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We propose simple estimation of the location parameter for a density that is unbounded at the mode. The estimator maximizes a modified likelihood in which the singular term in the full likelihood is left out, whenever the parameter value approaches a neighborhood of the singularity location. The consistency and super-efficiency of this maximum leave-one-out likelihood estimator is shown through a

Many children with adverse reactions to beta-lactams are labelled as allergic without performing an allergy study to confirm it. In this retrospective study of 10 years, we have detected only 3.3% positive cases. Although International Guidelines recommend a second allergy work-up in patients with a negative study, we found from our results a low profitability of retesting.

Background: Overdiagnosis and subsequent overtreatment are important side effects of screening for, and early detection of, prostate cancer (PCa). Active surveillance (AS) is of growing interest as an alternative to radical treatment of low-risk PCa. Objective: To update our experience in the largest worldwide prospective AS cohort. Design, setting, and participants: Eligible patients had clinical

The size of the anisotropic domains in a lyotropic liquid crystal is estimated using a new protocol for diffusion NMR. Echo attenuation decays are recorded for different durations of the displacement-encoding gradient pulses, while keeping the effective diffusion time and the range of the wave vectors constant. Deviations between the sets of data appear if there are non-Gaussian diffusion processe

In this paper I discuss how a virtue ethic for the preservation of biodiversity may look like. The starting-point is the virtue ethic proposed by Celia Deane-Drummond. She suggests that the four cardinal virtues of prudence, justice, fortitude and temperance should form the basis of an ethic of nature. Of this four, prudence is the most fundamental. Moreover, Deane-Drummond states that the intelle

Popular Abstract in Swedish Diabetes är en folksjukdom och dess förekomst ökar dramatiskt över hela världen. Typ 2 diabetes, eller åldersdiabetes, är den i särklass vanligaste varianten av diabetes. Typ 2 diabetes är starkt förknippat med övervikt och fetma vilket illustreras av att ca 90 % av alla typ 2 diabetiker är överviktiga. Typ 2 diabetes kan förhindras genom livsstilsförändringar. Många mäThere is currently a dramatic and global increase in obesity, type 2 diabetes (T2D) and associated metabolic disorders. T2D can be delayed or prevented in individuals at risk and identifying and developing new food concepts for the prevention of obesity and T2D is of utmost importance. This thesis describes our work on exploring new food concepts for the prevention of T2D. We have used 3T3-L1 adip

A tool has been developed which can be used to evaluate human gait in a more detailed manner. Its purpose is to record data from an individual during gait then categorize and analyze the intrinsic phases with neuro-fuzzy techni(TRUNCATED)

Yeast strains from more than 31 different genera were screened for the enantioselective reduction of bicyclo[2.2.2]-octane-2,6-dione (1). Reducing activity was found in 80% of the screened yeasts. Bicyclo[2.2.2]octane-2,6-dione was enantioselectively reduced (> 98% ee) to (1R, 4S, 6S)-6-hydroxybicyclo[2.2.2]octane-2-one (-)-2 by 69% of the strains. Enantioselective reduction of the diketone to (1S

Graphic correlation using graptolites and conodonts provides a high-resolution timescale for correlating from coastal to deep oceanic sections and, thereby, also a detailed record of the sequence of changes during the Mulde Secundo-Secundo Event. That interval includes sedimentary facies otherwise unknown in older Wenlock to early Ludlow strata on Gotland. The identified sequence of changes includ

Lightweight floors are often troubled by poor impact-sound insulation. In order to develop and explain structures with acceptable insulation, a deterministic prediction model was developed. The paper considers transmission through the system and the response of the model. Excitation (as caused by the ISO-tapping machine) is considered in a separate paper [1]. The system description employs a spati

Pure Sb0.9V0.9O4 and various preparations with excess of either vanadia or antimony oxide, including mechanical mixtures, have been investigated for propane ammoxidation to acrylonitrile. The catalysts were characterized before and after use in catalysis by various methods, including electron microscopy, infrared spectroscopy and XPS. The catalytic data show that preparations with approximate to S

The asymptotic distribution of the maximum Mn=max1= 0 as t -> ~ or if Σr2t<~, then the limiting distribution is the same as for a sequence of independent normal variables. Here it is shown that this also follows from a weaker condition, which only puts a restriction

A new predictive formula for the total longshore sediment transport (LST) rate was developed from principles of sediment transport physics assuming that breaking waves mobilize the sediment, which is subsequently moved by a mean current. Six high-quality data sets on hydrodynamics and sediment transport collected during both field and laboratory conditions were employed to evaluate the predictive

We have investigated the role of lipid metabolism with regard to beta-cell function and insulin secretion. Lipids are known to play a crucial functional role in the pancreatic beta-cell, where they are essential for adequate hormone release, but may also exert a long-term toxic effect, leading to beta-cell dysfunction. Our studies in mice, where insulin resistance and glucose intolerance was induc

In a search for β-delayed charged particles from 14Be we have obtained an upper limit on β-delayed greek small letter alpha particles, B(βgreek small letter alpha)<1.2×10−4, and found evidence for β-delayed tritons at intensity of 6×10−5

This report describes the design and implementation of {TinyRealTime}, an event-based real-time kernel for the Atmel AVR ATmega8L 8-bit micro-controller. The kernel is event-based and supports fully preemptive earliest-deadline-first scheduling of tasks. Semaphores are provided to support task synchronization. The focus of the report is on the memory management, timing, and internal workings of th

In this chapter, we focus on one element of the fragmentation of global climate governance, namely the overlap between the UN climate regime and the World Trade Organization (WTO). With a view to the appraisal question for the ‘architecture’ theme of this volume, we hold that this overlap not only implies benefits, but may also entail significant drawbacks for the development and implementation of