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PURPOSE: To analyze the effect of germline mutations in BRCA1 and BRCA2 on mortality in patients with ovarian cancer up to 10 years after diagnosis.EXPERIMENTAL DESIGN: We used unpublished survival time data for 2,242 patients from two case-control studies and extended survival time data for 4,314 patients from previously reported studies. All participants had been screened for deleterious germlin
The ecological debt concept emerged in the early 1990s from within social movements driven by rising environmental awareness, emerging Western consciousness of responsibility for past colonial subjugations, and a general sense of unease during the debt crisis. First developed organically, mainly in locally-scaled, civil contexts, ecological debt has since gained attention in academia and internati
Source-sorted municipal organic waste collected from different dwelling types in five Danish cities and pre-treated at three different plants was sampled and characterized several times during one year to investigate the origin of any differences in composition of the pre-treated waste introduced by city, pre-treatment technology, dwelling type or annual season. The investigated pre-treatment tech
Wastewater treatment plant operators encounter complex operational problems related to the activated sludge process and usually respond to these by applying their own intuition and by taking advantage of what they have learnt from past experiences of similar problems. However, previous process experiences are not easy to integrate in numerical control, and new tools must be developed to enable re-
The distribution of 50 species in the south Swedish provinces of Skane (Scania). Halland, Blekinge, Oland and Smaland has been mapped. Many of the species are endemic to southern Scandinavia and some are local endemics within the investigated area. However, there are also several species with a wider North European distribution. Within the area, the number of species shows a regular decline from t
To increase the overall ethanol yield from softwood, the steam pretreatment stage can be carried out in two steps. The two-step pretreatment process was evaluated from a techno-economic standpoint and compared with the one-step pretreatment process. The production plants considered were designed to utilize spruce as raw material and have a capacity of 200 000 tons/year. The two-step process result
Different functions for the programming of the cross flow in asymmetrical flow field-flow fractionation were studied with the aim to find the flow conditions most suitable for the molar mass distribution analysis of high molecular weight polysaccharides. A mixture of four differently sized pullulans covering the molar mass range 5.8 x 10(3)-1.6 x 106 g mol(-1) were used as a model sample. Two type
This paper reports on a parallel implementation of a general 3D multi-block CFD code. The parallelization is achieved by using three strategies. Firstly, it is done on dual-processor PC-clusters where Windows NT systems are running. A multi-thread programming model is adopted for the multi-block code, where one thread corresponds to a block. Shared-memory is used for the exchange of inner-boundari
Analysis of small-scale movement patterns of animals we may help to understand and predict movement at a larger scale, such as dispersal, which is a key parameter in spatial population dynamics. We have chosen to study the movement of a soil-dwelling Collembola, Protaphorura armata, in an experimental system consisting of a clay surface with or without physical obstacles. A combination of video re
One way to extend the lean-burn limit of a natural gas engine is by addition of hydrogen to the primary fuel. This paper presents measurements made on a one-cylinder, 1.6- liter natural gas engine. Two combustion chambers, one slow and one fast burning, were tested with various amounts of hydrogen (0, 5, 10 and 15%-vol) added to natural gas. Three operating points were investigated for each combus
This study considers astrophysics, stellar and nebular astronomy in Sweden. Emphasis is on the role of scientific technologies and practice, and the emergence of a modern observational astronomy, supplanting classical astronomy as the most vital field of Swedish astronomy. The introduction of photography and spectroscopy is discussed, mainly focused on Nils Dunér. The mechanical nature of the pho
We have designed and synthesized a new series of azapeptides which act as potential inhibitors of cathepsin B and/or cathepsin K. Their structures are based upon the inhibitory sites of natural cysteine protease inhibitors, cystatins. For the synthesized azapeptides, the equilibrium constants for dissociation of inhibitor-enzyme complex, K-i, were determined. Comparison of these values indicated t
Oranic acid anhydrides (OAAs) are important reactive, low-molecular-weight industrial chemicals which induce allergic rhinitis and asthma in exposed subjects. Specific IgE has been demonstrated in a large proportion of OAA-exposed workers. The characteristics of the OAAs make them excellent model compounds for studies of quantitative structure-activity relationships (QSAR) of allergenicity. In the
Polyphosphoinositides, the different phosphorylated variants of the phospholipid phosphatidylinositol (PtdIns), are used in a wide array of intracellular mechanisms in eukaryotic cells. The phosphorylation of PtdIns at carbon D4, catalyzed by phosphatidylinositol 4-kinase, is an important step in the synthesis of several of these molecules. The presence of different isoenzymes of PtdIns 4-kinase i
Popular Abstract in Swedish Mellan 0.3 och 2.1 % av alla barn föds med portvins fläckar (PWS). Till skillnad mot vissa andra kärlmissbildningar försvinner inte PWS utan tvärtom blir många mer blåröda och tjockare med åren. Majoriteten av patienterna upplever sig vara negativt psykosocialt påverkade av sitt PWS i jämförelse med jämnåriga. Dessa negativa upplevelser minskar efter behandlingarna.(Se This thesis covers 12 years of experience in treating patients with congenital capillary malformations, so called port wine stains (PWS). The wide variation in treatment response to laser therapy has developed a profound need for the development of objective devises to measure treatment outcome, so that the maximum effectiveness of therapy can be achieved without unnecessary treatments. The purpos
