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Background and objective: The treatment landscape of metastatic prostate cancer (mPCa) has evolved significantly over the past two decades. Despite this, the optimal therapy for patients with mPCa has not been determined. This systematic review identifies available predictive models that assess mPCa patients’ response to treatment. Methods: We critically reviewed MEDLINE and CENTRAL in December 20
Background: Young adults with autism often have problems with body awareness, also acknowledged by physiotherapists. This may interfere with various physiological and psychological responses, expressed in reduced movement quality. Basic Body Awareness Therapy (BBAT) may be suitable to address these difficulties, to enhance body awareness and movement quality to manage everyday life. Body Awareness
The European Environmental Research Infrastructures (ENVRI) community, in its pursuit of enabling seamless and FAIR (Findable, Accessible, Interoperable, and Reusable) access to environmental research data and services, has realised the ENVRI Catalogue of Services. This paper provides an in-depth look into the creation of this tool, highlighting the process, the challenges faced, and the scientifi
Background: In light of increasing therapeutic options, risk stratification of advanced cardiac transthyretin amyloidosis (ATTR-CA) is gaining clinical importance to avoid ineffective treatments. Liver stiffness as a marker of hypervolemia and hepatic congestion might predict mortality in advanced ATTR-CA and allow to identify patients at highest risk. Methods: Proven ATTR-CA patients underwent re
Health-related quality of life (HRQL) is a multidimensional concept which captures the individual’s perception of treatment burden. Evaluating HRQL during treatment for childhood cancer provides insight into the burden of the treatment from the child’s and/or parent’s perspective.In this review, we aimed to describe Patient-Reported Outcome Measures (PROMs) used to measure HRQL during treatment, d
INTRODUCTION: Platelet transfusions are frequently used in intensive care unit (ICU) patients, but contemporary epidemiological data are sparse. We aim to present contemporary international data on the use of platelet transfusions in adult ICU patients with thrombocytopenia.METHODS: This is a protocol and statistical analysis plan for a post hoc sub-study of 504 thrombocytopenic patients from the
Background: People with Parkinson’s disease has significant and increasing physical, psychosocial and spiritual needs, as well as problems with coordination and continuity of care. Despite the benefits that palliative care could offer, there is no consensus on how it should be delivered. Aim: The aim of this study is to provide a pragmatic overview of the evidence to make clinical recommendations
In global cities, the impacts of gentrification on the lives and well-being of socially vulnerable residents have occupied political agendas. Yet to date, research on how gentrification affects a multiplicity of health outcomes has remained scarce. While much of the nascent quantitative research helps to identify associations between gentrification and determined health outcomes, it tends to draw
Municipal climate resiliency and re-naturing plans are promoting greening and green (re)development, such as the inclusion of new parks, greenways, or rehabilitated shorelines, frequently as a-political, win-win solutions for all residents. Greenwashing and (re)development of green amenities in vulnerable neighborhoods—those often most in need of support toward resilience and adaptation—expose res
Purpose: Multiple vendors are currently offering artificial intelligence (AI) computer-aided systems for triage detection, diagnosis, and risk prediction of breast cancer based on screening mammography. There is an imminent need to establish validation platforms that enable fair and transparent testing of these systems against external data. Approach: We developed validation of artificial intellig
The Western Gneiss Region (WGR) is a Precambrian basement domain in the Scandinavian Caledonides and one of the world's largest high- and ultrahigh-pressure terranes. The south–central WGR underwent regional eclogite facies metamorphism 415–400 Ma ago when Baltica subducted beneath Laurentia, during the Scandian orogeny. Eclogites in the WGR group into two traditional types: (1) Precambrian mafic
Alternative jet fuels can be radically different from conventional fuels in composition, and the consequences of these differences are a subject of ongoing research. Numerical combustion simulations are vital to this research, and require chemical reaction mechanisms that accurately capture the chemical pathways of combustion. For turbulent combustion, these mechanisms must also be compact and eff
This article introduces a novel testing system for investigating rock hydromechanical behavior with neutron and X-ray imaging techniques. The system comprises four subsystems: an axial compression system, a confining pressure system, a fluid flow system, and a triaxial cell. In order to enable imaging with both modalities to track fluid flow and deformation in situ and 3D, the cell was designed to
Public libraries serve as social infrastructures that foster interpersonal connections and promote well-being and cohesion. In order to explore the role played by libraries in the process of social infrastructuring, we conducted a zine-making workshop with librarians. This workshop facilitated collegial conversations and provided an opportunity for participants to familiarize themselves with the c
A power-series expansion method for approximate analysis of the guided modes in a cylindrical, radially inhomogeneous dielectric waveguide is presented. The method is developed for a piece-wise polynominal permittivity profile. The solution of the scalar wave equation is constructed by a sequence of power-series expantions. Convergence is ensured and accuracy maintained by regulating the distance
