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In T lymphocytes, lipid rafts are preferred sites for signal transduction initiation and amplification. Many cell membrane receptors, such as the TCR, coreceptors, and accessory molecules associate within these microdomains upon cell activation. However, it is still unclear in most cases whether these receptors interact with rafts through lipid-based amino acid modifications or whether raft insert
Theory on plasticity driving speciation, as applied to insect–plant interactions (the oscillation hypothesis), predicts more species in clades with higher diversity of host use, all else being equal. Previous support comes mainly from specialized herbivores such as butterflies, and plasticity theory suggests that there may be an upper host range limit where host diversity no longer promotes divers
Objectives. Comparisons between remote magnetic (RMN) and manual catheter navigation for atrial fibrillation (AF) ablation have earlier been reported with controversial results. However, these reports were based on earlier generations of the RMN system. Design. To evaluate the outcomes of the most current RMN system for AF ablation in a larger patient population with longer follow-up time, 112 pat
Background: Non-beta-hemolytic streptococci (NBHS) are a common cause of infective endocarditis (IE). Echocardiography is used to diagnose IE, but it is not known which patients with NBHS bacteremia should undergo echocardiography.Method: Medical records of patients with NBHS bacteremia in southern Sweden from 2012-2014 were studied retrospectively. The patients were divided into two cohorts. In t
The objective of this review is to examine how drug spending in different age groups changed during the 1990s. Time series analysis of registered data on prescription drug spending were performed, along with two decompositions, one of which was spending in three components: price, quantity (defined daily dose) and residual. The size of the residual is a measure of the impact of changes in drug tre
Refugee rights are reserved for the few lucky enough to evade the sophisticated deterrence regime, while the vast majority of the world’s refugees are referred to a life in semi-permanent limbo.
This book analyzes the current trends in the production, dissemination, and use of knowledge which contribute to social inequalities, especially in the Global South. The aim of the text is to explore the possibilities of active involvement by universities in the democratization of knowledge - a process by which people will be able to more easily acquire and utilize knowledge, as well as the result
The treatment of Parkinson's disease (PD) has for over 50 years relied on dopaminergic therapies that are highly effective especially in the early years of the condition, but ultimately are limited by the development of side effects that relate to the nonphysiological stimulation of dopamine receptors including in nonstriatal areas. Targeted regenerative therapies designed to restore specifically
Background: Epigenetic alterations have been recognized as important contributors to the pathogenesis of PDAC. However, the role of histone variants in pancreatic tumor progression is still not completely understood. The aim of this study was to explore the expression and prognostic significance of histone protein variants in PDAC patients. Methods: Liquid chromatography-tandem mass spectrometry (
Purpose: To set forth experiences in the context of the SERGS Pilot Curriculum—the first standardized educational program for robotic use in gynecological surgery—in terms of feasibility, effectiveness and potential for certification. Methods: The Society of European Robotic Gynecological Surgery (SERGS) outlined a Pilot Curriculum for standardized education in robot-assisted laparoscopic gynecolo
The spectral induced polarization (SIP) method is a promising method for many near surface applications, including characterization of contaminated soil. In this study, SIP measurements, high-resolution X-ray tomography and image analysis are combined to investigate clean and tetrachloroethylene (PCE) contaminated sand. This is the first known combination of these methods and the aim of this paper
Recent developments in drilling technology have resulted in about five to ten times faster penetration rates compared to penetration rates of conventional diamond drilling. The increased penetration rates open up for affordable drilling of deep boreholes in regions with cold crust, such as in Scandinavia, allowing for geothermal energy generation in enhanced geothermal systems. We present two infr
The bone material from three archaeological occupation phases at Huseby Klev provides the best source of evidence currently available about the subsistence strategies of pioneer settlers in Northern Europe. The results from Huseby Klev indicate that the pioneer settlers initially relied heavily on marine mammals for their sustenance. This subsistence strategy changed during the second and third oc
The aim of this study is to increase our understanding of the attitudes towards the scientific search for extraterrestrial life among high school and university students in Sweden. The most important results of the analysis are that: (a) the great majority of students believe that extraterrestrial life exists; (b) most students regard searching for extraterrestrial life to be quite important or ve
This article will present and discuss the process of digital co-production and audiences' responses to the full-scale interactive, gestural, visual and musical experience of a Virtual Reality arts play. This was inspired by cist-slab images from the Kivik Grave, which is Sweden's most famous Bronze Age grave. The aim of the VR arts play was to use digital technology to engage users as time-travell
The composition of cultivation media in relation to strain development for industrial application is reviewed. Heterologous protein production and pentose utilization by Saccharomyces cerevisiae are used to illustrate the influence of media composition at different stages of strain construction and strain development. The effects of complex, defined and industrial media are compared. Auxotrophic s
