Filtyp
Allergic contact dermatitis (ACD) develops upon exposure to certain chemical compounds termed skin sensitizers. To reduce the occurrence of skin sensitizers, chemicals are regularly screened for their capacity to induce sensitization. The recently developed Genomic Allergen Rapid Detection (GARD) assay is an in vitro alternative to animal testing for identification of skin sensitizers, classifying
Abstract For activity quantification based on planar scintillation camera measurements, photon attenuation is an important factor that needs to be corrected for in a patient- and organ-specific manner. One possibility for obtaining attenuation correction maps is to use X-ray CT scout images. Since the intensity of scout images is in relative numbers, their image values need to be multiplied by a f
In the light of technological changes, changes in business contexts, decreased number of IS students, changes in educational systems, etc., IS education commentators have urged the IS community to develop new and alternative IS curricula. In response to this, we present a model curriculum for a Bachelor of Science program in business information systems design (BISD 2007). The curriculum has a str
The aim of this work was to investigate the effect of storage in fat-free cheese on physical properties, microstructure and primary proteolysis up to 28 days of storage
Popular Abstract in Swedish För många cancerpatienter är strålbehandling ett viktigt behandlingsalternativ. En framgångsrik behandling kräver att den absorberade dosen till patienten kan ges med stor noggrannhet. Detta eftersom en liten avvikelse i absorberad dos kan påverka behandlingens resultat. Strålbehandling sker idag med avancerad teknik och utrustning där osäkerheterna i varje led i behandThis thesis presents a new verification concept, the virtual accelerator, for dose calculation algorithms used in treatment planning systems (TPSs) for external beam radiotherapy. The algorithm input data required to implement a treatment unit in the TPS are generated by Monte Carlo simulations as are the beam reference data needed for the subsequent evaluation of the dose calculation algorithm. T
Popular Abstract in Swedish Extracellulär matrix är namnet på det molekylära nätverk vilket finns mellan celler i flercelliga organismer. Det består av socker och proteiner organiserade i olika vävnadsspecifika nätverk. Två huvudformer finns, basalmembran och interstitiell extracellulär matrix. Basalmembran ligger som en tunn filt under epitel- och endotelceller, runt fettväv, muskler och periferaBasement membranes are sheet like structures underlying epithelial, endothelial, adipocytes, muscle and peripheral nerve cells. Laminins are an important family of basement membrane proteins implicated in various biological functions through their interactions with cell surface receptors. Laminins are trimers composed of a, b and g chains. Integrins, dystroglycan and other transmembrane glycoprote
As climate models can be used to reproduce historical climates, the outcomes can be used to put climate extremes in to a proper historical perspective. This also allows investigation of nonlinear properties of hydrologic processes (e. g. precipitation, runoff) to better understand regional hydrologic dynamics. To this end, the present study uses results from a so-called 'paleosimulation' (i.e. sim
The single-module non-ribosomal peptide synthetase BpsA from Streptomyces lavendulae has the unique ability to autonomously synthesize a coloured product (indigoidine) from a single substrate (l-glutamine), conditional upon activation by a 4'-phosphopantetheinyl transferase (PPTase) partner. We show that bpsA can be expressed in an entD PPTase gene deleted mutant of Escherichia coli to yield a sen
Background. Peer deviance (PD) is associated with risk for drug abuse (DA). Is this association causal? Method. DA was recorded in official records. PD was defined as the percentage of peers residing in small communities with future DA registrations. We examined offspring in families whose community PD changed when the offspring was 0-15 years of age and then examined families where cousins or sib
Type 2 diabetes is associated with a higher cardiovascular risk and there has been a growing interest in using dietary intervention to improve lipid profile and glucose control. The present work aims at analysing the effects of the enrichment of a normal diet with beta-glucan (3-5 g/d) in free-living type 2 diabetic subjects for 2 months, using a palatable soup. This trial was a parallel, placebo-
In breast tomosynthesis1 (BT) a number of 2D projection images are acquired from different angles along a limited arc. The imaged breast volume is reconstructed from the projection images, providing 3D information. The purpose of the study was to investigate and optimize different reconstruction methods for BT in terms of image quality using human observers viewing clinical cases. Sixty-six cases
During the last 10 years, whole genomes have been sequenced from an increasing number of organisms. However, there is still no data on complete genomes of avian and lizard Plasmodium spp. or other haemosporidian parasites. In contrast to mammals, bird and reptile red blood cells have nuclei and thus blood of these vertebrates contains high amount of host DNA; that complicates preparation of purifi
OBJECTIVE: To evaluate the construct validity of a new rating scale for self-reported impairments in persons with late effects of polio. DESIGN: Psychometric analysis of data on self-perceived impairments in persons with prior polio. PARTICIPANTS: Two hundred and seventy-three persons with prior polio (119 men and 154 women; mean age, 63.5 years). METHOD: Rasch analysis of a 13-item rating scale w
The current regulations governing production of biofuels in the European Union require that they have to mitigate climate change, by producing > 35% less greenhouse gases (GHG) than fossil fuels. There is a risk that this may not be achievable, since land use for crop production inevitably emits the potent GHG nitrous oxide (N2O), due to nitrogen fertilisation and cycling in the environment. We an
Methacrylic acid was produced in high yield by an integrated process involving bioconversion of 2-methyl-1,3-propanediol (2M1,3PD) to 3-hydroxy-2-methylpropionic acid (3H2MPA) via 3-hydroxy-2-methylpropanal (3H2MPAL), and catalytic dehydration of the resulting acid. Whole cells of Gluconobacter oxydans grown on glycerol-based culture medium were used as the catalyst for oxidative biotransformation
