Filtyp
Type II collagen (CII) is a candidate cartilage-specific autoantigen, which can become post-translationally modified by hydroxylation and glycosylation. T cell recognition of CII is essential for the development of murine collagen-induced arthritis (CIA) and also occurs in rheumatoid arthritis (RA). The common denominator of murine CIA and human RA is the presentation of an immunodominant CII-deri
This study explored the role of secreted fibroblast-derived factors in prostate cancer growth. Analyses of matched normal and tumor tissue revealed up-regulation of CXCL14 in cancer-associated fibroblasts of a majority of prostate cancer. Fibroblasts overexpressing CXCL14 promoted the growth of prostate cancer xenografts, and increased tumor angiogenesis and macrophage infiltration. Mechanistic st
The plasminogen activator (PA) system has been proposed to have important roles in rheumatoid arthritis. Here we have used the autoinumme collagen type II (CII)-induced arthritis (CIA) model and mice deficient for urokinase-type PA (uPA) or plasminogen to investigate the role of the PA system for development of arthritis. Our data revealed that uPA-deficient mice have a lower severity and incidenc
Climate change is a real challenge with global impacts in scope. The negative impacts of climate change are being experienced globally through raising temperatures, rising sea levels, melting ice and glaciers, extended drought and floods, soil erosion among others. The most vulnerable and affected by climate change are the developing countries that lack adaptive capacity to the impacts of climate
Understanding foreign policy changes has been an important part of academic research for decades. During the Cold War, when national security was at its most uncertain, we saw a focus on recognizing the patterns that could lead to changes in how a state approaches their foreign policy. In 2018 Imran Khan was elected prime minister in Pakistan along with his party Pakistan Tehreek-E-Insaf. Along ca
The objective of this paper is to examine the long-run relationship between CO2 emissions, economic output (GDP), and energy consumption in the US during the period 1960-2015. Energy consumption is investigated in its aggregated and disaggregated form i.e. Fossil Fuel, Nuclear, and Renewable energy to elicit a more precise diagnosis of the emission-energy-GDP nexus. The paper contributes to existi
Denna studie syftar till att utveckla ett analysverktyg för företag som överväger en reshoringstrategi. Trenden att återflytta produktion till ursprungslandet är ny, men växande och ett tomrum av teoretisk vägledning har funnits. Arbetet är av främst kvalitativ karaktär med fallstudier av svenska industriföretag som återflyttat verksamhet. Forskningsdesign kan liknas vid pattern matching (Yin, 201
The world of social media is here to stay, and while it offers plenty of opportunities for employers and organizations it is also said to be the biggest challenge for professional com-municators. Through employee advocacy, individuals can communicate the message of their organization to their whole network with merely the click of a button. But what makes the individual want to be an ambassador fo
MILJÖVETENSKAP Preliminärt schema 2022-10-05 Kurs: MVEN16 Klimatpolitik, samhällsstyrning och kommunikation, HT22 Kursansvarig: RH: Roger Hildingsson, Statsvetenskapliga inst; roger.hildingsson@svet.lu.se Lärare: CD: Carl Dalhammar, IIIEE; carl.dalhammar@iiiee.lu.se KH: Karl Holmberg, Statvetenskapliga inst; karl.holmberg@svet.lu.se JK: Jamil Khan, Miljö- och energisystemanalys, LTH; jamil.khan@mi
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/2022-10/Schema%20MVEN16%20HT22_PREL_5okt22%20v.2.pdf - 2026-07-23
BACKGROUND: There is mounting evidence that children born after in vitro fertilization (IVF) run an increased risk of neurological complications and notably cerebral palsy. Whether developmental disturbances occur more often than expected is debated. AIM: To investigate the risk for ADHD in children conceived after IVF. METHODS: Children conceived after IVF and born between 1982 and 2005 were iden
The importance of tyrosine residues in ligand-mediated endocytosis of the platelet-derived growth factor beta-receptor was analyzed using a series of tyrosine residue-mutated beta-receptors, which together cover all of the tyrosine residues in the juxtamembrane segment, the kinase insert, and the carboxyl-terminal tail; also certain of the tyrosine residues within the first and second parts of the
Aim: This study evaluates if accelerometer measured physical activity is related to higher composite risk factor scores for cardiovascular disease (CVD) in children. Methods: Cross-sectional study that included 223 children aged 7.9-11.1 years (boys n=123, girls n=100). Daily physical activity was assessed by accelerometers for four days. Body fat was quantified by dual x-ray absorptiometry. Maxim
The cytokine TGFβ1 induces epidermal Langerhans cell (LC) differentiation from human precursors, an effect mediated through BMPR1a/ALK3 signaling, as revealed from ectopic expression and receptor inhibition studies. Whether TGFβ1‒BMPR1a signaling is required for LC differentiation in vivo remained incompletely understood. We found that TGFβ1-deficient mice show defective perinatal expansion and di
The ESC diagnostic criteria for infective endocarditis (IE) added spondylodiscitis as minor diagnostic criterion. Of patients with Staphylococcus aureus, streptococcal or Enterococcus faecalis bacteremia, 11 of 1807 episodes were reclassified to definite IE of which nine were not treated as IE. Spondylodiscitis as a minor criterion decreases specificity of the criteria.
Recent studies of beetle specimens deposited in collections have revealed five species new to the Swedish fauna to be hiding amongst their closely related species. In some cases, the species known to the Swedish fauna are widespread and considered common, making it easy to overlook the slight differences that separate them from the similar and less common species. Some of these species are restric
