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Peptide binding to HLA molecules is a critical step in induction and regulation of T-cell mediated immune responses. Because of combinatorial complexity of immune responses, systematic studies require combination of computational methods and experimentation. Most of available computational predictions are based on discriminating binders from non-binders based on use of suitable prediction threshol
The objective of this study was to assess the use of on-line monitoring to support the QMRA at water treatment plants studied in the EU MicroRisk project. SCADA data were obtained from diary records, grab three Catchment-to-Tap Systems (CTS) along with system descriptions, sample data and deviation reports. Particular attention was paid to estimating hazardous event frequency, duration and magnitu
In this paper we present the implementation of a WebRTC gateway service that can forward ad-hoc RTP data plane traffic from a browser inside a local hospital network to a browser on a local home network. The gateway leverages the same infrastructure used by the hospital to tunnel sensor and control data for medical devices in home-care deployments. In our use case, doctors at hospitals can only ac
he regional coastal evolution model Cascade was enhanced to better describe the transfer and storage of sediment. Focus was on the cross-shore exchange of material from the subaerial to the sub-aqueous portion of the beach and on shoal evolution at coastal inlets. Cross-shore material exchange now includes erosion due to wave impact and overwash, and barrier and dune build-up by wind. Cascade was
Minor structural changes on the surface of proteins can have tremendous impact on their biological properties. When producing therapeutic proteins it is therefore important to verify that the generated protein is the desired one. Small variations such as glycosylations or amino acid substitutions can mean the difference between a functional, defective or even toxic product. This thesis describes
Isoprene is a highly reactive volatile organic compound emitted by vegetation, known to be a precursor of secondary organic aerosols and to enhance tropospheric ozone formation under polluted conditions. Isoprene emissions respond strongly to changes in meteorological parameters such as temperature and solar radiation. In addition, the increasing CO2 concentration has a dual effect, as it causes b
The efficiency of combustion engines is crucial for their future development, prompting researchers to explore various factors to enhance performance. Among these factors, exhaust gases hold significant potential. Typically, exhaust gases carry about 30-40% of the engine's energy, which often remains underutilized. Although technologies like turbochargers have made progress in recovering some
Specific molecular recognition materials are important in analytical applications. It has been a longstanding dream for scientific explorers to realise a versatile method to generate materials that can recognize biological and chemical substance of interests. Toward this goal, developing synthetic polymer materials, molecularly imprinted polymers (MIPs) is one of the most promising approaches. Esp
In this paper we investigate how intrinsic camera calibration and hand-eye calibration can be performed on a robot vision system using the simplest possible motions and a planar calibration object The standard methods on plane-based camera calibration are extended with theory on how to use pure translational motions for the intrinsic calibration and we see how hand-eye calibration can be performed
Understanding the relationship between concepts and experience seems necessary to specifying the content of experience, yet current theories of concepts do not seem up to the job. With Peter Gärdenfors's conceptual spaces theory as a foundation and with enactivist philosophy as inspiration, we present a proposed extension to conceptual spaces theory and use it to outline a model of the emergence o
The generalized Pareto distribution (GPD) is a two-parameter family of distributions which can be used to model exceedances over a threshold. We compare the empirical coverage of some standard bootstrap and likelihood-based confidence intervals for the parameters and upper p-quantiles of the GPD. Simulation results indicate that none of the bootstrap methods give satisfactory intervals for small s
Nanosized soot particles are a serious health hazard in urban air. Upon inhalation they can penetrate deep into the lungs and their fat solubility makes possible their accumulation in other organs such as the brain. For this reason legislation has continuously reduced the allowable emission levels and raised requirements for reporting the status of the exhaust system (OBD, on board diagnostics) in
A research program for the development of a method for computer-aided planning of homes and working environments for disabled people has recently started. The method is being tested at rehabilitation centres in realistic planning situations and has obtained positive response from both the disabled persons and the professionals such as occupational therapists. The requirements and features of the c
