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With older and aging populations, patients experience multiple chronic diseases at the same time. Individual chronic disease guidelines often recommend pharmacological therapies as a key intervention, resulting in patients being prescribed multiple regular medications for their different diseases. Although the term “polypharmacy” has been applied to the use of multiple medications, there is no con
Background Clinical health promotion significantly improves treatment outcomes in hospitals and health services on both long and short term. Therefore, the World Health Organization (WHO) and the International Network of Health Promoting Hospitals & Health Services (HPH) developed and validated three easy-to-use tools that have been implemented by many national, regional and local health care
In the Nordic countries, university language policy and planning centres on balancing the use of the national language(s) vis-à-vis English, whereas less attention has been paid to the roles played by other languages. This study focuses on how space was negotiated for languages other than Swedish and English during language policy negotiations at a Swedish university. Using an ethnographic discour
OBJECTIVES: The predictive ability of the STarT Back Tool (SBT) has not yet been examined among acute/subacute back and/or neck pain in a primary care setting in respect to health-related quality of life (HRQoL) and work ability outcomes. The aim of this study was to evaluate the SBT's predictive validity for HRQoL and work ability outcomes at long-term follow-up in a population with acute/subacut
Abstract: Cardiovascular diseases and diabetes mellitus are closely linked by sharing common risk factors, such as obesity, insulin resistance, hypertension and dyslipidaemia. These intermediate risk factors are affected by the joint effects of environment and genetics. Although a multitude of studies aimed to disentangle the effects of gene-environment interactions, many of the published gene-en
Chronic airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), together with their comorbidities, bear a significant burden on public health. Increased appreciation of molecular networks underlying inflammatory airway disease needs to be translated into new therapies for distinct phenotypes not controlled by current treatment regimens. On the other hand, development of ne
Chemogenetics is the process of genetically expressing a macromolecule receptor capable of modulating the activity of the cell in response to selective chemical ligand. This chapter will cover the chemogenetic technologies that are available to date, focusing on the commonly available engineered or otherwise modified ligand-gated ion channels and G-protein-coupled receptors in the context of neuro
We present measurements of elliptic and triangular azimuthal anisotropy of charged particles detected at forward rapidity 1
Mexico is the most transited corridor in the world. Beyond borderlands, human rights abuses committed against migrants pervade across transit communities and routes. In the interior of Mexico, not only at borders, the criminalization of migration has occurred having as a backdrop violence, xenophobia and insecurity in transit communities. Transit communities have developed complex relationships wi
A diversity of softwood lignin depolymerization processes yield guaiacol as the main low molecular weight product. This key aromatic compound can be utilized as a carbon source by several microbial species, most of which are Gram positive bacteria. Microbial degradation of guaiacol is known to proceed initially via demethylation to catechol, and this reaction is catalyzed by cytochrome P450 monoox
This paper deals with the joint estimation of spatial mode shapes and temporal frequencies from transient vibrations measured by a uniform circular array of sensors encircling a cross-section of a cylinder. The geometry allows each 2D mode to be interpreted as two real planar waves impinging from mirrored directions with respect to the broadside of a uniform linear array. Algorithms for joint esti
Popular Abstract in Swedish Denna avhandling presenterar nya metoder för att analysera bilder på hjärtat för att utesluta eller bekräfta kranskärlssjukdom. Hjärtat har en livsviktig uppgift, att pumpa runt blodet för att förse alla kroppens organ med energi och syre. Vid förträngningar i kärlen som försörjer hjärtmuskeln med blod (kranskärlen) uppkommer ett tillstånd som kallas ischemisk hjärtsjukIn this thesis, methods for automated analysis of myocardial perfusion single photon emission computer tomography (myocardial perfusion SPECT, MPS) images have been successfully developed and evaluated. MPS images show the perfusion of the myocardium and are used for diagnosing patients with suspected ischemic heart disease. The disease is characterized by reduced perfusion to a region of the myoc
This work concerns two-dimensional numerical simulations of the flow and temperature fields inside smooth and ribbed bend (turn) parts of a U-duct with relevance for internal tip cooling of gas turbine blades. The ribs are placed internally on the outermost bend surface. The renormalization group (RNG) k-epsilon turbulence model was used to solve the momentum and energy equations inside the bend (
Popular Abstract in Swedish En ny metod för att syntetisera avancerade kolhydrater har utvecklats. I en utvärdering har två kolhydratstrukturer, viktiga intermediat i ett nytt cancervaccin, syntetiserats.A novel promoter system IX/AgOTf (X=Cl or Br) for thioglycoside activation has been developed (paper I-II). The promoter system has been evaluated in the synthesis of two GD3 bis-lactam fragments (paper III).
An L1 adaptive controller of piecewise constant type has been applied to a fighter aircraft by augmenting it to a linear state-feedback controller. Angle of attack and sideslip as well as velocity vector roll rate is demanded and controlled. It is relatively easy to design a controller augmentation this way; few parameters need to be tuned. To design an L1-controller for roll/pitch/yaw-motion of a
The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA - dis
