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Background: Randomised clinical trials with a factorial design may assess the effects of multiple interventions in the same population. Factorial trials are carried out under the assumption that the trial interventions have no interactions on outcomes. Here, we present a protocol for a simulation study investigating the consequences of different levels of interactions between the trial interventio
PTSD symptomatology is known to be associated with executive dysfunction. Inhibitory control is a core component of executive functioning, and inhibitory skills are essential both for adequate functioning in everyday life and important in situations following trauma. The aim of the present study was to examine the relationship between trauma exposure, inhibitory control and PTSD symptomatology in
Background: The ongoing Pan-European Real Life (PEARL) phase 4 study is evaluating fremanezumab effectiveness and safety for the prevention of episodic and chronic migraine. This interim analysis reports primary, secondary and exploratory endpoints from when 500 participants completed at least six months of treatment. Methods: Adults with episodic migraine or chronic migraine maintaining daily hea
Adjuvant bacillus Calmette-Guérin (BCG) instillations represent a cornerstone in the treatment of non–muscle-invasive bladder cancer. Instillation schedule and dose modifications have been evaluated in efforts to reduce the incidence of adverse events (AEs), but none so far has the same treatment efficacy as the full-dose recommended schedule. It has been shown that prophylactic quinolone use in c
Background and purpose: Early this century, the high risk strategy of primary stroke and cardiovascular disease (CVD) prevention for individuals shifted away from identifying (and treating, as appropriate) all at-risk individuals towards identifying and treating individuals who exceed arbitrary thresholds of absolute CVD risk. The public health impact of this strategy is uncertain. Methods: In our
Radioactive iodine is commonly used for the treatment of different thyroid conditions since the 1940s. The EANM has developed a standard pre-therapeutic procedure to estimate patient specific thyroid uptake at treatment of benign thyroid diseases. The procedure which models the time dependent fractional thyroid uptake is based on a two-compartment fitting system, one representing the thyroid and t
Quality of life and health utility are important outcomes for patients with Alzheimer's disease (AD) and central for demonstrating the value of new treatments. Estimates in biomarker-confirmed AD populations are missing, potentially delaying payer approval of treatment. We examined whether health utility, assessed with the EuroQoL-5 3-level version (EQ-5D-3L), differed between individuals with a p
Objective In 2015, new FIGO guidelines for CTG interpretation were presented (FIGO-15). In 2017, the previous Swedish guidelines (SWE-09) were replaced with guidelines adapted to FIGOs (SWE-17). The performance of these three templates had not been scientifically evaluated before its clinical implementation. The objective of this study was to compare the sensitivity and specificity to detect fetal
Retinal implant devices are becoming an increasingly realizable way to improve the vision of patients blinded by photoreceptor degeneration. As an electrode material that can improve restored visual acuity, carbon nanotubes (CNTs) excel due to their nanoscale topography, flexibility, surface chemistry, and double-layer capacitance. If vertically aligned carbon nanotubes (VACNTs) are biocompatible
Objective: This study aims to test a Chinese cross-cultural adaptation of the English version of the Person-Centred Care Assessment Tool (P-CAT)and evaluate its psychometric properties. Design: P-CAT was translated/back-translated using established procedures before the psychometric evaluation of the Chinese version was made. Setting: Two hospitals covering urban and suburban areas of Kunming in tOBJECTIVE: This study aims to test a Chinese cross-cultural adaptation of the English version of the Person-Centred Care Assessment Tool (P-CAT) and evaluate its psychometric properties.DESIGN: P-CAT was translated/back-translated using established procedures before the psychometric evaluation of the Chinese version was made.SETTING: Two hospitals covering urban and suburban areas of Kunming in th
Within integration policies in Denmark, something new has happened. Private enterprises have been included in the delivery of a public policy in a Public-Private Partnership that aims at integrating refugees into society. The current issue of the welfare state is to provide public services without increasing the cost for the taxpayers. Public-Private Partnerships can be seen as a solution to this
This paper seeks to investigate the effects of the real exchange rate on the Swedish trade balance. By investigating for the elasticities of demand from the real exchange rate on Swedish exports and imports this paper seeks to present a more detailed and specific estimate than previous studies on the trade balance. An Autoregressive dynamic lag model (ARDL) is used to conduct regressions, using la
This study illuminates civil society organizations (CSOs)’ possibilities to prevent HIV among girls and women in Tanzania, reflecting on policy implications. A qualitative case study was conducted with a purposively selected CSO, Mtandao. Departing from a Socio-Ecological perspective, its staff was interviewed to find out (i) what signifies girls and women vulnerability to HIV infection (ii) how M
I denna kandidatuppsats undersöks den använda retoriken av den Nationella Kampanjen för rätten till laglig, säker och gratis abort i Argentina. Syftet med studien är att under- söka om den reproduktiva styrningen håller på att förändras. Det valda empiriska materialet består av ett dokument som skrivits av den Nationella Kampanjen för rätten till laglig, säker och gratis abort i Argentina. UppsatsThis bachelor thesis investigates the rhetoric used by the National Campaign for the right to legal, safe and free abortion in Argentina. The purpose of the study is to research if the reproductive governance of Argentina is in transition. The empirical material selected consist of a document written by the National Campaign for the right to legal, safe and free abortion in Argentina. The theoreti
Increasing sustainability and combating climate change are one of the key objectives of the European Union’s policies. Adoption of the European Green Deal and commitment to different international treaties and programmes are affecting to various fields of EU law. In competition law, it has been established that the enhancement of environmental objectives must be considered also when assessing hori
This paper explores the relationship between Corporate Social Responsibility (CSR) and the video game industry, taking video game studios as the main subjects. The aim was to understand the perceived importance of implementing CSR initiatives within businesses and to ascertain the current state of the industry in regard to the subject. A review of the literature was conducted in order to comprehen
Today heritage is considered to be an important resource for society and a valuable asset for sustainable development. This notion is true from international to local/regional level. This thesis investigates the current heritage discourse in the European Union (EU) and provides a qualitative assessment of the values and potential impacts of the two case studies, conducted in the proceedings of thi
Climate migration is an emerging topic of research and policymaking in the region of Asia and the Pacific. Migration in the context of climate change is mediated by social, political, and historical factors not solely dependent on the impacts of climate change. Also, migration, including climate migration, is a socially unequal process and has differential impacts on people based on their identity
