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A rapid and sensitive liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the qualitative and quantitative assay of cyproheptadine (CP) in pharmaceutical samples. Diphenylpyraline hydrochloride (DPP) was used as an internal standard (IS). Two multiple reaction-monitoring (MRM) transitions for each analyte were observed: 288.1/96.1 and 288.1/191.2 for
The human ribosomal protein S19 gene (RPS19) is mutated in approximately 20% of patients with Diamond-Black fan anemia (DBA), a congenital disease with a specific defect in erythropoiesis. The clinical expression of DBA is highly variable, and subclinical phenotypes may be revealed by elevated erythrocyte deaminase (eADA) activity only. In mice, complete loss of Rps19 results in early embryonic le
Dactylorhiza traunsteineri is an allotetraploid species that belongs to the large Dactylorhiza incarnata/maculata polyploid complex of the Eurasian genus Dactylorhiza (Orchidaceae). Here, eight polymorphic microsatellite loci were isolated using selective hybridization according to the FIASCO protocol (fast isolation by AFLP of sequences containing repeats) with slight modifications. The number of
It has been suggested that tryptophan 563 is sandwiched between residues R562 and A532 in Bruton's agammaglobulinemia tyrosine kinase (Btk). Mutations of the surrounding residues have been shown to cause X-linked agammaglobulinemia. Substitutions R562P and A582V were noticed to have impaired kinase activity. However, based on Western blot analysis, the mutant proteins were expressed at normal leve
Biogas production in anaerobic digestion in farm-scale units is typically performed under mesophilic conditions when used for producing domestic fuel and stabilizing animal waste for the use of digested manure as a fertilizer. Previous studies on the digestion of llama and cow manure have shown the feasibility of producing biogas under altiplano conditions (low pressure and low temperature) and of
PURPOSE: The purpose of this study is to investigate the results of first-time surgery for sporadic primary hyperparathyroidism (pHPT) in patients with preoperatively negative sestamibi scintigraphy and ultrasound. METHODS: Data were gathered prospectively in a multicenter database for quality control in parathyroid surgery. Between 2004 and 2008, 3,158 patients underwent first-time surgery for sp
This thesis addresses the corporate sustainability process and different tools to assist the process of generating corporate strategies towards sustainability in the energy sector. The focus of the research was in backcasting approaches. The main outcome of the work is a framework for corporate sustainability for the energy sector. The framework is constructed around a three step strategic plannin
Neural transplantation is over a century old, but the modern era encompasses only the last 30-40 years. For most of this time period, research has focused on reversing disability engendered by neurologic disease and brain damage. Only recently was it recognized that the underlying neurological disease itself might negatively impact the grafted neurons. We have found that a subset of neurons within
Radiative lifetimes for the levels of the 3s(2)3p(2)4p configuration in neutral phosphorus have been determined experimentally for the first time and also theoretically. Experiments were performed by using two-photon UV laser excitation and subsequent fluorescence detection in a laser-produced plasma. In relativistic Hartree-Fock calculations, the Cowan code extended to 42 configurations was used.
The aim of this study was to demonstrate safe orthotopic transplantation of porcine donor hearts harvested 24 hours after brain death and preserved for 24 hours before transplantation.
The function of the immune system requires coordinated expression and action of many genes and proteins. With the emergence of high throughput technologies it has become possible to target human immunity from a systems biology point of view. To perform systems biology studies with comparable results we need not just a reference gene and protein set but also useful and descriptive reference categor
BACKGROUND AND PURPOSE: Previous reports concerning sex-related differences in stroke management and outcome are inconsistent and are sometimes difficult to interpret. We used data from a national stroke register to further explore possible differences between men and women in baseline characteristics, stroke treatment, and outcome. METHODS: This study included 24 633 stroke events registered in R
Popular Abstract in Swedish Sedan människan lyckades skapa eld har förbränning utgjort den viktigaste energikällan i mänsklighetens långa historia, viket den ser ut att fortsätta vara det inom en överskådlig framtid. I dagsläget kommer mer än 90% av vår energi från förbränningsprocesser. Dock uppstår en rad problem kring förbränning, såsom föroreningar och möjligheten till använda sig av förnyelseNowadays, more than 90% of our energy comes from combustion processes. Hence, it is very important to perform combustion research to reduce emissions, improve efficiency, find clean and renewable fuels, strengthen safety, etc. The complexity of combustion processes asks for advanced diagnostic tools, among which the laser spectroscopy has been proved to be a powerful one. This thesis is about the
High-temperature catalytic processes such as partial oxidation of Methane (POX) and steam Methane reforming (SMR) may benefit from use of reactor systems using monolithic honeycomb structures. Hereby, process performance is enhanced through more efficient heat transfer and considerable smaller reactor foot-prints than for conventional reactor concepts. Compact ceramic heat exchange structures may
The damage caused by the worldwide increase in natural disasters is staggering, with the poor and marginalised slum communities being the most vulnerable. This paper analyses the key variables and their causal relations underlying the complex system of risk and disaster occurrence in slum areas in El Salvador. Slum dwellers’ views and knowledge are the focus of this inquiry. A better understanding
