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Popular Abstract in Swedish Förmågan att planera med en medveten mental simulering har ansetts vara unikt mänsklig sedan Aristoteles. När människor planerar för psykologiska eller fysiologiska driftstillstånd som de för närvarande inte upplever, tror man att de använder sig av så kallad episodisk framförhållning. Den episodiska framförhållningen är en del av det större episodiska kognitiva systemeThe ability to plan for future, not currently experienced, mental or physiological states has been regarded as unique to humans. When humans plan for such states it has been hypothesized that they make use of what has been known as episodic foresight. Episodic foresight is a part of the episodic cognitive system, which also includes episodic memory. The defining feature of this system is so-called

Objective: We used dual X-ray absorptiometry (DXA) to measure calcaneal bone mineral density (BMD) and estimate the prevalence of osteoporosis in a population with distal forearm fracture and a normative cohort. Methods: Patients 20 to 80 years of age with distal forearm fracture treated at one emergency hospital during two consecutive years were invited to calcaneal BMD measurement; 270 women (81

Cerebral ischemia that develops after subarachnoid hemorrhage (SAH) carries high morbidity and mortality. Inflammatory mediators are involved in the development of cerebral ischemia through activation of the mitogen-activated protein kinase pathway. We hypothesized that blockade of the MAPkinase/ERK (MEK)/extracellular signal-regulated kinase (ERK) pathway upstream with a specific raf inhibitor wo

Över 80 000 personer bor på särskilt boende i Sverige. Flytten dit är ofta livets sista och kan medföra psykisk och fysisk påfrestning med risk för depression, försämrad hälsa och för tidig död. Endast personer med omfattande hjälpbehov beviljas plats, och enligt lag får flytten inte ske mot den äldres vilja. Trots ökad skörhet förväntas individen alltså själv ta stort ansvar för flyttprocessen. DMore than 80,000 people live in nursing homes in Sweden. The move isoften the final relocation in life and may involve both psychological andphysical strain, with risks of depression, deteriorating health, and prematuredeath. Only individuals with extensive care needs are granted placement,and by law, the move cannot be made against the will of the older person.Despite increased frailty, individua

We assessed hepatocellular carcinoma (HCC) risk associated with smoking and alcohol consumption and their interactions, using both questionnaire data and objective serum biomarkers. Information on smoking and alcohol consumption was collected at baseline from 450,112 participants of the EPIC cohort, among whom 255 developed HCC after a median follow-up of 14 years. In a nested case–control subset

BACKGROUND: Accurate risk stratification in older adults presenting to the emergency department (ED) is essential but challenging due to atypical presentations and age-related physiological changes. While vital signs are central to triage, their predictive value for short-term mortality in this population remains unclear. This study aimed to explore the association between initial vital signs and

Background: Opioid use disorder is a chronic disorder with a high risk of overdose-related morbidity and mortality where a large proportion of these can be averted by timely administration of the antidote naloxone. For naloxone to be present when and where overdoses occur, broad-scale overdose education and naloxone distribution (OEND) must be established. A regional naloxone program was implement

BACKGROUND: Prior research has established a positive association between the single-measured triglyceride-glucose (TyG) index and hypertension. Nevertheless, longitudinal studies addressing the enduring impact of TyG index on incident hypertension are lacking. This study sought to explore the association between cumulative TyG index (cum-TyG) and incident hypertension, especially obesity-related

AIMS: Metformin has hitherto not been proven superior to other type 2 diabetes (T2D) medications for the prevention of organ complications. The aim of this study is to report baseline data and blinded interim analyses in the register-based randomised clinical trial (RRCT) SMARTEST, which compares metformin and the SGLT2 inhibitor dapagliflozin in early T2D. We also present learnings from the novel

Background: Increasing carbon stock in standing forests is one of the proposed ways to mitigate climate change. However, in production forests, this typically would lead to reduced harvesting possibilities and thus reduced financial gain for the forest owners. The size of this reduction should depend on the chosen target level of the carbon stock as well as the required speed of accumulation. Furt

BackgroundLoss to follow-up (LTFU) from tuberculosis (TB) treatment and care is a major public health problem as patients can be infectious and also may develop a multi-drug resistant TB (MDR-TB). The study aimed to assess whether LTFU differs by the distance TB patients travelled to receive care from the nearest health facility.MethodsA total of 402 patient cards of TB patients who received care

Purpose: Tau pathology is associated with concurrent atrophy and decreased cerebral blood flow (CBF) in Alzheimer’s disease (AD), but less is known about their temporal relationships. Our aim was therefore to investigate the association of concurrent and longitudinal tau PET with longitudinal changes in atrophy and relative CBF. Methods: We included 61 individuals from the Amsterdam Dementia Cohor

Objective: To implement artificial neural network (ANN) algorithms for noninvasive lymph node staging (NILS) to a decision support tool and facilitate the option to omit surgical axillary staging in breast cancer patients with low-risk of nodal metastasis. Methods: The NILS tool is a further development of an ANN prototype for the prediction of nodal status. Training and internal validation of the

Importance: We know little about the transmission of obsessive-compulsive disorder (OCD) across generations. Objective: To evaluate the sources of parent-offspring transmission of OCD and familial cross-generational association with more typical anxiety disorders. Design, Setting, and Participants: This Swedish population register-based study analyzed data for offspring born in Sweden from 1960 to

Estimates of land-atmosphere exchanges of carbon, energy, water vapor, and other greenhouse gases based on the eddy covariance (EC) technique rely on the fundamental assumption that the flux footprint area is homogeneous. We investigated the impact of source area heterogeneity on flux estimates in single-level EC measurements over a managed boreal forest landscape. For this purpose, we compared si

Introduction: Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between s

Aims/hypothesis: Low birthweight is a risk factor for type 2 diabetes but it is unknown whether low birthweight is associated with distinct clinical characteristics at disease onset. We examined whether a lower or higher birthweight in type 2 diabetes is associated with clinically relevant characteristics at disease onset. Methods: Midwife records were traced for 6866 individuals with type 2 diabe

Purpose: This study aimed to quantify the relationship between objective and subjective measures of functional ability and determine if measures in the deficient (ACLd) state were correlated to, and capable of predicting a patient's objective and subjective measures in the reconstructed (ACLr) state. Methods: Twenty ACL-injured participants completed hop and side cut movements prior to and 10 mont

Background: Violence due to firearms is a major global public health issue and vascular injuries from firearms are particularly lethal. The aim of this study was to analyse population-based epidemiology of firearm-related vascular injuries. Methods: This was a retrospective nationwide epidemiological study including all patients with firearm injuries from the national Swedish Trauma Registry (SweT