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Background: Newborn infants undergoing therapeutic hypothermia (TH) are exposed to multiple painful and stressful procedures. The aim of this systematic review was to assess benefits and harms of pharmacological and non-pharmacological interventions for the management of pain and sedation in newborn infants undergoing TH for hypoxic-ischemic encephalopathy. Methods: We included randomized and obse

In recent years the development and use of crash prediction models for roadway safety analyses have received substantial attention. These models, also known as safety performance functions (SPFs), relate the expected crash frequency of roadway elements (intersections, road segments, on-ramps) to traffic volumes and other geometric and operational characteristics. A commonly practiced approach for

Biobank samples stored in biobanks give researchers and respiratory healthcare institutions access to datasets of analytes valuable for both diagnostic and research practices. The usefulness of these samples in clinical decision-making is highly dependent on their quality and integrity. New procedures that better preserve sample integrity and reduce degradation are being developed to meet the need

The third meeting of the International Society for Holter and Noninvasive Electrocardiology working group was convened in Lund, Sweden, in June 2010 to consider the key clinical challenge of developing electrocardiographic (ECG) criteria for identification of the global subendocardial ischemia that results from subtotal occlusion of either the left main coronary artery or its equivalent. The parti

BACKGROUND: The American Diabetes Association (ADA)/European Association for the Study of Diabetes (EASD)/International Diabetes Federation GDFAFCC Consensus Statement on the worldwide standardization of HbA(1c) states that"...[HbA(1c)] results are to be reported world-wide in IFCC units...and derived NGSP units...,using the IFCC-NGSP master equation." METHODS: We describe statistical methods to e

Background. The procedure of human islet isolation needs further optimization and standardization. Here, we describe techniques to enhance enzymatic digestion and minimize mechanical forces during the digestion process. The isolation protocol has also been modified to meet current GMP (cGMP) standards. Moreover, the impact of donor- and process-related factors was correlated to the use of islets f

Background Up-to-date evidence on levels and trends for age-sex-specifi c all-cause and cause-specifi c mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across

Extended Producer Responsibility (EPR) is a policy principle commonly used to manage plastic packaging waste in which the producer is taking a major role. The current discussions reached a point that discusses the necessity of an international EPR, which could extend the producer’s responsibility outside of its national boundary. However, the discussions are lacking those that involve multiple sta

Intro: This study explores the extent to which exercise therapy lowers depression, anxiety, and drug cravings in patients diagnosed with Substance Use Disorder and chronic smokers who are unable to quit independently. Methods: A literature search was conducted until March 2024; journal credibility was confirmed via h-5 index. In total, nineteen randomized and nonrandomized trials (n = 707) were ac

As the negative environmental impacts of contemporary agriculture become still more evident and widespread, the question of how to feed future generations while preserving the vital stability of the planet’s environment is more urgent than ever. Major institutions are targeting the environmental sustainability of agriculture, internationally as well as in Brazil. Brazil is one of the largest agric

In vitro cultured brain tumour cells are indispensable tools for drug screening and therapeutic development. Serum-free culture conditions tentatively preserve the features of the original tumour, but commonly comprise neurosphere propagation, which is a technically challenging procedure. Here, we define a simple, non-expensive and reproducible serum-free cell culture protocol for establishment an

By a combination of surface-sensitive photoelectron spectroscopy and molecular dynamics simulations, we characterize the surface propensity of the iodide anion in aqueous solutions at acidic, neutral, and basic conditions (pH = 1, 6.8 and 13). In both experiments and simulations, an increased surface concentration of I- is found in non-neutral solutions. We interpret these findings in terms of I-

Syftet med studien var att utvärdera en metod för golfspelare att hjälpa sig själva till bättre prestationer under tävling. Undersökningen gjordes på 76 tävlingsspelare i golf i åldrarna 17-19 år. Hypotesen var att interventionen, skapad med övningen Three Blessings Exercise som inspiration, skulle leda till ett positivt tankemönster, vilket i sin tur skulle förbättra spelarnas tillstånd och/eller

Circular economy has recently become a central part of European policy, bridging the environmental and economic policy domains closer than ever in an attempt to fulfil enhanced environmental ambitions. As economic operators seek to adopt innovative solutions, the issue of how established legal frameworks hamper or facilitate them becomes central. This thesis examines this point in relation to on

The Swedish higher education system experienced a dramatic expansion since the 1960s. In the late 1990s and early 2000s, four higher education institutions obtained university status. As a result, scholars based in these universities enjoyed greater access to research resources. This study aims to utilize the 1999-2005 expansion to estimate the effects of increased access to research funds on scie

Post partum depression är ett omfattande folkhälsoproblem som utlandsfödda mödrar löper ökad risk att drabbas av. Rutinmässig screening av alla nyblivna mödrar för post partum depression har implementerats i många länder för att öka identifikationen, men tidigare forskning indikerar att hälso- och sjukvårdspersonal upplever screening av utlandsfödda mödrar som en svår arbetsuppgift. Det övergripanPostpartum depression is a major public health problem, which immigrant mothers are at particular risk of being affected by. Routine screening is implemented by many countries to increase identification, but research suggests that health care professionals experience screening of immigrant mothers as challenging. The overall aim of this thesis was therefore to develop an evidence-based educational