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The Saccharomyces cerevisiae Elongator complex consisting of the six Elp1-Elp6 proteins has been proposed to participate in three distinct cellular processes: transcriptional elongation, polarized exocytosis, and formation of modified wobble uridines in tRNA. Therefore it was important to clarify whether Elongator has three distinct functions or whether it regulates one key process that leads to m
Introduction The population-based Inter99 cohort has contributed extensively to our understanding of effects of a systematic screening and lifestyle intervention, as well as the multifactorial aetiology of type 2 diabetes (T2D) and cardiovascular disease. To understand causes, trajectories and patterns of early and overt cardiometabolic disease manifestations, we will perform a combined clinical d
The first evidence for the Higgs boson decay to a Z boson and a photon is presented, with a statistical significance of 3.4 standard deviations. The result is derived from a combined analysis of the searches performed by the ATLAS and CMS Collaborations with proton-proton collision datasets collected at the CERN Large Hadron Collider (LHC) from 2015 to 2018. These correspond to integrated luminosi
T lymphocyte acute lymphoblastic leukemia (T-ALL) is a heterogeneous disease affecting T cells at multiple stages of their development and is characterized by frequent genomic alterations. The transcription factor LEF1 is inactivated through mutation in a subset of T-ALL cases but elevated LEF1 expression and activating mutations have also been identified in this disease. Here we show, in a murine
Objective: To develop a standardized sonographic evaluation and reporting system for Cesarean scar pregnancy (CSP) in the first trimester, for use by both general gynecology and expert clinics. Methods: A modified Delphi procedure was carried out, in which 28 international experts in obstetric and gynecological ultrasonography were invited to participate. Extensive experience in the use of ultraso
Purpose: This article presents a discussion of how librarians' engagement in certain social movements manifests itself in public libraries, how librarians justify their engagement with specifically the LGBT + movement and the climate movement and what it might entail in terms of legitimacy. Design/methodology/approach: Besides an extensive international literature on libraries and climate/LGBT + i
BACKGROUND: Exercise and education is recommended as first-line treatment by evidence-based, international guidelines for low back pain (LBP). Despite consensus regarding the treatment, there is a gap between guidelines and what is offered to patients. Digital LBP treatments are an emerging way of delivering first-line treatment.OBJECTIVE: The aim of this study is to evaluate outcomes after partic
The present disclosure relates to compositions, constructs and vectors for reprogramming cells into plasmacytoid dendritic cells or interferon type I-producing cells, methods and uses thereof. The present disclosure relates to the development of methods for making plasmacytoid dendritic cells or interferon type I-producing cells that promote antiviral and anti-tumoral immune responses from differe
Transcriptomic and proteomic profiling classify bladder cancers into luminal and basal molecular subtypes, with controversial prognostic and predictive associations. The complexity of published subtyping algorithms is a major impediment to understanding their biology and validating or refuting their clinical use. Here, we optimize and validate compact algorithms based on the Lund taxonomy, which s
Ground penetrating radar (GPR) is a well-established technique used in archaeological prospection and it requires a number of specialized routines for signal and image processing to enhance the data acquired and lead towards a better interpretation of them. Computer-aided techniques have advanced the interpretation of GPR data, dealing with a wide range of operations aiming towards locating, imagi
Ammonia (NH3) is a promising carbon-free energy carrier. Co-firing of ammonia in solid fuel-fired facilities is a feasible solution to reduce carbon dioxide (CO2) emissions. Solid fuels, such as coal and biomass, contain various trace elements, such as alkali metals and sulfur, which are released to the gas phase during combustion. Experimental characterization and modeling are used to study the p
Public transportation (PT) is an essential system for cities to achieve sustainability. However, determination of proper locations for PT stations and finding suitable routes are critical decisions. This paper aims to propose a novel method to determine BRT stations and routes in the cities, using Fuzzy Inference System (FIS) and Binary Integer Programming (BIP). In the proposed method, first, a s
Recent technological advances have facilitated and diversified the options available for the diagnosis of cardiac arrhythmias. Ranging from simple resting or exercise electrocardiograms to more sophisticated and expensive smartphones and implantable cardiac monitors. These tests and devices may be used for varying periods of time depending on symptom frequency. The choice of the most appropriate h
Based on evidence from urban development projects in the city of Malmö, Sweden, I would like to discuss the idea that the success of the neoliberal utopia is based not in a clear break with its predecessor - social democracy – but in the appropriation, reworking and transformation of the social-democratic ideal to suit specific elite interests. The current institutionalisation of neoliberal planni
