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Due to increasing awareness and consumer demands it has become important for companies to develop an economical and environmentally sustainable alternative to traditional petroleum-based plastics. The transition from fossil material to bio based is important for the future of people and planet, still, how the transformation should be implemented is yet unknown. In this report, the possibilities of
The Large Hadron Collider (LHC) at CERN is undergoing a major upgrade to prepare for the High-Luminosity LHC. It will allow for many more particle collisions to occur. Some detectors that make up the LHC experiments must be replaced to withstand the harsher conditions. In particular, the inner tracking detector (ID) of the ATLAS experiment will be replaced by the new Inner Tracker (ITk). Every co
Due to increasing global energy demands and a need to move away from non-renewable energy sources, green hydrogen is now being considered as a possible replacement for fossil-based energy sources. Especially in “hard-to-abate” sectors, such as steel and petrochemical production, and long-distance transport, where the change to renewable electricity is more difficult. Green hydrogen is produced thr
A lack of somatostatin expressing interneurons (SST INs) is known to be a factor in several neurodegenerative and neurospsychiatric diseases, such as Alzheimer disease, Parkinson’s disease and schizophrenia. Being able to efficiently obtain SST INs in vitro could enable a greater understanding and better treatment of these diseases. The development of SST INs is not yet fully understood, but it is
The use of antenna arrays allows for direction-of-arrival (DoA) estimation in a radar system. The antenna elements in an array are conventionally positioned equidistantly on a grid, but they can also be placed relatively freely to form sparse antenna arrays. These non-conventional layouts could potentially offer improved DoA capabilities. In this work, a particle swarm optimization algorithm has b
High-Level Synthesis(HLS) is a design methodology that enables designers to implement hardware from high-level coding languages, such as C, C++, or System C. It provides designers with the ability to convey their design at a higher level of abstraction, which allows more emphasis on an algorithm and functional aspects of design instead on low-level hardware details. As precise control of signal ti
This thesis studied the recording methodologies of conducting unannounced evacuation drills to enhance the understanding of evacuation behaviours and performance within the Complex Muon Solenoid (CMS) cavern at CERN. The primary objective was to validate the CMS underground evacuation simulation model for planned evacuation and compare various data collection methods. An unannounced evacuation dr
Preeclampsia (PE) occurs in up to 5% of worldwide pregnancies. It is a complex disease characterised by sudden onset hypertension, and it is harmful to the mother as well as the growing baby, accounting for 40% of fetal deaths worldwide. The disease can be divided into early and late-onset PE, defined as diagnosis earlier or later than 34 weeks of gestation. Despite decades of research, the cause
To describe the relatives' experiences of information and support while heart or lung transplant candidates were waiting for a transplantation.
The Matern covariance function is a popular choice for modeling dependence in spatial environmental data. Standard Matern covariance models are, however, often computationally infeasible for large data sets. Recent results for Markov approximations of Gaussian Matern fields based on Hilbert space approximations are extended using wavelet basis functions. Using a simulation-based study, these Marko
Previous studies have shown that fossil energy systems can be a conflict objective, means or cause. This study explores how renewable energy (RE) systems can interact with conflicts and to what extent the risk of different conflicts may change. Renewable resources, in contrast to conventional fossil resources, are more difficult to control in time and space. RE systems depend on exploiting flows r
The synthesis of four molybdenum and tungsten complexes bearing tetradentate tripodal amino bisphenolate ligands with either hydroxyethylene (1a) or hydroxyglycolene (1b) substituents is reported. The molybdenum dioxo complexes [MoO2L] (L = 2a, 2b) and tungsten complexes [WO2L] (3a, 3b) were synthesized using [MoO2(acac)(2)] and [W(eg)(3)] (eg = 1,2-ethanediolato, ethylene glycolate), respectively
It is of highest importance to find proteins responsible for breast cancer dissemination, for use as biomarkers or treatment targets. We established and performed a combined nontargeted LC MS/MS and a targeted LC SRM workflow for discovery and validation of protein biomarkers. Eighty breast tumors, stratified for estrogen receptor status and development of distant recurrence (DR +/-), were collect
This review will discuss methodologies and applicability of key inflammatory models of respiratory disease in proof of concept or proof of efficacy clinical studies. In close relationship with these models, induced sputum and inflammatory cell counts will be addressed for phenotype-directed drug development. Additionally, important regulatory aspects regarding noninvestigational medicinal products
Energy-rich methane can be harnessed from seaweed deposits by anaerobic digestion. However, the high heavy metal content in the seaweed and its digestates limits their use as fertilisers. Heavy metal contaminants from solid seaweed can be removed by, mobilisation into a liquid phase and subsequent metal ions adsorption. In this laboratory-scale study, pretreatment strategies for enhancing seaweed
Background More effective prevention of suicide requires a comprehensive understanding of sociodemographic, psychiatric and somatic risk factors. Previous studies have been limited by incomplete ascertainment of these factors. We conducted the first study of this issue using sociodemographic and out-patient and in-patient health data for a national population. Method We used data from a national c
The rotation of water in noble gas matrices has been studied. It is shown that the rotation-translation coupling model of Friedmann and Kimel predicts rotation line spacings, which are close to the experimental observations for H2O, D2O, and HDO, when gas phase rotation constants are used. The model gives intensity estimates in reasonable agreement with the observations for the local oscillator ba
Sweden has experienced a national value-based pricing (VBP) system for innovative outpatient drugs operated by the Pharmaceutical Benefits Board - LFN (now called the Dental and Pharmaceutical Benefits agency - TLV) since 2002. VBP has the character of a monopoly system, leading to reimbursement decisions where usage of new medicines is limited to subgroups and not the population for which the dru
