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Bladder cancer is a fast-moving and recurrent malignancy where survival hinges on early detection and precise risk stratification. The search for robust biomarkers is urgent, and CD44v6 has emerged as a compelling candidate. In this study, we explored the clinical and functional associations of CD44v6 expression in bladder cancer. Integrated analyses of patient samples and cell lines showed that h
This study is an effort to find a connection between the high number of people on sick leave, the occupational health situation at the workplace, and stronger market competition and globalisation forces. The basis for the study is statistics, mainly on injuries and diseases, interviews with people in different positions with either long experience within the safety and health situation or otherwi
The goal of this thesis is to answer the question what is the probability that the U.S. economy will experience a recession and a concomitant financial crisis in the near future. The question is answered through the use of a probit model, in which five explanatory variables, derived from previous research, are processed. The variables are Current Account to GDP, NYSE Composite Index, Domestic Cred
The credit rating industry is a complex and fascinating industry. Its history stretches back more than 150 years and has gradually increased in importance. During its history the dynamics of the industry have changed. The extended-principal-agent model was developed by synthesizing different principal-agent-relationships into one model. This model provides a holistic understanding of the credit ra
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Aerosols are one of the significant factors influencing climate, environment, and human health. They are categorized into anthropogenic and natural sources. In Sweden, natural aerosol sources of high coarse mode particle mass concentrations for particles larger than 1 µm in diameter include sea spray, primary biogenic particles, and dust particles. The dust particles can be agricultural soil and m
During the first few enzymatic turnovers after dark adaptation of photosystem II (PSII), the relaxation rate of the EPR signals from the Mn cluster and YD(dot) are significantly enhanced. This light-adaptation process has been suggested to involve the appearance of a new paramagnet on the PSII donor side [Peterson, Åhrling, Hogblom, and Styring, Biochemistry 2003, asap]. In the present study, a co
What research has been accomplished hitherto on the subject of anarchism within Islam? How has Islamic anarchism been approached and conceived by researchers and advocates? How might this field be approached? What are some of the challenges inherent in the study of anarchism in Islam? This chapter attempts to answer these questions while raising new ones. Work by Ahmet Karamustafa, Patricia Crone,
The book contains the first part of an investigation aimed at finding out why it is morally wrong (at least prima facie) to cause species to go extinct. That it is morally wrong seems to be a very basic and widely held intuition. It seems reasonable that a moral theory worth taking seriously ought to be able to account for that intuition. The most common attempt to answer our question is to refer
We previously discovered that high copeptin is associated with incidence of diabetes mellitus (diabetes), abdominal obesity, and albuminuria. Furthermore, copeptin predicts cardiovascular events after myocardial infarction in diabetic patients, but whether it is associated with heart disease and death in individuals without diabetes and prevalent cardiovascular disease is unknown. In this study, w
The c-myc proto-oncogene was analyzed in 311 cases of primary breast cancer, in 8% of which it was found to be amplified, usually at moderately increased copy number (2-5 copies). The adjacent pvt gene was co-amplified with c-myc in all tumors analyzed. C-myc amplification was significantly correlated to a high S-phase fraction and to amplification of the c-erbB-2 proto-oncogene. Weak relationship
Low-density polethylene disks with smooth or course surfaces were implanted in the abdominal wall of rats, and the tissue response was evaluated after 1, 6, or 12 weeks. Cell damage was detected by two different methods. Cells with increased membrane permeability could be identified using fluorescence microscopy by injection of propidium iodide prior to the killing of the rats. Second, cell death
It has been known for more than a century that neoplastic cells often exhibit disturbances of the mitotic process, but the causes have only recently been thoroughly explored. In many cancers, a combination of cell cycle checkpoint deficiency and abnormal shortening of telomeres predisposes to unbalanced chromosome segregation at cell division and the development of complex genomic rearrangements.
Chlorosis in crops grown on calcareous soil is mainly due to iron (Fe) deficiency and can be alleviated by leaf application of soluble Fe2+ or diluted acids. Whether chlorosis in indigenous plants forced to grow on a calcareous soil is also caused by Fe deficiency has, however, not been demonstrated. Veronica officinalis, a widespread calcifuge plant in Central and Northern Europe, was cultivated
The rise in the average temperature of earth has been described as global warming which is mainly attributed to the increasing phenomenon of the greenhouse effect. It is believed that global warming can have several harmful effects on human health, both directly and indirectly. Since malaria is greatly influenced by climatic conditions because of its direct relationship with the mosquito populatio
