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Background: The TrialNet Oral Insulin (OI) prevention trial showed no overall treatment effect, using the diagnosis of type 1 diabetes as an endpoint. A significant delay in onset was only found in a high-risk stratum (termed secondary stratum 1) of participants with low first-phase insulin release (FPIR).Methods: Since trials with an endpoint of type 1 diabetes take years to complete, in this pos
The aim of this paper is directly linked to the context within which it has been drafted, as ecological debt (including climate debt) has been identified as a key Ejolt concept, one that is in need of better elucidation if EJOs are to operationalize its possibilities in their ongoing activities. Readers of this paper (and especially EJO activists) should in this way not only find themselves introd
No abstract. Prepared for Linnédelegationen, Stockholm, Sweden.
Objectives: In patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) initiating secukinumab, we aimed to assess and compare the proportion of patients achieving 6-, 12- and 24-month patient-reported outcomes (PRO) remission and the 24-month retention rates. Patients and methods: Patients with axSpA or PsA from 16 European registries, who initiated secukinumab in routine care w
BACKGROUND: Anastomotic leakage after anterior resection for rectal cancer is more common after total mesorectal excision compared to partial mesorectal excision but might be mitigated by a defunctioning stoma. OBJECTIVE: The aim is to assess how anastomotic leakage is affected by type of mesorectal excision and defunctioning stoma use. DESIGN: This is a retrospective multicenter cohort study eval
Oxygen isotopes in biogenic silica (δ18OBSi) from lake sediments allow for quantitative reconstruction of past hydroclimate and proxy-model comparison in terrestrial environments. The signals of individual records have been attributed to different factors, such as air temperature (Tair), atmospheric circulation patterns, hydrological changes, and lake evaporation. While every lake has its own loca
I Danmark reguleres det sociale område i høj grad af rammelovgivning, som uddelegerer myndighed, regulerer gennem formålsbeskrivelser og gør det muligt for såkaldte velfærdsprofessionelle at udøve skøn. Denne artikel undersøger, hvordan samspillet mellem velfærdsprofessionelles opfattelser og de ting, der på forskellig vis regulerer deres praksis, får betydning for konstruktionen af legalitet i de
Large-scale landforms originated from jökulhlaups or glacial lake-outburst floods (GLOFs), and their small-scale components help in recognising the sedimentary environment of the flood. The GLOF fans that developed along the Pleistocene ice-sheet margin have not been investigated in detail, and north-eastern Poland, with its Megaflood Landform System and Bachanowo and Szeszupka fans, seems ideal f
Background: Propionic acid fermentation from renewable feedstock suffers from low volumetric productivity and final product concentration, which limits the industrial feasibility of the microbial route. High cell density fermentation techniques overcome these limitations. Here, propionic acid (PA) production from glucose and a crude glycerol/glucose mixture was evaluated using Acidipropionibacteri
Design of inhalable mRNA therapeutics is promising because local administration in the respiratory tract is minimally invasive and induces a local response. However, several challenges related to administration via inhalation and respiratory tract barriers have so far prevented the progress of inhaled mRNA therapeutics. Here, we investigated factors of importance for lipid nanoparticle (LNP)-media
Remote sensing precipitation data have the characteristics of wide coverage and revealing spatiotemporal information, but their spatial resolution is low. The accuracy of the data is obviously different in different study areas and hydrometeorological conditions. This study evaluated four precipitation products in the Yellow River basin from 2001 to 2019, constructed the optimal combined product,
In November 2022 the European Commission launched a new regulatory framework proposal for packaging and packaging waste, EU Packaging and Packaging Waste Regulation, which includes mandatory reuse and refill targets of packed food products. With specific focus on perishable liquid food products, such as dairy, plant-based beverages, juices, and nectars, which are currently primarily available in s
The sometimes rapid development of (new) threats and extraordinary events calls for a robust, flexible, and well-equipped civil crisis preparedness system to respond and limit the damage of crisis events. To achieve this, Swedish municipalities and regions are required by law to regularly perform and report risk and vulnerability analysis ‘bottom up’ to governmental agencies. When performed in lar
