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Europe is struggling to reduce its CO2 emissions and to fulfil commitments made according to Kyoto protocol. At the same time, Europe does not possess enough fossil energy resources to cover its needs and thus consumption of imported fossil fuels is growing, placing threats upon economic stability. In order to combat these challenges, renewable energy sources and biomass in particular are expected
The introduction of new farming technologies, such as high-yielding varieties, has for long been regarded as one of the best strategies to increase agricultural production, and to combat poverty and food-insecurity. Since around 2005, New Rice for Africa (Nerica) is one of the main development strategies for combating such issues in Sierra Leone, and in many other African countries. Africa Rice Ce
Der p 2 is one of the most important allergens from the house dust mite Dermatophagoides pteronyssinus Identification of human IgE Ab binding epitopes can be used for rational design of allergens with reduced IgE reactivity for therapy. Antigenic analysis of Der p 2 was performed by site-directed mutagenesis based on the x-ray crystal structure of the allergen in complex with a Fab from the murine
Watershed projects are one example of a decentralization trend, where the entire community is supposed to be involved in planning and implementation. Watershed projects are often considered a success for the environment treated, and often lead to an increased income for those living in the watershed areas. The specific aim of this thesis is to study the potential gender-specific direct and indirec
Payments for watershed services (PWS) are intended to provide incentives to land users to adopt sustainable land management practices. They are also increasingly viewed as having positive impacts on the livelihood of local communities around protected areas. The St. Paul River, located in the St. Paul River basin, is the main source of potable water and hydroelectricity to Monrovia, a city with ab
Renewable hydrogen can be transported using different hydrogen carriers and modes of transport. Each carrier and mode is associated with different drawbacks and benefits relating to – among other factors – storage density and losses. The forthcoming expansion of offshore wind is likely to be coupled with hydrogen production in some way and there are many different ways that this can be done. Th
Evaluation of Standards and Techniques for Retrieval of Geospatial Raster Data - A study for ICOS Carbon Portal Geospatial raster data represent the world as a surface with its geographic information which varies continuously. These data can be grid-based data like Digital Terrain Elevation Data (DTED) and geographic image data like multispectral images. The Integrated Carbon Observation System (I
Den additiva tillverkningsprocessen och kvalificeringen av komponenter i metall är komplex och tillverkningsmetoden är inte ännu fullständigt förstådd. Syftet med detta examensarbete är därför att förvärva kunskap om kvalificeringsprocesser kopplade till additiv tillverkning i metall och att utveckla en hållbar kvalificering för additivt tillverkade komponenter hos Alfa Laval. KvalificeringsprocedThe process of additive manufacturing and qualification of components in metal is complex, and the manufacturing method is still not fully understood. Therefore, the purpose of this thesis is to gather knowledge of the qualification procedures connected to additive manufacturing in metal and to develop sustainable qualification for additively manufactured parts at Alfa Laval. The qualification pro
Peritoneal dialysis (PD) uses the peritoneal membrane for dialysis. The peritoneal membrane is a thin layer of tissue that lines the abdomen. The lining is used as a filter to help remove extra fluid and poisonous waste from the blood. Everybody is unique. What is normal for one person’s membrane may be very different from another person’s. The kidney care team wants to provide each person with th
The core cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers amyloid beta (Aβ42 and Aβ40), total tau, and phosphorylated tau, have been extensively clinically validated, with very high diagnostic performance for AD, including the early phases of the disease. However, between-center differences in pre-analytical procedures may contribute to variability in measurements across laboratories.
It is well recognised that adolescents and young adults (AYA) with cancer have inequitable access to oncology services that provide expert cancer care and consider their unique needs. Subsequently, survival gains in this patient population have improved only modestly compared with older adults and children with cancer. In 2015, the European Society for Medical Oncology (ESMO) and the European Soci
Chronic liver disease (CLD) is frequently seen in the hemophilia population. The ADVANCE Working Group conducted a cross-sectional study in which people with hemophilia (PWH) aged ≥40 years were included. This study aimed to assess the associations between CLD and its risk factors using data from the H3 study, and to suggest implications for optimal care.Data from 13 European countries were collec
Huntington's disease (HD) is a neurodegenerative disorder caused by an unstable CAG repeat. For patients at risk, participating in predictive testing and learning of having CAG expansion, a major unanswered question shifts from "Will I get HD?" to "When will it manifest?" Using the largest cohort of HD patients analyzed to date (2913 individuals from 40 centers worldwide), we developed a parametri
Stimulation of endogenous kinin receptors promotes growth of androgen-independent prostate cancer PC3 cells via activation of the mitogenic extracellular-signal-regulated kinase (ERK) pathway. In the present study, we show that kinin-mediated mitogenic signalling and prostate-cell growth involves two subtypes of bradykinin (BK) receptors, B1R and B2R. Specific stimulation of either B1R or B2R by t
Basic fibroblast growth factor (FGF-2) is involved in the development and maintenance of the nervous system. Exogenous administration of FGF-2 increased dopaminergic (DA) graft survival in different animal models of Parkinson's disease. To study the physiological function of the endogenous FGF-2 system, we analyzed the nigrostriatal system of mice lacking FGF-2, mice overexpressing FGF-2, and FGF-
The MAKEDEP model is designed to produce the time series of atmospheric deposition and nutrient uptake and cycling needed by dynamic soil chemistry models such as SAFE. A range of new features were implemented in the MAKEDEP model including separate treatment of several tree compartments (e.g. root, stem, bark, branch, canopy) and variable nutrient content in the different compartments. The mo
Background Mental health interventions should demonstrate an effect on patients' functioning as well as his/her needs, in particular on unmet needs whose assessment depends on the perspective of either the patient or the clinician. However, individual met and unmet needs appear to change over time, qualitatively and quantitatively, raising questions about their sensitivity to change and about the
Conservation programmes for endangered, long-lived and migratory species often have to target multiple life stages. The bottlenecks associated with the survival of juvenile anguillid eels migrating into inland waters, the survival and growth of the freshwater life stage, as well as the recruitment and survival of silver eels, migrating back to the ocean to spawn, must be resolved. In this study, w
Aims: This analysis aimed to evaluate the incidence and predictors of the need for permanent pacemaker (PPM) implantation following implantation of the repositionable and fully retrievable LOTUS Aortic Valve Replacement System. Methods and results: The prospective, single-arm, multicentre REPRISE II study with extended cohort enrolled 250 symptomatic, high surgical risk patients with severe aortic
