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Melanoma remains the most aggressive form of skin cancer, characterized by high metastatic potential, genetic heterogeneity, and resistance to conventional therapies. The Melanoma MEGA-Study is a multi-center initiative designed to address these clinical challenges by integrating advanced proteogenomic profiling, clinical metadata, with AI-driven digital pathology and machine learning analytics, a

Alternative Economic Models (AEMs) are theoretical frameworks that, if implemented, could fundamentally transform economic systems by aligning financial objectives with sustainability goals. Conducting rigorous research on future-oriented AEMs and other complex sustainability systems presents challenges, particularly due to the exploration of largely unverifiable future possibilities. Qualitative

The article discusses the development and application of the so-called “stigma engagement strategy (SES)” in interviews with stigmatized study populations, drawing on an interview study with Swedish men who have paid for sex. SES is a qualitative methodological approach that utilizes external sources of stigmatizing narratives, such as newspaper articles and columns, as textual probes within inter

For exploring forest performance in the future, dynamic vegetation models are important tools. Tree mortality is a crucial process in these models, but explicit representations of major agents of mortality have often been relatively underdeveloped. In needle-leaved forest in the temperate and boreal zones, bark beetles are often important for the mortality pattern. The European spruce bark beetle

Populations are presumed to be adapted to local environmental conditions via natural selection, with gene flow breaking up local adaptations. In birds, various aspects of feathers may reflect local adaptation. For example, the insulation capacity of feathers could be greater in colder regions, while colour variation may also play a role in adapting to local environmental conditions since darker fe

Northern mires are significant natural sources of atmospheric methane (CH4), yet estimating CH4 emissions remains challenging due to their complex spatio-temporal dynamics. While eddy covariance (EC) measurements provide valuable insights into ecosystem-scale CH4 fluxes (FCH4) over mire areas typically < 0.05 km², the predictability of FCH4 at the mesoscale (∼0.5 – 20 km²) of a mire complex based

The paper deals with the notion of stability for thermo-elastoplastic materials undergoing large strains. The stability analysis is performed by using the perturbation approach applied to a comprehensive material model derived in a thermodynamic format. As the main contribution of this paper a stability condition for a material model incorporating geometrical and material non-linearities under ful

In this article, I identify a key trend for demarcating the “secular” as a Western, Christian achievement. I analyze how the New Testament story often known as “Render unto Caesar” is referenced as a source for the secular West, particularly in writings by European and American conservative thinkers in the 1990s and early 2000s. My argument is that these references to “Render unto Caesar” constitu

In recent decades, a significant advancement in the Global Navigation Satellite System (GNSS) has been adopting the vector tracking (VT) technique, particularly in environments where stable and reliable positioning is essential. It facilitates rapid reacquisition and continuous tracking of GNSS signals by linking the data processing and signal processing modules. In challenging environments affect

Objectives ‒ Chronic pain is a major global public-health issue. In Sweden, 20% adults report moderate to severe chronic pain, with 7% continuously seeking healthcare. Shortcomings in treatment, accessibility, and knowledge in healthcare for chronic pain have previously been reported. A generic treatment structure from primary to specialized care and rehabilitation was missing. This study aims to

Rewetting is widely promoted as a climate mitigation strategy to preserve soil carbon in drained wetlands, although rewetting may enhance methane production and corresponding emissions. The increase in methane emissions following rewetting might be underestimated without considering near-surface methane oxidation under a fluctuating water table. Here, we refined the methane module in Lund-Potsdam-

The operation of instruments and detectors in laboratory or beamline environments presents a complex challenge, requiring stable operation of multiple concurrent devices, often controlled by separate hardware and software solutions. These environments frequently undergo modifications, such as the inclusion of different auxiliary devices depending on the experiment or facility, adding further compl

Nickel-based catalysts are the most promising alternative to replace platinum in hydrogen conversion devices in alkaline media. One approach to narrowing the performance gap between Pt and Ni is to fine-tune the nickel surface coverage by (hydr) oxide (NiOxHy) species, which determines its electrocatalytic activity for the hydrogen oxidation (HOR) and hydrogen evolution (HER) reactions. As Ni easi

Coastal port cities are key regions for carbon emissions (CEs) research in China, due to their industrial density, frequent transportation, and diverse human activities. Taking Ningbo City as a case study, this study employed a top-down accounting method and integrated multiple sources of geospatial data to reveal the spatiotemporal distribution characteristics of CEs from four sectors, including

Global warming accelerates the breakdown of carbon stored in permafrost regions, releasing it into the atmosphere and amplifying climate change, particularly during winter when photosynthesis ceases. The Northern Hemisphere's permafrost is primarily concentrated in two key regions — the Arctic and the Tibetan Plateau — each with distinct environmental characteristics. However, previous studies oft

Effective medical education relies on clearly defined learning objectives that foster deep and meaningful learning. This article presents a consensus-driven proposal for national learning objectives in dermatology and venereology within Sweden’s new medical programme qualifying for licensure. The primary aim is to harmonize educational standards across all medical faculties and to establish a comm