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Aberrant stem cell-like gene regulatory networks are a feature of leukaemogenesis. The ETS-related gene (ERG), an important regulator of normal haematopoiesis, is also highly expressed in T-ALL and acute myeloid leukaemia (AML). However, the transcriptional regulation of ERG in leukaemic cells remains poorly understood. In order to discover transcriptional regulators of ERG, we employed a quantita

The receptor tyrosine kinase FLT3 is expressed almost exclusively in the hematopoietic compartment. Binding of its ligand, FLT3 ligand (FL), induces dimerization and activation of its intrinsic tyrosine kinase activity. This leads to autophosphorylation of FLT3 on several tyrosine residues which constitute high affinity binding sites for signal transduction molecules. Recruitment of these signal t

Human kallikrein peptidase 2 (hK2) is a prostate specific enzyme whose expression is governed by the androgen receptor (AR). AR is the central oncogenic driver of prostate cancer (PCa) and is also a key regulator of DNA repair in cancer. We report an innovative therapeutic strategy that exploits the hormone-DNA repair circuit to enable molecularly-specific alpha particle irradiation of PCa. Alpha-

Background: Tyrosine kinase inhibitors (TKIs) have improved the survival of patients with chronic myeloid leukaemia. Many patients have deep molecular responses, a prerequisite for TKI therapy discontinuation. We aimed to define precise conditions for stopping treatment. Methods: In this prospective, non-randomised trial, we enrolled patients with chronic myeloid leukaemia at 61 European centres i

We report an improved separation method for the isolation of sperm cells from dilute, "large volume" samples containing female DNA using bead-assisted acoustic trapping. In an enclosed glass-PDMS-glass (GPG) resonator, we exploit a three-layer microfluidic architecture to generate "trapping nodes" in ultrasonic standing waves. We investigate the dependence of trapping efficiency on particle concen

To investigate the symbiotic interaction of Trichoderma harzianum Rifai on Chenopodium quinoa Willd. in isolation, we studied axenic co-culture of the T. harzianum isolates T-22 and BOL-12QD and the C. quinoa cultivars Kurmi and Maniqueña real. Neither T-22 nor BOL-12QD affected seedling growth during two days of co-culture in the early growth phase of rapid primary root extension. However, after To investigate the symbiotic interaction of Trichoderma harzianum Rifaion Chenopodium quinoa Willd. in isolation, we studied axenic co-culture of the T. harzianum isolates T-22 and BOL-12QD and the C. quinoa cultivars Kurmi andManiqueña real. Neither T-22 nor BOL-12QD affected seedling growth during two days of co-culture in the early growth phase of rapid primary root extension.However, after lon

Protein biomarkers for epithelial ovarian cancer are critical for the early detection of the cancer to improve patient prognosis and for the clinical management of the disease to monitor treatment response and to detect recurrences. Unfortunately, the discovery of protein biomarkers is hampered by the limited availability of reliable and sensitive assays needed for the reproducible quantification

Single-cell RNAseq is a routinely used method to explore heterogeneity within cell populations. Data from these experiments are often visualized using dimension reduction methods such as UMAP and tSNE, where each cell is projected in two or three dimensional space. Three-dimensional projections can be more informative for larger and complex datasets because they are less prone to merging and flatt

Introduction: The purpose of this study was to experimentally investigate the effects of changes in both quantity and quality of use of social networking sites (SNS) on measures of anxiety, depression, stress, self-esteem, loneliness, problematic social media use, and present focused awareness. Method: Participants were randomly assigned to three different conditions: reducing SNS time to 30 minut

The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on the world of sports due to periods of home quarantine, bans against public gatherings, travel restrictions, and a large number of postponed or canceled major sporting events. The literature hitherto is sparse, but early indications display signs of psychological impact on elite athletes due to the pandemic. However, b

Well-characterized archival formalin-fixed paraffin-embedded (FFPE) tissues are of much value for prospective biomarker discovery studies, and protocols that offer high throughput and good reproducibility are essential in proteomics. Therefore, we implemented efficient paraffin removal and protein extraction from FFPE tissues followed by an optimized two-enzyme digestion using suspension trapping

A high acoustic energy density is required in the acoustic resonator to increase the throughput of acoustophoresis devices. In this study, through both experiments and numerical simulations, we find that the energy density in bulk-wave-acoustophoresis devices can be enhanced by actuating the device from the side. Based on qualitative free-flow focusing experiments, side actuation shows clear super

FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces dimerization and activation of its intrinsic tyrosine kinase activity. Activation of FLT3 leads to its autophosphorylation and initiation of several signal transduction cascades. Signaling is initiated by the recruitment of sig

Abstract to PLANNORD 2019: Future challenges for Nordic planning

Colorectal cancer (CRC) is the third most prevalent cancer worldwide causing an estimated 700 000 deaths annually. Different types of treatment are available for patients with advanced metastatic colorectal cancer, including targeted biological agents, such as cetuximab, a monoclonal antibody that targets EGFR. We have previously reported a study indicating multiple levels of interaction between m

Årskurs: F-9 Ämnesområde: Kraft och rörelse  Galileo Galileo, även kallad "Den naturvetenskapliga metodens fader", lär ha släppt en större och en mindre kanonkula från lutande tornet i Pisa. Till åskådarnas förvåning landade de olika tunga kloten samtidigt i marken. Ett klassiskt experiment som visar på en grundläggande egenskap hos gravitationen/tyngdkrafen: Att alla föremål accelererar lika snab

https://www.nrcf.lu.se/lararresurser/lararresurser-fran-o/e-f/fritt-fall-systematiska-undersokningar - 2026-04-21

Dina pengar – med och utan kollektivavtal Ta gärna reda på mer om olika kollektivavtalade förmåner genom att besöka saco.se, knegdeg.se, ersatt- ningskollen.se och minpension.se. Illustration: Kari Modén Uppdaterad jan 2022 Kollektivavtal – din försäkring genom hela karriären Den här skriften är för dig som är akademiker och som vill veta mer om vad ett kollektivavtal är och vad det kan betyda för

https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/goteborgs-universitet/dokument/2022-dina-pengar.pdf - 2026-04-21