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Polyamines are organic polycations expressed by all living organisms, which are known to play an essential role in cell proliferation and differentiation. Recent studies revealed their involvement also in cell contractility and migration and in programmed cell death. These processes are known to contribute to restenosis, a pathophysiological process occurring in 10-20% of patients submitted to rev
Objectives. The aims were to develop auditing according to the APO (Audit Project Odense) method for measuring soft data, exemplified by a holistic view, and to test the instrument. Design. A descriptive study of the development of an APO chart and a test registration. Setting. Primary health care, Blekinge County, Sweden. Subjects. Ten general practitioners (GPs) were invited to transform categor
The novel sialyl donor methyl (ethyl 4,7,8,9-tetra-O-acetyl-5-N,N-diacetylamino-3,5-dideoxy-2-thio-3-thiophenyl-D-erythro-beta-L-gluco-non-2-ulopyranosid)onate was used for glycosylation of a lactosyl acceptor to give the GM3-trisaccharide derivative in 83% yield. Introduction of an azido group at C-9" of the GM3-trisaccharide derivative, transformation into a glycosyl acceptor, and sialylation wi
The presence of a specialised dorsal rim area with an ability to detect the e-vector orientation of polarised light is shown for the first time in a nocturnal hymenopteran. The dorsal rim area of the halictid bee Megalopta genalis features a number of characteristic anatomical specialisations including an increased rhabdom diameter and a lack of primary screening pigments. Optically, these special
Several strains belonging to genera Pseudomonas and Achromobacter and characterized by the ability to degrade anionic surfactants were tested as potential bases of microbial biosensors for surfactant detection. For each strain the substrate specificity and stability of sensor signals were studied. The total amount of the substrates tested (including carbohydrates, alcohols, aromatics, organic acid
Analytic expressions for the exact bit error probabilities of rate R = 1/2, memory m = 2 convolutional encoders are derived for a maximum-likelihood (ML) decoder and transmission over the binary-symmetric channel (BSC). The resulting expressions are rational functions of the crossover probability of the BSC. In addition to classical nonsystematic encoders without feedback, we consider also recursi
In a Northern country such as Sweden, energy use in the home may be reduced by 20% through changes in behaviour. However, little is known about how households respond to policy instruments encouraging such change or to what degree this in turn may affect the workload of women and men in such communities. The current study presents findings from interviews with 30 households in Sweden that particip
n instrument suitable for measuring the total water content both as small liquid droplets and as vapour in the air, in water mist total flooding extinguishing tests, is presented. The instrument consists of a heater and a Vaisala humidity meter. The Vaisala humidity meter is capable of measuring relative humidity at temperatures up to 180°C. The instrument has a measuring range of 0-600g/m3, a sam
The thesis concerns the characterization and evaluation of nonsteady heat transfer in building components and building enclosures. The major aim of the underlaying research has been to assemble and develop simplified calculation procedures for this purpose. To establish a simple model for heat balance calculations three main items are treated: simplification of the heat transfer operators, the des
The potential risk for consumers to be exposed to banned azo dyes in leather is strong motivation for the development of an analytical test procedure with improved accuracy. The currently most accepted analytical procedure for this application, the German standard DIN 53316 method, suffers from major drawbacks including low accuracy and the usage of hazardous organic solvents. As a consequence, an
OBJECTIVE—The purpose of this study was to evaluate the metabolic effectiveness, safety, and tolerability of nateglinide in subjects with impaired glucose tolerance (IGT) and to identify a dose appropriate for use in a diabetes prevention study. RESEARCH DESIGN AND METHODS—This multicenter, double-blind, randomized, parallel-group, fixed-dose study of 8 weeks’ duration was performed in a total of
Current internal radiation dosimetry models for the small intestine, and for most walled organs, lack the ability to account for the activity uptake in the intestinal wall. In existing models the cross-dose from nearby loops of the small intestine is not taken into consideration. The aim of this investigation was to develop a general model for calculating the absorbed dose to the radiation-sensiti
In the study of economic-geographic structures, the shifting focus from the national state to the city and its region has highlighted the lack of reliable interurban data sets. The abundance of usable data sets on international structures and ?ows has no counterpart when studying interurban relations, which makes it hard to draw any extensive conclusions regarding the structure of world city netwo
Popular Abstract in Swedish De flesta primärar hjärntumörer utgår ifrån astrocyter, oligodendrocyter och ependymala celler, som är hjärnvävnadens egna celler. Cirka hälften av dessa tumörer ingår i en grupp där tumörtypen heter gliom. Glioblastoma multiforme (GBM) är den mest elakartade tumören inom denna grupp och också den vanligast förekommande.Trots stora forskningssatsningar är behandlingsstrGlioblastoma multiforme (GBM) is the most malignant and also the most common form of brain tumour in humans. The overall aim of this thesis was to investigate morphological and diagnostics features in human GBM that may be of importance for prognosis and treatment. Immunohistochemically stained tissue sections have been microscopically analysed regarding immuno-reactive cells, cell proliferation,
This review summarizes and discusses the use of central health registers in studies of causes of congenital malformations. The review is illustrated using data from the Swedish Medical Birth Register with adjacent registers and gives examples of different methods to identify environmental exposures. The review stresses the usefulness of this approach but also the inherent problems of which the res
