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Objective: North Sea Progressive Myoclonus Epilepsy (NS-PME) is a rare genetic disorder characterized by ataxia, myoclonus and seizures with a progressive course. Although the cause of NS-PME is known, namely a homozygous mutation in the GOSR2 gene (c.430 G>T; p. Gly144Trp), sufficient treatment is lacking. Despite combinations of on average 3–5 anti-seizure medications (ASMs), debilitating myoclo
Introduction Critical care is essential in saving lives of those that are critically ill, however, provision of critical care can be costly and heterogeneous across lower-resource settings. This paper describes the protocol for a systematic review of the literature that aims to identify the reported costs and resources available for the provision of critical care and the forms of critical care pro
We study a simple extension of the Standard Model featuring a dark sector with an ultralight pseudo-Nambu-Goldstone boson as a dark matter candidate. We focus on the mass range O(10-20-10-10) eV, relevant for strong gravity applications, and explore its production and evolution in the early Universe. The model is formulated in such a way that dark matter does not couple directly to photons or othe
OBJECTIVES: Most patients with pancreatic cancer who have undergone surgical resection eventually develop disease recurrence. This study aimed to investigate whether there is evidence to support routine surveillance after pancreatic cancer surgery, with a secondary aim of analyzing the implementation of surveillance strategies in the Nordic countries.MATERIALS AND METHODS: A scoping review was co
We propose a novel hybrid approach that integrates Neural Ordinary Differential Equations (NODEs) with Bayesian optimization to address the dynamics and parameter estimation of a modified time-delay-type Susceptible-Infected-Removed (SIR) model incorporating immune memory. This approach leverages a neural network to produce continuous multi-wave infection profiles by learning from both data and th
How can we talk about musico-dramatic methods and models for operatic acting, and how do these relate to other kinds of acting? Observing the tendency of operatic professionals and pedagogues to import concepts and ideals from theatrical and cinematic practices with non-operatic application of music, we reflect upon what possibilities and problems this discursive choice instils. Interestingly, whiHow can we talk about musico-dramatic methods and models for operatic acting, and how do these relate to other kinds of acting? Observing the tendency of operatic professionals and peda-gogues to import concepts and ideals from theatrical and cinematic practices with non-operatic application of music, we reflect upon what possibilities and problems this discursive choice in-stils. Interestingly, w
PurposeEngagement of non-academic stakeholders is an important element of education for sustainability, but is rarely mentioned in contemporary agricultural education literature. This article investigates the process of engagement of non-academic stakeholders into higher education programs on agriculture. Non-academic stakeholders refer to private firms that are focused on the acquisition of knowl
Introduction: Suturing is a fundamental component of surgical procedures, wherein training emphasises the significance of gentle tissue handling. The suturing process involves the pressure exerted by the forceps onto the tissue, as well as the medial traction force applied to stabilise the tissue during the needle bite. This study examined the forces involved in tissue handling during suturing, co
This paper presents a thorough manufacturing cost analysis for a powder metallurgy (PM) manufactured gear (using press and sintering technique—P/S), through a case study of a R&D 4th drive gear (a helical gearwheel) utilizing both real usage data from six companies and some estimated data from literatures. The chosen costs calculation method, performance part costing (PPC), is comprehensive an
Background. Efforts to identify specific variables that impact most on outcomes from interdisciplinary pain rehabilitation are challenged by the complexity of chronic pain. Methods to manage this complexity are needed. The purpose of the study was to determine the network structure entailed in a set of self-reported variables, examine change, and look at potential predictors of outcome, from a net
Purpose: To evaluate the outcome of referrals for suspected glaucoma based on elevated intraocular pressure (IOP) made by optometric practitioners in Sweden. Methods: This prospective study included 95 individuals referred to the Skåne University Hospital Malmö, Sweden, during 2019, by optometric practitioners, based on elevated IOP. Positive outcome was defined as a diagnosis of glaucoma, or a di
Because the 14C calibration curves IntCal and SHCal are based on data from temperate latitudes, it remains unclear which curve is more suitable for archaeological and paleoenvironmental records from tropical South America. A review of climate dynamics reveals a significant influx of Northern Hemisphere air masses and moisture over a substantial part of the continent during the South American Summe
Scholarly textbooks often follow a logic where suitable empirical cases are selected to illustrate the theoretical and analytical points that we as scholars want to make. But what would happen if we would do the opposite: build a textbook on a novel written by a novelist for such purpose and let the theories explain the actions and emotions of fictional characters? In this article, we share and re
To establish a circular economy in society, it is crucial to incorporate life-cycle studies, such as life-cycle assessment (LCA), in the design process of products in order to mitigate the well-recognized problem of the design paradox. The aim of the study was to provide means in a structured way to highlight choice uncertainty present in LCA when used as decision support, as well as to mitigate s
The aim of this study was to explore how consequences from a university-wide partnership unfolded at various levels within a university and induced intra-organizational dynamics. This was achieved via an in-depth investigation of “The Bridge,” a collaborative partnership between the young mid-range Swedish Linnaeus University (“Average Joe”) and the home furnishing retail giant IKEA, which despite
The Scandinavian region has been at the forefront of energy and environmental policies for decades. While significant effort has been devoted to the supply side and development of technology markets, our study questions the extent to which policy efforts have effectively and explicitly addressed behavioural factors affecting the adoption and the use of low-carbon energy technologies at the individ
Purpose: For primary health care (PHC), hypertension is the number one diagnosis for planned health care visits. The treatment of high blood pressure (BP) and its consequences constitutes a substantial economic burden. In spite of efficient antihypertensive medications, a low percentage of patients reach a well-controlled BP. The PERson-centredness in Hypertension management using Information Tech
