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Antibody-based proteomics offers distinct advantages in the analysis of complex samples for discovery and validation of biomarkers associated with disease. However, its large-scale implementation requires tools and technologies that allow development of suitable antibody or antibody fragments in a high-throughput manner. To address this we designed and constructed two human synthetic antibody frag
This thesis challenges the treatment of trust income received in a country with no trusts in its legal system in light of freedom of establishment and free movement of capital. Can provisions of a Member State that has decided not to have trusts in its legal system make the transfer of shares or even the establishment of a trust elsewhere less favourable? This question, as the starting point of t
Ever since the end of the second world war, Europe has been lagging behind the United States in rocket development. In particular in the last 10 years, the technological gap and American competitive advantage have grown thanks to SpaceX’s development of reusable launch vehicles. A key enabler for the reusability of booster stages is precise rocket engine control. This thesis addresses the objectiv
Galectins are family of cytosolic proteins that function as both positive and negative modulators of various cell processes. Galectin-3 has an altered expression pattern in pathophysiological processes, such as cancer or chronic inflammation, which makes it an interesting target for pharmaceutical research. The treatment of galectin-3 ill-regulation was shown effective in serious conditions like i
Mexico has experienced the dramatic escalation of crime and violence in an organized form since the 1990s, and have also witnessed the highest number of homicides in the last ten years. It has adversely affected the national security, economic growth and social development with an especially detrimental effect on youth in Mexico. This study examines the direct and indirect impacts of drug trade-re
Bakgrund: Innebandy är en sport med hög skaderisk då spelet involverar snabba sväng- och vridrörelser som påfrestar kroppen. Knäleden är den led som är mest drabbad av idrottsskador. Flera studier visar att kvinnor har en högre risk att drabbas av knäskador än män. Implementering av skadeförebyggande träning har i studier resulterat i en minskad knäskadefrekvens för spelare. Trots att studier visa
Policy on Planning for Children and Youth in urbanization environment. Enriching Urban Cityscape for Children and Youth through Scandinavian (Swedish and Danish) child methodology on the old European planning model. In this model, traffic management has the most potential in planning. For the study Dhanmondi, the site planned during the British Empire, was chosen within the capital city Dhaka, Ban
BACKGROUND: Multiple laboratory tests are used to diagnose and manage patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these tests varies substantially. APPROACH: An expert committee compiled evidence-based recommendations for the use of laboratory testing for patients with diabetes. A new system was developed to grade the overall quality of the evidenc
This study evaluated a technique to allow the long-term monitoring of individual fishes of known sex in the wild using sex confirmation in close proximity to the reproductive period combined with individual tagging. Hundreds of partially migratory roach Rutilus rutilus were tagged with passive integrated transponders (PIT) following sex determination in spring and various performance measures were
Popular Abstract in Swedish Benskörhet (osteoporos) är ett tillstånd som definieras av låg benmassa och ökar med stigande ålder. Osteoporos är idag en av de stora folksjukdomarna och man räknar med att en tiondel av alla män och en fjärdedel av alla kvinnor i Sverige drabbas. Tillståndet är i sig symptomfritt men ökar risken att råka ut för ett benbrott (fraktur) redan vid lättare fall. Frakturer The aim of this thesis was to evaluate risk factors for bone fragility and fractures in postmenopausal women in a long-term perspective. The study period spanned from the age of 48 to age 82 and is thus unique in its length. The studied sample was homogeneous and consisted of 390 north European women from a population-based cohort. At the start of the study, general health and lifestyle parameters
In order to design and investigate the effects of vegetable oil based enzymatically produced liquid crystalline phases (LCPs), oat oil with 15% and 50% polar lipids contents (PL15, PL40) and with different storage conditions were incubated with Lipozyme TL and CalB. PL40 based LCPs were further investigated incorporating 1-10% aspartame (ASP) or ibuprofen (IBU) and all of the LCPs samples were ana
This project involved the testing and establishment of a base combustion procedure for the newly acquired Raddec Gen IV PYROLYSER and focused on the optimization and correction of the laboratory’s previous liquid scintillation counting (LSC) procedure using the Hidex 300 SL. The pyrolyser was verified to be operational and achieve satisfactory and consistent recoveries across the 6 combustion tub
This study uses a novel approach to identifying local contextual conditions conducive, alone or in combination to far-right political violence. The studied case is asylum housing attacks occurring in Sweden 2015-16. Using a fuzzy-set qualitative comparative analysis of eighty-six Swedish municipalities, forty-two of which have experienced arson attacks against refugee housing facilities, we operat
Engaging students in active participation and collaborative learning is an important pedagogical component of teaching and learning in higher education. Teachers use a variety of activities to engage students, such as interactive lectures, presentations, group activities, and projects. A metaphorical understanding of the teaching-learning process may help in the implementation of innovative and gr
We investigated the predictive performance of peripheral quantitative computed tomography (pQCT) measures of both calf muscle density (an established surrogate for muscle adiposity, with higher values indicating lower muscle adiposity and higher muscle quality) and size (cross-sectional area [CSA]) for incident fracture. pQCT (Stratec XCT2000/3000) measurements at the tibia were undertaken in Oste
Blood biomarkers indicative of Alzheimer’s disease (AD) pathology are altered in both preclinical and symptomatic stages of the disease. Distinctive biomarkers may be optimal for the identification of AD pathology or monitoring of disease progression. Blood biomarkers that correlate with changes in cognition and atrophy during the course of the disease could be used in clinical trials to identify
This report proposes a capability assessment framework for countering disinformation, information influence, and foreign interference. At present, much emphasis is placed on the capability to counter disinformation and other associated phenomena. However, few have attempted to systematically define what those countermeasures are, and how they could be placed within a single, coherent capability as
Key topics in the study of host–microbe interactions—such as the prevention of drug resistance and the exploitation of beneficial effects of bacteria—would benefit from concerted efforts with both mechanistic and evolutionary approaches. But due to differences in intellectual traditions, insights gained in one field rarely benefit the other. Here, we develop a conceptual and analytical framework f
Popular Abstract in Swedish Tillväxthormon (GH) insöndras stötvis från hypofysen. Insöndringen är som högst nattetid, och de högsta nivåerna ses under puberteten för att därefter avta succecivt med ökande ålder. En av de vanligaste orsakerna till brist på GH är godartade tumörer i hypofys och hypofysnära områden där även behandling med kirurgi och strålbehandling kan bidra till hypofysinsufficiensIn childhood onset growth hormone deficiency (GHD) a reduction in cardiac left ventricular mass (LVMi) and impairment of cardiac systolic function, as well as in glomerular filtration rate (GFR) has been shown. In study I, we showed that a low dose of GH treatment for 10 months resulted in increased LVMi and kidney size. No significant improvement in cardiac systolic function or GFR, except for a
