Filtyp
The 309T>G polymorphism in the promoter region of the MDM2 gene, known as SNP309, has recently been suggested as an unfavorable prognostic marker in chronic lymphocytic leukemia (CLL) although this has been questioned. To investigate this further, we analyzed the MDM2 SNP309 genotypes in 418 CLL patients and correlated the results with established CLL prognostic factors, time to treatment and over
Popular Abstract in Swedish Ofrivilligt urinläckage, urininkontinens, omfattar mer än 50 miljoner människor i världen, varav cirka 500 000 i Sverige. Av dessa beräknas 2/3 vara kvinnor. Ofrivilligt urinläckage är ett medicinskt och socialt handikapp för den drabbade, operation och hjälpmedel förorsakar samhället stora kostnader. Risken för urininkontinens ökar med stigande ålder. I svenska studierAbstract Pelvic floor disorders (PFD) represent a major public health issue worldwide. Aims of this work Study I: to investigate associations between preoperative resting urethral parameters (MUCP, FL and CA) and objective outcome of laparoscopic colposuspension and, if possible, to identify cutoff values useful in clinical practice. Study II: to investigate a group of perimenopausal women reporti
Purpose: This study investigates the association between mean arterial pressure (MAP) and renal function after out-of-hospital cardiac arrest (OHCA). Materials and methods: Post-hoc analysis of 851 comatose OHCA-patients surviving >48 h included in the targeted temperature management (TTM)-trial. Results: Patients were stratified by mean MAP during TTM in the following groups; <70 mmHg (22%), 70–8
Aim: The aim of this study was to evaluate the therapeutic efficacy and safety profile of orally administered low-dose ketamine for procedural pain management in pediatric cancer patients undergoing lumbar puncture (LP) in a resource-limited hospital setting. Methods: Patients between 4 and 15 years of age, with leukemia, undergoing LP were asked to participate. The study was designed as a t
Introduction: Using a sum score based on a three-graded response scale for the activities of daily living staircase has previously been found to increase the statistical power compared to dichotomized responses when assessing longitudinal changes in activities of daily living. We aimed to investigate if the statistical power could be further increased by using a four-graded scale. Methods: We used
Background and objectives Cognitive and physical difficulties are common in survivors of out-of-hospital cardiac arrest (OHCA); both survivors and close family members are also at risk of developing mood disorders. In the UK, dedicated follow-up pathways for OHCA survivors and their family are lacking. A cohort of survivors and family members were surveyed regarding their experience of post-discha
Emotion regulation has been specifically linked to both non-suicidal self-injury (NSSI) and attempted suicide. It is also known that self-harm is disproportionally higher (30–68.4%) in forensic samples than in the general population, yet knowledge about the association between emotion regulation and self-harm in forensic settings is scarce. The purpose of this study was to describe emotion regulat
We have developed a method for simultaneous tomosynthesis and mechanical imaging, called DBTMI. Mechanical imaging measures the stress distribution over the compressed breast surface. Malignant tissue is usually stiffer than benign, which results in higher stress on the compressed breast and enables to distinguish malignant from benign findings. By combining tomosynthesis and mechanical imaging, w
Tumor growth rate estimations can provide useful information about tumor progression and aggressiveness. Understanding the breast cancer progression and aggressiveness could aid with personalized screening/follow-up, treatment options, and prognosis. This paper reports a preliminary estimation of the tumor volume doubling time (TVDT) for cancers detected during the Malmö Breast Tomosynthesis Scree
BACKGROUND: Studies in men of European ancestry suggest prostate-specific antigen (PSA) as a marker of early prostate cancer (PCa) development that may help to risk-stratify men earlier in life.METHODS: We examined PSA levels in men measured up to 10+ years before a PCa diagnosis in association with PCa risk in 2,245 cases and 2,203 controls of African American, Latino, Japanese, Native Hawaiian,
Antibody microarrays are becoming increasingly established in clinical studies. However, the arrays are seldom used in a quantitative approach but rather for detecting up or down regulated proteins. In this study we describe a microarray procedure being standardized by placing the in-house developed porous silicon surfaces into a commercially available 96 well microtiter plate for analyzing the PS
Purpose: Getting an incurable oesophageal or gastric cancer diagnosis is a major stressful life event associated with severe physical, psychosocial and existential challenges. To provide timely and efficient support, based on patients' experiences, the aim of the study was to explore how patients newly diagnosed with incurable oesophageal and gastric cancer manage everyday life. Method: Semi-struc
Background The implementation of immunological biomarkers for radiotherapy (RT) individualization in breast cancer requires consideration of tumor-intrinsic factors. This study aimed to investigate whether the integration of histological grade, tumor-infiltrating lymphocytes (TILs), programmed cell death protein-1 (PD-1), and programmed death ligand-1 (PD-L1) can identify tumors with aggressive ch
The function of the nucleolus is intimately connected to cell proliferation, division and growth. Many cancer cells have enlarged nucleoli, and several nucleolar proteins have been linked to tumorigenesis. In order to find proteins whose expression is altered in the nucleoli of leukemic cells, we carried out two-dimensional difference gel electrophoresis (2-D DIGE) analyses. Prohibitin (PHB) and T
We performed a large nested case-control study within the Finnish and Icelandic maternity cohorts to verify/falsify the association of maternal EBV infection with an increased risk of acute lymphoblastic leukemia (ALL) in the offspring found in previous studies. All hematologic malignancies diagnosed among children born during 1983 to 2006 in Finland and 1997 to 2005 in Iceland were identified thr
Forest Canopy Height (FCH) is one of the key variables for understanding forest structure distribution and growth. Remotely sensed data such as the NASA Ice, Cloud and Land Elevation Satellite-2 (ICESat-2) ATL08 provides accurate FCH measurements; however, its point-based nature limits spatial continuity. This study addresses the challenge by generating a continuous FCH map over the West Usambara
Background:Preparing for the end of life is believed to help mitigate emotional suffering for both patients and their caregivers. However, empirical evidence on the emotional benefits of feeling prepared for death remains limited.Aim:This study uses data from the international iLIVE project to examine how perceived end-of-life preparedness is associated with emotional suffering among patients and
Objectives: To examine powered mobility learning in children with spinal muscular atrophy (SMA) type I, involving families and evaluating goal attainment through the use of small, modified electric toy cars in the children’s natural environments. Design: Single-blind pilot intervention study derived from an originally planned wait-list randomized controlled trial. This report includes only the imm
As part of the implementation of the Comprehensive Refugee Response Framework and the Global Compact on Refugees we are witnessing the promotion of refugee responses aimed at creating an enabling environment for sustainable investments. This marks a paradigmatic shift “from funding to financing” which sees the role of financial markets becoming central to the way in which refugee responses are man
