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An on-board measurement system has been developed that in real time identifies the probability for occurrence and also the exact location of severe wear in the wheelrail contact. Noise generated by the wheel-rail contact is a troublesome side effect both when railway vehicles negotiate curves and run on straight tracks. The concept behind this project is to use this noise as an indicator of the tr
An economic model for determining the optimal automation level for discrete batch manufacturing is presented. The model describes how the costs of parts varies between manufacturing systems of different types at differing automation levels, the part costs often being highly dependent upon the automation level selected. The optimal automation level in a given case can be determined using a relative
Accurate delineation of organs at risk (OAR) is a crucial step in radiation therapy (RT) treatment planning but is a manual and time-consuming process. Deep learning-based methods have shown promising results for medical image segmentation and can be used to accelerate this task. Nevertheless, it is rarely applied to complex structures found in the pelvis region, where manual segmentation can be d
Isolation of DNA from blood and buccal swabs in adequate quantities is an integral part of forensic research and analysis. The present study was performed to determine the quality and the quantity of DNA extracted from four commonly available samples and to estimate the time duration of the ensuing PCR amplification. Here, we demonstrate that hair and urine samples can also become an alternate sou
The open source CFD code FireFOAM has been verified and validated against analytical solution and real fire tests. The verification showed that FireFOAM solves the three modes of heat transfer appropriately. The validation against real fire tests yielded reasonable results. FireFOAM has not been validated for a large set of real fires, which is the case for FDS. Therefore, it is the responsibility
RATIONALE: This study aimed to explore whether a computer-based training in eating and nutrition for hospital nursing staff can influence the precision in nutritional treatment and care.METHOD: A pre-intervention and post-intervention study was conducted with a cross-sectional design at each time point. The settings were one intervention (IH) and two control hospitals (CH1 and CH2). Hospital inpat
The aim of this randomized controlled trial was to investigate the effects of guided internet-based cognitive be-havior therapy (ICBT) for posttraumatic stress disorder (PTSD). Sixty-two participants with chronic PTSD, asassessed by the Clinician-administered PTSD Scale, were recruited via nationwide advertising and randomizedto either treatment (n= 31) or delayed treatment attention control (n= 3
This paper presents a bottom boundary layer model for the unsteady and non-uniform flow in the swash zone, by extending the momentum integral method so as to include spatial gradients. The developed model is further incorporated into a hydrodynamic model based on the Nonlinear Shallow Water Equations. Two swash zone cases are examined to investigate the effect of the inclusion of spatial gradients
This paper forms part of a broader study on the design and optimisation of a high speed switched reluctance motor (SRM) for hybrid-electrical automotive traction applications. The main focus of this particular paper is to explain the design optimisation methodology followed. Furthermore, the main aim of the motor design is to push the power density of the SRM as high as possible. This leads to num
In this paper, we introduce a randomized version of the backward Euler method that is applicable to stiff ordinary differential equations and nonlinear evolution equations with time-irregular coefficients. In the finite-dimensional case, we consider Carathéodory-type functions satisfying a one-sided Lipschitz condition. After investigating the well-posedness and the stability properties of the ran
Immersive virtual reality (VR) has been identified as a potentially revolutionary tool for psychological interventions. This study reviews current advances in immersive VR-based therapies for mental disorders. VR has the potential to make psychiatric treatments better and more cost-effective and to make them available to a larger group of patients. However, this may require a new generation of VR
PurposeThis paper aims to investigate the emergence of blockchain-enabled traceability in complex multi-tiered supply chains, focusing on the perspective of upstream suppliers. Blockchain technology receives attention for its potential to enable better traceability and thus sustainability risk management, yet there is limited empirical evidence on how actual implementation unfolds. We aim to under
This article considers students’ and teachers’ perceptions of shared reading (SR) in promoting reading engagement. It provides a thematic analysis of focus groups with students and teachers at a Swedish upper-secondary school who participated in an intervention consisting of SR sessions. The findings are triangulated with a student pre-intervention questionnaire that included reading habits.The st
DNA-encoded chemical libraries are increasingly used in pharmaceutical research because they enable the rapid discovery of synthetic protein ligands. Here we explored whether target-class focused DNA-encoded chemical libraries can be cost-effective tools to achieve robust screening productivity for a series of proteins. The study revealed that a DNA-encoded library designed for NAD+-binding pocket
Male gametogenesis occurs directly after uptake of malaria parasites by the mosquito vector and leads to the release of eight nucleated flagellar gametes. Here, we report that one of the two parasite actin isoforms, named actin II, is essential for this process. Disruption of actin II in Plasmodium berghei resulted in viable asexual blood stages, but male gametogenesis was specifically inhibited.
Quantification of face-to-face interaction can provide highly relevant information in cognitive and psychological science research. Current commercial glint-dependent solutions suffer from several disadvantages and limitations when applied in face-to-face interaction, including data loss, parallax errors, the inconvenience and distracting effect of wearables, and/or the need for several cameras to
Background: Fentanyl is commonly administered for procedural pain management in preterm infants, but target concentrations have not yet been defined. Methods: To investigate pharmacokinetics (PK), -dynamics (PD), and -genetics (PG), 25 infants (gestational age 23.3–34.1 weeks) received a fentanyl dose before a skin-breaking procedure (0.5 µg/kg) or tracheal intubation (2 µg/kg). Four pain scales w
