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Background & objectives: Endoscopy is the current gold standard for evaluation of disease activity in ulcerative colitis. The Mayo Endoscopic Subscore (MES) is commonly used for quantifying disease activity, but it has several weaknesses. Numerous new endoscopic indices have been developed but none of these have been widely implemented, likely due to limited feasibility. The primary objective
Scholarship in peace and conflict studies is paying increasing attention to the role of the environment for conflict transformation and peacebuilding. However, a closer analysis on how different understandings of “nature” implicate policy proposals and approaches to peacebuilding is lacking. In this study, we provide a critical reflection on the diverse understandings and valuations of nature at t
To investigate whether coronary artery disease (CAD) burden is associated with plasma levels of the myocardial biomarkers Troponin I (TropI) and NT-proBNP in a large population-based sample using a cross-sectional design. Coronary computerized tomography (CT) angiography was performed in 25,859 subjects without a history of atherosclerotic disease from SCAPIS study (age 50-65, 52% women). TropI an
This theoretical paper adopts a procedural perspective to identify the challenges associated with the implementation of the full scope of approaches to circular public procurement (CPP). We contend that beyond considering CPP from a substantive standpoint (i.e. the procurement affects outside of the organization), adopting a procedural perspective (i.e. the procurement affects inside an organizati
Introduction: Rimegepant is an oral small-molecule calcitonin gene-related peptide receptor antagonist approved in several countries for acute treatment of migraine and preventive treatment of episodic migraine in adults. This review summarizes the evidence, published to date, for the use of rimegepant as an acute or preventive treatment of migraine. Areas covered: A brief overview of migraine, th
Recently, the incentive structure facing doctoral students and researchers in economics has changed significantly in many European countries as a result of the adoption of the US approach to evaluating research output. This poses a threat to the development and position of the subject of economics in Europe since evaluation for promotion is characterised by an excessive focus on publishing in the
Considering the Islamic perspective on forced migration and displacement, along with the conceptual framework of Islamic social welfare instruments as tools for wealth redistribution to support those in need, this study explores the potential complementarity between Islamic and conventional financing in addressing refugees' basic needs and economic empowerment. Specifically, this research examines
The search for drugs that modulate NMDA receptors has been very active in the latest decades since they play a pivotal role in neuronal death and in several neurological conditions, including stroke, traumatic brain injury, and neurodegenerative diseases. Activating the receptor evokes an entry of calcium into the neuron, thus leading to a rapid depolarization that can be measured using electrophy
BACKGROUND: The diagnostic role of signal-averaged ECG (SAECG) in arrhythmogenic right ventricular cardiomyopathy (ARVC) has lately been questioned. We assessed the value of SAECG-derived late ventricular potentials (LP) in ARVC diagnosis and its association with disease manifestations.METHODS AND RESULTS: Patients with definite ARVC diagnosis or genotype-positive family members who underwent SAEC
Background: The aim was to develop a theoretical framework for how errors in estimated activities propagate to a dispersion in time-integrated activity in radionuclide-therapy dosimetry and how this affects the comparison of radionuclide-therapy dosimetry schemes. Methods: Formulae for the variance of relative errors of estimated time-integrated activities and relative differences in time-integrat
In clinical trials, surrogate endpoints, that are more cost-effective, occur earlier, or are more frequently measured, are sometimes used to replace costly, late, or rare true endpoints. Regulatory authorities typically require thorough evaluation and validation to accept these surrogate endpoints as reliable substitutes. To this end, the meta-analytic framework is considered a very viable approac
Aphids cause massive agricultural losses through direct damage or as pathogen vectors. Control often relies on insecticides, which are expensive and not selective. An interesting alternative is to use aphid sex pheromones nepetalactone (NON) and nepetalactol (NOL) to interfere with aphid mating or attract aphid predators. Here, we explore production of these compounds in plants, as their precursor
Developing an efficient code for large, multiscale astrophysical simulations is crucial in preparing for the upcoming era of exascale computing. RAMSES is an astrophysical simulation code that employs parallel processing based on the message-passing interface (MPI). However, it has limitations in computational and memory efficiency when using a large number of CPU cores. The problem stems from ine
The AU Microscopii planetary system is only 24 Myr old, and its geometry may provide clues about the early dynamical history of planetary systems. Here, we present the first measurement of the Rossiter–McLaughlin effect for the warm sub-Neptune AU Mic c, using two transits observed simultaneously with the European Southern Observatory’s (ESO’s) Very Large Telescope (VLT)/Echelle SPectrograph for R
The modelling of filtered chemical source terms remains a fundamental challenges for large eddy simulation (LES) of reacting flows, such as combustion. This study investigates various scale similarity models for predicting filtered reaction rates. The theoretical foundation of scale similarity models is reviewed, and several extensions and generalisations are proposed. These include the distinctio
This article analyses how a newly established set of actors – online brokerage firms (OBFs) – sought to popularise stock trading among the Swedish populace in the late 1990s. During this period, internet usage took off and stock markets surged rapidly up until the dotcom bubble burst in 2000. Sweden was at the forefront of both these international developments, and we analyse the intimate connecti
