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Designing a system for computer aided diagnosis is a complex procedure requiring an understanding of the biology of the disease, insight into hospital workflow and awareness of available technical solutions. This paper aims to show that a valuable system can be designed for diagnosing kidney lesions in children and adolescents from 99m Tc-DMSA scintigraphy images. We present the chain of analysis

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To escape competition at the dung pile, a ball-rolling dung beetle forms a piece of dung into a ball and rolls it away. To ensure an their efficient escape from the dung pile, the beetles rely on a celestial compass to move along a straight paths. Here, we analyzed the reliability of different skylight cues for this compass and found that dung beetles rely not only on the sun, but also on the skyl

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Genome wide association studies (GWAS) identify susceptibility loci for complex traits, but do not identify particular genes of interest. Integration of functional and network information may help in overcoming this limitation and identifying new susceptibility loci. Using GWAS and comorbidity data, we present a network-based approach to predict candidate genes for lipid and lipoprotein traits. We

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We propose a novel Bayesian network tool to model the probabilistic relations between a set of type 2 diabetes risk factors. The tool can be used for probabilistic reasoning and for imputation of missing values among risk factors. The Bayesian network is learnt from a joint training set of three European population studies. Tested on an independent patient set, the network is shown to be competiti

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Understanding, monitoring and mitigating drought is a very difficult task as a consequence of the intrinsic nature of the phenomenon. In addition, assessing the impact of drought on ecosystems and societies is also a complex task, because the same drought severity may have different consequences in different regions and systems due to the underlying vulnerabilities. New technologies based on geosp

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To report contemporary outcomes, and evaluate differences after thrombolysis for occluded endoprosthesis, bypasses and native artery occlusion in patients with lower limb ischemia.

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CONTEXT: Prior research suggests that drug abuse (DA) is strongly influenced by both genetic and familial environmental factors. No large-scale adoption study has previously attempted to verify and integrate these findings. OBJECTIVE: To determine how genetic and environmental factors contribute to the risk for DA. DESIGN: Follow-up in 9 public databases (1961-2009) of adopted children and their

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The partitioning of 10% (w/w) lactic acid in ethylene oxide propylene oxide (EOPO) random copolymers and dextran T500 aqueous two-phase systems was studied. An analysis of variance design was applied to investigate the effect of pH, polymer concentration, and addition of polyethyleneimine to the aqueous two-phase systems. The lowest lactate partition coefficient of 0.09 was obtained at pH 6 in the

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Popular Abstract in Swedish Information om smärta, klåda och temperaturförändringar förmedlas till centrala nervsystemet av tunna nervfibrer som leder nervimpulser relativt långsamt. Information om beröring av huden förmedlas istället av grova och snabbt ledande nervfibrer. Det är välkänt att olika känselkvaliteter kan interagera med varandra på olika nivåer i centrala nervsystemet. Vanlig berörinIt is known that stimulation of thin nerve afferents can inhibit itch and pain and that the nociceptive systems have a detailed topographical organisation, with subsystems exhibiting specific excitatory and inhibitory receptive fields. On this basis, a new technique was developed, termed Cutaneous Field Stimulation (CFS), that electrically stimulates thin nerve fibers innervating specific skin fie

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Popular Abstract in Swedish Strålningsterapi är en viktig metod för att behandla många cancertyper och man söker konstant efter olika sätt att förbättra användningen av joniserande strålning vid behandling. Radiobiologisk forskning för cancerterapi söker att förbättra vår förståelse för hur joniserande strålning verkar på olika livsformer. Idag finns det många sätt att utröna en behandlings inverkFor the development of a Single–Ion Hit Facility (SIHF) for living cells irradiation at the Lund Ion Beam Analysis facility (LIBAF), newly developed pre-cell detectors have been investigated. These detectors can determine the number of ions reaching the sample. Central to the thesis is their fabrication and characterization. Two different detectors ’ Design A and Design B’ were fabricated with thi

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This study uses the Swedish register of prescribed drugs, merged with the Survey of Living Conditions (the ULF), to analyze the socioeconomic gradient in drug utilization. It finds a significant education gradient (but no income gradient) in individual drug utilization. Whereas the education gradient for men is quantitative in its orientation (education affects number of drugs used), the gradient

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In Australia a national public/private telematics framework has been established, which is administered by Transport Certification Australia (TCA). The first application was the Intelligent Access Program (IAP), which has enabled several road transport reforms by managing infrastructure risks associated with the operation of extra heavy vehicle configurations. The paper uses the IAP to demonstrate

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Popular Abstract in Swedish Inflammerat brosk i halsen. Rethosta eller andningsbesvär. Autoimmuna sjukdomar uppstår när immunförsvaret angriper och bryter ner den egna kroppens vävnader. Då kroppen infekteras av bakterier eller virus är immunförsvarets ökade aktivitet däremot en normal skyddsmekanism. Exempel på vanligt förekommande autoimmuna sjukdomar är diabetes, reumatoid artrit (RA) och multRelapsing polychondritis (RP) and rheumatoid arthritis (RA) are autoimmune diseases where an inappropriate immune response destroys cartilage. In RP, the ears, larynx, nose and joints are affected, while the most prominent sign of RA is arthritis. For ethical reasons many experiments can not be performed in man, and consequently animal models are needed. To investigate the complexity of the tissu