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Vascular smooth muscle phenotype is regulated by environmental factors, such as mechanical forces, which exert effects on signaling to differentiation and growth. We used the mouse portal vein in organ culture to investigate stretch-dependent activation of Akt, extracellular regulated protein kinase (ERK) and focal adhesion kinase (FAK), which have been suggested to be involved in the regulation o
A number of optically pure 1,3-diols have been synthesized and used as catalysts in the asymmetric addition of diethylzinc to aromatic aldehydes. Enantiomeric excesses of up to 92% of (R)-1-phenylpropan-1-ol were obtained with anisylbicyclo[2.2.2] octanediol (14) as a catalyst. Using 2-picolylbicyclo[ 2.2.2] ocatanediol (16) as the catalyst resulted in a reversal of the stereoselectivity, yielding
The objective of this paper is to describe the evaluation and effects of a major reconstruction of an arterial street in Eskilstuna, a medium sized Swedish town. The aim of the reconstruction was to minimize the barrier effects of the arterial street and by that create a stronger connection between the town center, on one side of the street, and the town-river, on the other; but also to create gen
Popular Abstract in Swedish Avhandlingen är en granskning av ett antal psykologiska metoder i syfte att förbättra bedömning/diagnostik av två olika tillstånd förknippade med kontakt med kemikalier: (1) kronisk nedsättning av hjärnfunktion till följd av långvarig kontakt med lösningsmedel i yrket (toxisk encefalopati, förkortat TE), och (2) överkänslighet för kemikalielukter av okända orsaker (eng.The dissertation deals with psychological methods aimed at improving the understanding and assessment of two disorders related to contact with chemicals: solvent-induced chronic toxic encephalopathy (TE) and multiple chemical sensitivity (MCS). The main aim of Paper I was to study whether the addition of some newer psychological tests of complex attention and executive functions to a traditional
Packaging and the role it plays in supply chain efficiency is overlooked in most design and development research. An opportunity exists to meet the needs of supply chains to increase efficiency. This research presents three propositions on how to reduce the gap between supply chain needs and satisfaction in interaction with the product and packaging system. It also proposes a supply chain focused
Popular Abstract in Swedish Med dagens alla transporter finns det ett mycket stort behov av tillgång till billigt och miljövänligt drivmedel. Det bränsle som används i särklass mest är bensin framställd från råolja. Ett problem med bensinen är att den inte tillverkas från förnyelsebara råvarukällor. Detta innebär att när oljan tar slut så går det inte att tillverka mer bensin. Däremot är det idag In order to produce fuel ethanol from lignocellulose, it is necessary to hydrolyse the sugar-containing constituents hemicellulose and cellulose. During acid hydrolysis, a number of compounds are formed or liberated in addition to the fermentable monomeric sugars. Several of these compounds might act as inhibitors during the fermentation of the sugars to ethanol. Thus, in order to obtain high etha
During recent years we have seen several large-scale crises. The 9/11 terror attacks, tsunamis, storms, floods and bombings have all caused a great deal of damage. A common factor in these crises has been the need for information and one important source of information is usually Web sites. In this work we investigate and design an overload control system for Web sites that are vital in crises. Th
In very-large multiple-input multiple-output (MIMO) systems, the BS (base station) is equipped with very large number of antennas as compared to previously considered systems. There are various advantages of increasing the number of antennas, and some schemes would require handling large matrices for joint processing (pre-coding) at the base station. The dirty paper coding (DPC) is an optimal pre-
The innovation process is a challenge for companies trying to achieve better outcomes through new ideas or products. The related literature discusses the importance of innovation as a learning process, underlined by a design perspective. Supported by design, the innovation process combines multidisciplinary aspects of creativity and dynamism, mainly for end-user oriented industries. For other indu
A highly optimized Monte Carlo (MC) code package for simulating light transport is developed on the latest graphics processing unit (GPU) built for general-purpose computing from NVIDIA - the Fermi GPU. In biomedical optics, the MC method is the gold standard approach for simulating light transport in biological tissue, both due to its accuracy and its flexibility in modelling realistic, heterogen
Plug-and-Produce (with the meaning that devices can be plugged in without any manual configurations needed) is an attractive paradigm for manufacturing systems, and in particular for Small and Medium Enterprises (SMEs) that do not have the expertise of system integrators but do need to be able to reconfigure their systems by themselves. One approach for loosely (in terms of timing) coupled devices
Summary of key messages for policy makers • Systemic approach is critical Climate change and natural resource depletion continues to be driven not least by unsustainable levels and patterns of consumption. There is growing recognition that the shift required to achieve sustainable consumption and production is a momentous paradigm shift in Western culture. Due to the holistic nature of shifting c
Antibody-based microarrays have emerged as an established proteomic technology allowing multiplexed and sensitive profiling of complex proteomes, in a high-throughput and miniaturized manner. Recently, numerous applicative efforts have been pursued generating disease-associated protein signatures that now could be further explored for improved disease diagnostics, prognostics and classification.
