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Background: Plasma copeptin, a marker of vasopressin, is associated with renal function decline in the general population. Our aim was to study the links between elevated copeptin and future risk of kidney disease.Methods: Copeptin was measured in a sample of the Malmö Preventive Project (MPP) Reinvestigation (n = 5158) and in the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC) (n = 5162). Ac
Looking at globular proteins with the eyes of a colloid scientist has a long tradition, in fact a significant part of the early colloid literature was focused on protein solutions. However, it has also been recognized that proteins are much more complex than the typical hard sphere-like synthetic model colloids. Proteins are not perfect spheres, their interaction potentials are in general not isot
Particulate air pollution is one of the major causes of premature death in the world, and combustion-derived soot emissions contribute strongly to the particulate pollution to which humans are exposed. Black carbon (BC) is one such emission and denotes soot with strong light absorption in the ultraviolet to infrared spectrum. Combustion can also generate brown carbon (BrC) particles, with absorpti
Hereditary cancer that has monogenic inheritance affects every tenth patient, on average, who is diagnosed with cancer, and it has been suggested based on twin studies, that approximately 30% of all cancer patients have a genetic predisposition to developing cancer. The author posited that familial syndromes become more organ specific with increasing age at tumour presentation to the point that ve
Extracellular vesicles (EVs) are derived from the membrane of platelets and released in the circulation upon activation or injury. Analogous to the parent cell, platelet derived EVs play an important role in hemostasis and immune responses by transfer of bioactive cargo from the parent cells. Platelet activation and release of EVs increases in several pathological inflammatory diseases, such as se
STUDY QUESTION: Which substances and signal transduction pathways are potentially active downstream to the effect of FSH and LH in the regulation of human oocyte maturation in vivo? SUMMARY ANSWER: The regulation of human oocyte maturation appears to be a multifactorial process in which several different signal transduction pathways are active. WHAT IS KNOWN ALREADY: Many studies in animal species
IMPORTANCE: Although occupational balance (OB) is a construct of importance to occupational therapy, existing OB assessments have not been validated in clinical populations. OBJECTIVE: To examine the validity and reliability of the 11-item version of the Occupational Balance Questionnaire (OBQ11) in U.S. adults with Type 1 diabetes. DESIGN: Data were analyzed from adults with Type 1 diabetes enrol
Enzymes have come into use for many new applications outside their natural biological environment, taking advantage of their high efficiency and selectivity as biocatalysts. Such new application often requires encapsulation to preserve the structure and activity of the enzyme, but also to regulate and control the activity. Here, we will discuss two types of encapsulation, soft matrices consisting
This research project aims to explore and theorize the role of the Market in a hyperviolence-endorsing consumer culture. How does the subaltern speak through “gangfluencers” in a Global North welfare society, and how do affective intensities of consumer desire enact the violent consumer subject herein?This research project aims to explore and theorize the role of the Market in a hyperviolence-endorsing consumer culture. How does the subaltern speak through “gangfluencers” in a Global North welfare society, and how do affective intensities of consumer desire enact the violent consumer subject herein?
BACKGROUND: There are important unmet clinical needs to develop cell enrichment technologies to enable unbiased label-free isolation of both single cell and clusters of circulating tumor cells (CTCs) manifesting heterogeneous lineage specificity. Here, we report a pilot study based on the microfluidic acoustophoresis enrichment of CTCs using the CellSearch CTC assay as a reference modality.METHODS
We utilize laser-induced breakdown spectroscopy for measuring mixture composition and temperature in flames. Spectroscopy of the plasma emission yields concentration information, while temperature is derived from the breakdown threshold pulse energy.
Möjligheten att korrigera den juridiska könstillhörigheten är en process som realiserades under 1970-talet i Sverige genom en specifik könstillhörighetslag. Lagen innebar en viss frigörelse för människor att själva bestämma vilken könsidentitet de identifierade sig med och skulle stå registrerade under i folkbokföringen. Som motprestation ställdes dock ett antal krav på de personer som ville korriThe ability to change the official gender identification was introduced in Sweden, by a particular law regulation, in the beginning of 1970s century. The law meant a certain liberation for people to, independently decide their one gender identity, and which official gender identification they required to get registered into. At the same time, the law also demanded a several conditions in return of
This thesis proposes an autoregressive credit spread model to make long term simulations of credit spreads and credit indices in the Investment grade and High yield bond segments. Several models are tested, and the final spread model produces simulations with statistics consistent with historical data, even though the model itself is relatively parsimonious. A transition from spread to index is pro
P>Aims Type 1 diabetes mellitus (T1DM) is an autoimmune disease with potential mechanistic links to immune-related cancers. We aimed at examining the overall and specific cancer risks among hospitalized T1DM patients from the national registers in Sweden. Methods A T1DM research cohort was created by identifying T1DM patients from the Hospital Discharge Register and linking them with the Cancer Re
Yoga can reduce blood pressure and has also been suggested to reduce inflammatory biomarkers and metabolic risk factors for cardiovascular diseases (CVDs). We aimed to assess the benefit of two yoga interventions on inflammatory biomarkers and metabolic risk factors in a high risk population in primary care.
Alcohol consumption contributes to many negative health consequences and is a risk factor for death. Some previous studies however suggest a J-shaped relationship between the level of alcohol consumption and all-cause mortality. These findings have in part been suggested to be due to confounders. The aim of our study was to analyze the relationship between self-reported alcohol intake and all-caus
Crisis management exercises sometimes produce weak or vague learning results with very limited applicability. This paper addresses these problems by developing a theoretical framework on learning from crisis management exercises. The framework focuses on necessary requirements and beneficial factors for the conceptual learning of individuals from discussion-based exercises. The variation theory of
Critical infrastructures provide services that are essential for the functioning of our society and extensive disruptions in these can have widespread effects. These effects are not only limited to the directly affected infrastructure but also indirectly through interdependencies to other infrastructures. By only account-ing for the direct consequences when analysing critical infrastructures, the
Background: Many older adults are physically inactive and inactivity increases with age. This knowledge comes from cross-sectional studies. Cross-sectional studies may miss important trajectories within the older adults as a result of retirements, and poor health impact of promotional efforts. The aim of this study was to analyse, longitudinally, the annual effects of age group and birth cohort on
