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Pyrazinamide (PZA) is a potent first-line agent for the treatment of tuberculosis (TB) with activity also against a significant part of drug-resistant Mycobacterium tuberculosis strains. Since PZA is active only at acid pH, testing for susceptibility to PZA is difficult and insufficiently reproducible. The recommended critical concentration for PZA susceptibility (MIC, 100 mg/liter) used in the Ba
Background: The intervention; "Continuum of Care for Frail Older People", was designed to create an integrated continuum of care from the hospital emergency department through the hospital and back to the older person's own home. The aim of this study is to evaluate the effects of the intervention on functional ability in terms of activities of daily living (ADL). Methods: The study is a non-blind
Previous prevalence rates of non-suicidal self-injury(NSSI) in adolescents have varied considerably. In the present cross-sectional study, prevalence rates, characteristics and functions of NSSI were assessed in a large randomized community sample consisting of 3,060 (50.5 % female) Swedish adolescents aged 15–17 years. The suggested criteria for NSSI disorder in the Diagnostic and Statistical Man
A search for new phenomena in events featuring a high energy jet and large missing transverse momentum in proton-proton collisions at root s = 7 TeV is presented using a dataset corresponding to an integrated luminosity of 33 pb(-1) recorded with the ATLAS detector at the Large Hadron Collider. The number of observed events is consistent with the Standard Model prediction. This result is interpret
A detailed sedimentological study was made on six section walls in the Tvärkroken gravel pit, Idre, west-central Sweden. Based on sediment characteristics, three sedimentary units, units 1-3, were identified. The lowest unit, unit 1, was formed by deposition from sediment-loaded underflows into a stagnant basin. A gradual decrease in water depth is indicated in the upper part of this unit. Post-de
This thesis analyzes blood diamonds and the human rights issues surrounding them. The problems they pose and the promises and limitations of the Kimberly Process are covered along with the development and future impact of man-made diamonds on the demand side of the blood diamond problem. There are two main sections--the first covers blood diamonds and the second man-made diamonds. The introduction
Backgrund: Nederman har ett långsiktigt mål att förbättra enheten i Helsingborg. Ett steg i detta är att se om det finns några förbättringar att genomföra i lagerstyrningen i form av lager- och servicenivåer. Detta då de anställda upplever dagens verktyg som ganska trubbiga för det nuvarande produktsortimenetet och att detta kanske kan förbättras genom ytterliggare en dimension på det befintliga sBackground: Nederman has a long term goal of improving their supply unit in Helsingborg. One step of this is to investigate if there are any improvements to be made in the inventory control in terms of stock levels and service level. This since the employees at Nederman believes that the existing methods are too blunt as a tool for the product range and that their methods can be improved by adding
Computational models play an increasingly vital role in scientific research by enabling the numerical simulation of complex processes. Such models are also fundamental in geosciences. For instance, they offer critical insights into the impacts of global change on the Earth system today and in the future. Beyond their value as research tools, models are also software products and should therefore a
From the early 1990s and onwards the use of debt relief as a method of providing development assistance has become increasingly popular, especially since the launch of the HIPC initiative in 1996. This thesis aims to investigate the general theoretical and empirical support of the growth enhancing properties of debt relief with regard to low income countries. Focus is put on evaluating the harmful
Background: Cutaneous melanoma is steadily increasing worldwide. The new AJCC 8th edition was recently launched and introduced several changes in melanoma staging, particularly for stage III. We conducted a population-based registry study with the purpose to evaluate the impact and prognostic accuracy of the new classification in Sweden. Methods: Consecutive patients diagnosed with stage III melan
Background. The Clubfoot Assessment Protocol (CAP) was developed for follow-up of children treated for clubfoot. The objective of this study was to analyze reliability and validity of the six items used in the domain CAPMotion Quality using inexperienced assessors. Findings. Four raters (two paediatric orthopaedic surgeons, two senior physiotherapists) used the CAP scores to analyze, on two differ
Background: Block-sequential regularized expectation maximization (BSREM), commercially Q. Clear (GE Healthcare, Milwaukee, WI, USA), is a reconstruction algorithm that allows for a fully convergent iterative reconstruction leading to higher image contrast compared to conventional reconstruction algorithms, while also limiting noise. The noise penalization factor β controls the trade-off between n
Expression of mRNAs for neuropeptide Y (NPY) and its receptor subtypes Y1 (Y1-R), Y2 (Y2-R) and Y5 (Y5-R) was studied in adult rat brain using in situ hybridization after 40 rapidly recurring seizures induced with 5-min interval by hippocampal kindling stimulations. At 2-4 h post-seizure, NPY mRNA levels were markedly elevated in dentate granule cells, CA1 and CA3 pyramidal layers, amygdala and pi
Cellular localization and tissue levels of BDNF protein were studied using immunocytochemistry and enzyme immunoassay, respectively, in the cortex and striatum at different reperfusion times (0-24 h) after 2 h of unilateral middle cerebral artery occlusion (MCAO) in rats. The distribution of neuronal injury was analyzed in NeuN-, cresyl violet-, and Fluoro-Jade-stained sections. At 2 h postischemi
The paper discusses how families affected by Typhoon Haiyan have been involved in housing reconstruction in the Philippines and the potential for the use of medium-rise buildings. Case study methodology was conducted based on data collected three months after Typhoon Haiyan. Reconstruction projects show different degrees of users involvement such as “reparation of previous makeshift shelter,”“shel
Retinal implant devices are becoming an increasingly realizable way to improve the vision of patients blinded by photoreceptor degeneration. As an electrode material that can improve restored visual acuity, carbon nanotubes (CNTs) excel due to their nanoscale topography, flexibility, surface chemistry, and double-layer capacitance. If vertically aligned carbon nanotubes (VACNTs) are biocompatible
We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE, Biobank Japan and other studies. We report 568 associations, including 286 autosomal, 7 X-chromosomal and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association anal
