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A novel combination of two CD-shaped double-sided silicon strip detectors (DSSD) with Gammasphere, Microball, Neutron Shell, and Fragment Mass Analyzer has been exploited at the Argonne Tandem Linac Accelerator System (ATLAS) facility at the Argonne National Laboratory during an experimental campaign aiming to study proton-unbound states in odd-Z, N
The upstream ends of global supply chains – where raw material extraction or production takes place – are often hotspots for severe sustainability issues such as deforestation, biodiversity loss and human rights violations. Companies are under growing scrutiny from regulators, investors and civil society to ensure upstream-end supply chain sustainability. Yet, companies typically lack visibility b
Popular Abstract in Swedish Utgångspunkten för denna avhandling är de många bekymmer som präglar vår tid - däribland också bekymret om frivillighetens framtid i ett postmodernt samhälle. Det är en paradox, när det å ena sidan hävdas att det moderna samhället är i kris, att den sociala gemenskaperna har brutit samman och att människor inte längre ställer upp, engagerar sig och hjälper varandra. OchThe theme of this thesis is motives for voluntarism - with particular focus on volunteering in social work compared to voluntary work in sports clubs and patient associations. It is based on a combination of different data sources and methodological approaches: surveys, analyses of letters from volunteers and literature studies. Theoretically the thesis is based on two sets of sociological theorie
Advances in liquid chromatography–mass spectrometry have significantly improved proteomic analyses of human plasma. However, information at the level of intact proteoforms remains limited due to the high dynamic range of protein abundance and the complexity of post-translational modifications. To address this challenge, we introduce soluble plasma proteoform analysis via acetonitrile precipitation
Non-technical summary The United Nations' sustainable development goals (SDGs) articulate societal aspirations for people and our planet. Many scientists have criticised the SDGs and some have suggested that a better understanding of the complex interactions between society and the environment should underpin the next global development agenda. We further this discussion through the theory of soci
Background T-cell activation and clonal expansion are essential to effective immunotherapy responses in non-small cell lung cancer (NSCLC). The distribution of T-cell clones may offer insights into immunogenic mechanisms and imply potential prognostic and predictive information. Methods We analyzed α/β T-cell receptor (TCR) clonality using RNA-sequencing of bulk frozen tumor tissue from 182 patien
Butyl 10-undecenoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog methyl undec-10-enoate (CAS # 111-81-9) show that butyl 10-undecenoate is not expected to be genotoxic. Data on butyl 10-undecenoate and read-across analog methyl
The existing information supports the use of this material as described in this safety assessment. Dihydrocarvyl acetate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analogs dihydrocarveol (isomer unspecified) (CAS # 619-01-2) and aceti
The tumor suppressor gene p53 can mediate both apoptosis and cell cycle arrest. In addition, p53 also influences differentiation. To further characterize the differentiation inducing properties of p53, we overexpressed a temperature-inducible p53 mutant (ptsp53Val135) in the erythroleukemia cell line K562. The results show that wild-type p53 and hemin synergistically induce erythroid differentiati
Background: Breathlessness is common in the population and can be related to a range of medical conditions. We aimed to evaluate the burden of breathlessness related to different medical conditions in a middle-aged population. Methods: Cross-sectional analysis of the population-based Swedish CArdioPulmonary bioImage Study of adults aged 50–64 years. Breathlessness (modified Medical Research Counci
