described. Unlike most other previous prof
We develop theoretical and computational tools which can appraise traffic flow models and optimize their performance against current time-series traffic data and prevailing conditions. The proposed methodology perturbs the parameter space and undertakes path-wise analysis of the resulting time series. Most importantly the approach is valid even under non-equilibrium conditions and is based on p
In this investigation, a gas chromatography/mass spectrometry (GC/MS)-based metabolomic protocol for adherent cell cultures was developed using statistical design of experiments. Cell disruption, metabolite extraction, and the GC/MS settings were optimized aiming at a gentle, unbiased, sensitive, and high-throughput metabolomic protocol. Due to the heterogeneity of the metabolome and the inherent
Tetraplegic patients have to depend upon someone else for moving the wheelchair or typing on a computer. One of the ways to make them independent is by using tongue-controlled in-mouth wireless devices. This letter presents antennas and propagation for such devices in 2.45 GHz ISM band. A monopole and a loop antenna suitable in size and performance is presented for such devices. The propagation li
The innovation process is a challenge for companies trying to achieve better outcomes through new ideas or products. The related literature discusses the importance of innovation as a learning process, underlined by a design perspective. Supported by design, the innovation process combines multidisciplinary aspects of creativity and dynamism, mainly for end-user oriented industries. For other indu
A highly optimized Monte Carlo (MC) code package for simulating light transport is developed on the latest graphics processing unit (GPU) built for general-purpose computing from NVIDIA - the Fermi GPU. In biomedical optics, the MC method is the gold standard approach for simulating light transport in biological tissue, both due to its accuracy and its flexibility in modelling realistic, heterogen
Summary of key messages for policy makers • Systemic approach is critical Climate change and natural resource depletion continues to be driven not least by unsustainable levels and patterns of consumption. There is growing recognition that the shift required to achieve sustainable consumption and production is a momentous paradigm shift in Western culture. Due to the holistic nature of shifting c
Antibody-based microarrays have emerged as an established proteomic technology allowing multiplexed and sensitive profiling of complex proteomes, in a high-throughput and miniaturized manner. Recently, numerous applicative efforts have been pursued generating disease-associated protein signatures that now could be further explored for improved disease diagnostics, prognostics and classification.
This report is produced within the Urban Transition Øresund (UT) project (2011–2014), and it is part of the subtask Collaborative Methods and Tools for Urban Transitions (UT CoMeT). The goal of the UT project is to promote sustainable growth and advance sustainable urban transformation in the Øresund region by gathering municipalities, universities and businesses in cross-border cooperation. The s
The main objectives with this investigation are firstly to compare important parameters of a capacitive micromachined ultrasonic transducer (cMUT) for air applications with a corresponding piezoelectric ultrasonic transducer. Secondly, to characterise the cMUT's radiation field using light diffraction tomography. The cMUTs consist of a silicon backplate with small pyramid-shaped cavities and a met
Human antibodies generated in vitro may be highly valuable for diagnostic and therapeutic purposes. For a long time most human antibodies produced in vitro have been of the IgM isotype with rather low affinities. In this thesis a method for production of IgG switched antigen-specific human antibodies is presented. This is a two step protocol, in which the first step is a selection procedure of don
Popular Abstract in Swedish Förebyggande av hjärtkärlsjukdom har varit en utmaning för medicinsk forskning under flera decennier. Viktiga frågeställningar om såväl screeningmetodik som risk-faktor intervention söker fortfarande sitt svar och har i sig betydelse för både samhällsmedicin och klinisk verksamhet. Målsättningen för denna studie var att undersöka möjligheten för läkare och sjuksköterskoCardiovascular disease prevention has been a challenge for research for decades. The studies of this thesis were designed to investigate the role of health professionals in everyday clinical work based upon the concept of comprehensive primary care consultation. Routine check-up of blood pressure was the basis for the inclusion in an opportunistic screening for hyperchol-esterolaemia. Additionally
