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Objective: North Sea Progressive Myoclonus Epilepsy (NS-PME) is a rare genetic disorder characterized by ataxia, myoclonus and seizures with a progressive course. Although the cause of NS-PME is known, namely a homozygous mutation in the GOSR2 gene (c.430 G>T; p. Gly144Trp), sufficient treatment is lacking. Despite combinations of on average 3–5 anti-seizure medications (ASMs), debilitating myoclo
Introduction Critical care is essential in saving lives of those that are critically ill, however, provision of critical care can be costly and heterogeneous across lower-resource settings. This paper describes the protocol for a systematic review of the literature that aims to identify the reported costs and resources available for the provision of critical care and the forms of critical care pro
The purpose of this thesis is to examine the extend of cybersecurity obligations imposed on healthcare providers under EU law. To achieve this, the research questions focus on selected parts of the NIS 2 Directive and the Cybersecurity Act. Particular attention is afforded cybersecurity risk-management measures required under Article 21 of the NIS 2 Directive, as well as the role of certification
Childhood cancer aetiology is poorly understood and is considered to originate in utero and early postnatal life. In this study, we investigated perinatal characteristics as potential risk factors by performing a population-based case-control study, including 1340 cancer cases diagnosed < 19y and born between 1989–2021 in southern Sweden, and 13400 controls matched by sex, year, and municipality o
This thesis analyses how welfare, entitlement and welfare subjects are discursively constructed in the policy process surrounding the proposed qualification requirements for social insurance benefits and financial assistance, as part of the Swedish social benefit reform, ‘bidragsreformen’. Drawing on Norman Fairclough’s three-dimensional model of discourse analysis, the study examines the governme
Climate change is primarily driven by anthropogenic emissions of greenhouse gases. Reducing these emissions globally requires a massive effort at the individual, city, and national scales. Urban areas are hotspots of anthropogenic emissions, given the high density of human-based activities, and clarity on the variations of emissions in these areas will enable effective targeted reduction plans. Ho
Background: Developing new diagnostic imaging methods that provide detailed visualization of the histoanatomy of tissues and organs requires precise histomorphometric evaluation. With a particular focus on bowel, this study aimed to develop and validate a computer program for reliable and efficient assessment of bowel wall histomorphometry. Methods: A MATLAB-based computer program was developed in
Background: Local networks have been recognized for their potential to govern collaborative action toward a low-carbon future in urban areas, yet there is a need to learn more about the strengths and weaknesses of such governance structures. In this paper we assess the Local Roadmap for a Climate Neutral Building & Construction Industry in Malmö 2030 (LFM30) network which was initiated in 2018
Shifting everyday consumption from linear to circular is a key sustainability challenge, and interventions targeting households and consumers are increasingly promoted as a means to support this transition. However, much remains unclear about the theoretical assumptions that underpin such interventions and how these shape their design and outcomes. This article presents a systematic literature rev
AIMS: To examine the relationships of two screening instruments recently developed for assessment of exhaustion disorder (ED) with some other well-known inventories intended to assess ED-related concepts and self-reports of job demands, job control, job support, private life stressors, and personality factors.METHODS: A cross-sectional population sample ( n = 1355) completed: the Karolinska Exhaus
Most bacteria with a rod-shape morphology contain an actin-like cytoskeleton consisting of MreB polymers which form helical spirals underneath the cytoplasmic membrane to direct peptidoglycan synthesis for elongation of the cell wall. In contrast MreB of Streptomyces coelicolor is not required for vegetative growth, but has a role in sporulation. Beside MreB, S. coelicolor encodes two further MreB
Introduction: Meniscal extrusion is thought to be associated with less meniscus coverage of the tibial surface, but the association of radiographic disease stage with quantitative measures of tibial plateau coverage is unknown. We therefore compared quantitative and semi-quantitative measures of meniscus position and morphology in individuals with bilateral painful knees discordant on medial joint
This thesis engages with the role of social movements within development studies by analysing how these movements relate to their context and how LGBTIQ movements contribute to current studies on grassroots’ contribution to development. It analyses how the historical and current context of in Cape Town, South Africa impacts it LGBTIQ movement and its internal dynamics through the multi- institutio
Forests offer vital ecosystem services but face threats from various stressors, including climate change and insect infestations. The European spruce bark beetle (Ips typographus L.) poses significant risks to Norway Spruce (Picea abies). Early detection of bark beetle infestations is crucial for damage control but challenging with traditional methods. This study aims to utilize modern remote sens
In the interaction between two ecologically-associated species, the population structure of one species may affect the population structure of the other. Here, we examine the population structures of the aphid Metopeurum fuscoviride, a specialist on tansy Tanacetum vulgare, and its specialist primary hymenopterous parasitoid Lysiphlebus hirticornis, both of which are characterized by multivoltine
Parkinson´s disease is characterized by a progressive degeneration of the nigral dopaminergic system. Treatment of disease symptoms using L-DOPA frequently induces side effects such as L-DOPA-induced dyskinesia. New therapeutic approaches are aimed at preventing neurodegeneration or restoring the dopaminergic system by fetal dopaminergic transplants. In this thesis work, we evaluated the neuroprot
Methods for facile synthesis of symmetric and unsymmetric functionalized analogues of Tröger's base were developed with use of 2,8-dibromo-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine (2) as the starting material. C(2)-symmetric 2,8-disubstituted analogues of Tröger's base (4a-f) were synthesized via double bromine-lithium exchange of 2 followed by quench with electrophiles. Desymmetrization via
Ion microprobe U-Th-Pb analyses of zircons in variably metamorphosed and veined orthogneisses in the southern part of the parautochthonous Eastern Segment of the Sveconorwegian (1.20-0.90 Ga) orogen, SW Sweden, broadly define two age groups, oscillatory and sector zoned magmatic zircon cores yield 1.70-1.68 Ga while overgrowths, homogeneous crystals, and recrystallized domains in primary zircon yi
