Filtyp
Discrete Time Markov Chains (DTMCs) and Con- tinuous Time Markov Chains (CTMCs) are often used to model various types of phenomena, such as, for example, the behavior of software products. In that case, Markov chains are widely used to describe possible time-varying behavior of “self-adaptive” software systems, where the transition from one state to another represents alternative choices at the so
Rationale and Objectives: To compare the ability of normalized versus non-normalized metabolite ratios to differentiate recurrent brain tumor from radiation injury using magnetic resonance spectroscopy (MRS) in previously treated patients. Materials and Methods: Twenty-five patients with previous diagnosis of primary intracranial neoplasm confirmed with biopsy/resection, previously treated with ra
A series of aromatic multiblock copolymers based on alternating segments of hydrophilic sulfonated polysulfone (PSU) and hydrophobic polyfluoroether (PFE) were prepared and characterized as proton exchange membranes. PSU precursor blocks were synthesized by polycondensation of dichlorodiphenylsulfone and resorcinol, and PFE precursor blocks were prepared by combining decafluorobiphenyl and isoprop
The Middle East, home to 6.3 percent of the world’s population and containing only 1.4 percent of the world’s renewable fresh water, is experiencing an increasing water scarcity crisis.1 The UN presented an alarming report during the last World Water Forum in March 2009 painting a bleak picture of increasing demand and diminishing water supplies.2 Scientifically, the Middle East ran out of water i
In recent years, dynamical modelling has been provided with a range of breakthrough methods to perform exact Bayesian inference. However, it is often computationally unfeasible to apply exact statistical methodologies in the context of large data sets and complex models. This paper considers a nonlinear stochastic differential equation model observed with correlated measurement errors and an appli
Akt (also known as PKB) is a survival kinase frequently up-regulated in cancer; three isoforms of Akt exist, and among them Akt1 and Akt2 are the most widely and highly expressed. They share the same structure and activation mechanism and have many overlapping functions; nevertheless isoform-specific roles and substrates have been reported, which are expected to rely on sequence diversities. In pa
We examine the applicability of the extended law of corresponding states (ELCS) to equilibrium and non equilibrium features of the state diagram of the globular protein lysozyme. We provide compelling evidence that the ELCS correctly reproduces the location of the binodal for different ionic strengths, but fails in describing the location of the arrest line. We subsequently use Mode Coupling Theor
The best valve substitute for aortic valve replacement (AVR) in terms of hemodynamic performance, durability, incidence of complications, and survival remains the subject of much debate. It has been suggested that valve performance is influenced by the potentially modifiable variable prosthesis-patient mismatch (PPM). PPM has been reported to be detrimental for survival and symptom resolution main
There is a need to closer characterise the molecular changes associated with progression from low to high mortality stage cutaneous T cell lymphoma. This has been challenging since there is high inter-patient heterogeneity in the genetics and transcriptomics of the malignant T cell populations. Modern technology has enabled single-cell resolution as well as spatially guided cell selection for whol
The purpose of this research was to examine existing governance arrangements within the Australian federal public service and possible improvements for managing systemic risks at a national level. While there has been greater attention and discussion on systemic risks recently, research on how to govern systemic risk remains in its infancy. Where systemic risk governance is discussed, it is genera
Major depressive disorder (MDD) is a prevalent psychiatric condition and poses a significant burden on public health. The underlying causes and mechanisms of depression remain poorly understood. There is a growing body of evidence linking microRNAs (miRNAs) to major depressive disorder (MDD). However, the causal relationship between miRNAs and MDD remains unclear. This study aimed to investigate t
Cultural values and beliefs within the jazz community have intrigued social scientists for a long time. Being one of the oldest recognised subcultures, jazz has been celebrated for its socio-political ambitions as well as the complexity and aesthetics of the music itself. Being recognised as an outlet for fighting social injustices throughout history, the notable exclusion of female jazz musicians
Consumers evaluate each step of their journey, which influences consumer’s expectations for further experiences and future intentions. Accordingly, past experiences are stored in consumers’ memory but each part of the journey will not be remembered. What drives further behaviours and intentions are the events of the experience that are considered more emotional and atypical, also called peaks. The
Tropical rainforests cover large parts of the Democratic Republic of Congo. In light of recent surges in deforestation in the country, protected areas are a decisive component of the national conservation strategy. Intended to preserve ecosystems, the way in which these areas are organized can have vital implications for people who reside within them through the changes they cause to environmental
Strategic communication as an integrating discipline addresses social phenomenon as migration. When people relocate, they experience physical and mental stress, and seek guidance, questioning their sense of belonging. Authentic communication based on feminist values aims to build long-lasting relations and reach social inclusion by conducting more sensitive communication. This thesis explores the
The axiom of transitivity states that if a person prefers option A to B and B to C, he must also prefer A to C. This simple axiom is often seen as one of the pillars of rational choice, but whether it should be has created a divide in the research community. Some state that there cannot be rational choice or utility without transitivity and that agents who present intransitive preferences allow th
This study is evaluating two methods in order to calculate predicted no effect concentrations (PNECs) used in environmental risk assessment for three chemicals (α-Amylcinnamaldehyde, 1-tridecanol and paracetamol). The methods used are Species Sensitivity Distributions (SSD) and the guideline from European Chemicals Agency (ECHA): “Guidance on information requirements and chemical safety assessment
Lumazine Synthase forms pentamers, C5 in some organism and icodahedra, Ih in other. The aim of this project is to investigate which evolutionary steps could have led the pentamers to assembly into icosahedral capsids. Therefore prevoius work has been performed to reconstruct ancestral sequences for the pentameric and icosahedral forms of Lumazine Synthase. The icosahedral sequence had been express
To allow further device scalability within the data storage industry there needs to be continued research of new technologies. One promising technology is the Magnetic Random Access Memory (MRAM), based on magnetoresistive elements, which is non-volatile; consume low power and have fast read and write operations. To make the technology scalable, the bit (the smallest element in the MRAM) needs to
