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In search for remedies and treatments, science has recurred to Mother Nature. This is where galiellalactone was found, a fungal metabolite isolated from Galiella rufa in 1990. Since then chemists and biologists have been studying its properties and found it to be a potential candidate against castration-resistance prostate cancer (CRPC). The development of a new drug requires many studies of the c
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Platelet-derived growth factors (PDGF) constitute a family of four gene products (PDGF-A-D) acting by means of two receptor tyrosine kinases, PDGFR alpha and beta. Three of the ligands (PDGF-A, -B, and -C) bind to PDGFR alpha with high affinity. Knockout of pdgf-a in mice has demonstrated a role for PDGF-A in the recruitment of smooth muscle cells to the alveolar sacs and their further compartment
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The loading of terrestrially derived macroelements, such as dissolved organic carbon (DOC), total nitrogen (N), and total phosphorus (P), to inland and estuarine waters is increasing in the northern hemisphere. Thesemacroelements often limit heterotrophic bacterioplankton metabolism (production and respiration), which in turn influence food web structures, exchange of greenhouse gases between the
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Generally, simplified manual protocols can serve as a cost-effective alternative to sophisticated automation solutions. We have developed, validated and implemented a quick, inexpensive and efficient one-tube direct lysis DNA extraction protocol for the majority of our crime scene samples. The method includes one pipetting step, the addition of a lysis buffer based on Chelex beads, Proteinase K an
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We study opinion evolution in networks of stubborn agents discussing a sequence of issues, modeled through the so called concatenated Friedkin-Johnsen (FJ) model. It is concatenated in the sense that agents’ opinions evolve for each issue, and the final opinion is then taken as a starting point for the next issue. We consider the scenario where agents also take a vote at the end of each issue and
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Urban infrastructure is crucial for livelihoods and economic growth, however, access remains fragmented. Such differential infrastructure provision within cities necessitates intra-urban comparison and a renewed commitment to re-thinking between and within neighborhoods in ways that do not universalize infrastructure geographies. This paper examines how electricity and water infrastructure affect