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Popular Abstract in Swedish Affärsklimatet för dagens energimarknad har varit händelserik de senaste två decennierna med introduktaion av den avreglerade elmarknaden och den ökade vikten av miljöfrågor vid design och inköp av energirelaterade anläggningar. Detta har bidragit med krav om nya analyskriterier, vilka inte bara påverkar den tekniska utformningen av komponenter och system, utan även tilThe business climate of the energy market has been eventful over the last two decades, particularly with the introduction of the deregulated electricity market and promotion of environmental issues. This has subsequently lead to new analysis criteria, influencing both technology requirements and production costs. To be able to manage all the questions that have arisen from this the knowledge of th

Popular Abstract in Swedish Tillväxthormon (GH) insöndras stötvis från hypofysen. Insöndringen är som högst nattetid, och de högsta nivåerna ses under puberteten för att därefter avta succecivt med ökande ålder. En av de vanligaste orsakerna till brist på GH är godartade tumörer i hypofys och hypofysnära områden där även behandling med kirurgi och strålbehandling kan bidra till hypofysinsufficiensIn childhood onset growth hormone deficiency (GHD) a reduction in cardiac left ventricular mass (LVMi) and impairment of cardiac systolic function, as well as in glomerular filtration rate (GFR) has been shown. In study I, we showed that a low dose of GH treatment for 10 months resulted in increased LVMi and kidney size. No significant improvement in cardiac systolic function or GFR, except for a

Popular Abstract in Swedish Förekomsten av fetma ökar lavinartat över hela världen, Sverige inte undantaget, och detta är en stor bidragande orsak till att antalet fall av typ 2 diabetes tilltar på ett liknande sätt. Både fetma och typ 2 diabetes är sjukdomar med ett komplicerat mönster av samverkande genetiska och miljömässiga faktorer. Drabbade individer har en klart ökad risk att drabbas av hjäThe worldwide prevalence of obesity and type 2 diabetes is increasing rapidly. Both disorders depend on genetic and environmental factors. The studies included in this thesis investigated the possible association of the FOXC2 and CAPN10 genes with obesity, insulin resistance, type 2 diabetes, and related phenotypes. FOXC2 encodes a forkhead transcription factor, which was identified as a key regul

Background/Aims: Two differently charged polypeptides, poly-L-lysine (PL) and poly-L-glutamate (PG), have previously been shown to reduce postoperative intra-abdominal adhesions. This study aims to investigate the possible toxic effects and to establish a lowest effective antiadhesive dose. Methods: 152 mice were investigated with a well-known adhesion model and given different concentrations of t

An apparatus for static perimetry of the central visual field at 64 points is described. The testing is fully automatic: the test logic is programmed into a mini-computer and the results are plotted as a diagram in polar coordinates. A few cases with small or medium sized visual field defects have been analyzed by conventional methods and by the automatic instrument with satisfying results.

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. The novel associations nearly double the number of genome-wide hits repo

This article presents the methodological requirements for clinical examination and patient-reported outcomes measurements. The assessment of any measurement for clinical research in hand surgery is difficult. A method of measuring a criterion could be 100% reliable but 100% invalid. Bias may be present in our assessment if we do not take into account the methodological requirements related to reli

Four studies developed and validated two dictionaries to capture agentic and communal expressions in natural language. Their development followed the Linguistic Inquiry and Word Count (LIWC) approach (Study 1) and we tested their validity with frequency-based analyses and semantic similarity measures. The newly developed Agency and Communion dictionaries were aligned with LIWC categories related t

Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of over

The recent surge in publications on the history of knowledge may obscure the fact that there are several parallel understandings of what the field is. In this article, I discern five major historiographical directions in contemporary scholarship regarding the history of knowledge. The analytical framework that has so far attracted the most attention is the circulation of knowledge. As productive a

Desalination is an important method for producing drinking water and it has been a freshwater supply alternative for a long time. The water resources in the Gulf Cooperation Council (GCC) countries, are mostly depending on desalination as a major source of (>80 %) drinking water, while the rest comes from groundwater. The largest number of desalination project is located in the Gulf countries (Sau

In economic, scientometric and innovation research, often so-called specialization indices are used. These indices measure comparative strengths or weaknesses as well as specialization profiles of the observation units with respect to certain criteria, such as patenting and publication or trade activities. They allow question like: is Germany specialized in the export of motor vehicles? Or is the

The length of the polymorphic CAG repeat in the N-terminal of the androgen receptor (AR) gene is inversely correlated with the transactivation function of the AR. Some studies have indicated that short CAG repeats are related to higher risk of prostate cancer. We performed a case-control study to investigate relations between CAG repeat length and prostate cancer risk, tumour grade, tumour stage,