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Cholesterol-rich clusters of SNARE (soluble NSF attachment protein receptor) proteins have been implicated as being important for exocytosis. Here we demonstrate the significance of cholesterol for normal biphasic insulin secretion in mouse beta cells by removal of cholesterol from the plasma membrane using methyl-beta-cyclodextrin (MBCD). Maximal inhibition of insulin secretion in static incubati

Popular Abstract in English In this thesis I will compare and contrast two willow warbler subspecies, each with different migratory programs that meet in Central Sweden forming a migratory divide and hybrid zone. These migratory programs differ in the direction and distance traveled during migration. The "northern" willow warblers migrate south-southeast through the Balkan Peninsula to winter in eIn this thesis I will compare and contrast the two willow warbler subspecies (Phylloscopus trochilus trochilus and P. t. acredula) with differing migratory phenotypes (or "migratype") in the context of their migratory divide and hybrid zone in central Sweden. Their migratory programs differ in the direction and distance traveled during migration. The "northern" willow warblers migrate south-southe

BACKGROUND: [Corrected] Clinical assessment is not always sufficient to predict postoperative (PO) cardiac complications. B-type natriuretic peptide (BNP) has an important prognostic value in patients with heart failure. Its value as a predictor of events in orthopedic surgeries has not yet been tested.OBJECTIVE: To assess the value of BNP in predicting cardiac complications in the PO period of or

At the 100 years anniversary in 2020 of the Reunion around 650 memorials have been protected. The memorials are to be found all over Denmark, where they constitute the largest group. The time of their erection, the localization, design, inscriptions, pictures and initiators are relatively well known. The article investigates two main questions. Firstly, why have so many memorials for the Reunion b

We identified the gene encoding chondroitin-glucuronate C5-epimerase (EC 5.1.3.19 [EC] ) that converts D-glucuronic acid to L-iduronic acid residues in dermatan sulfate biosynthesis. The enzyme was solubilized from bovine spleen, and an ~43,000-fold purified preparation containing a major 89-kDa candidate component was subjected to mass spectrometry analysis of tryptic peptides. SART2 (squamous ce

The joint actions of animals in partnerships or social groups evolve under both natural selection from the wider environment and social selection imposed by other members of the pair or group. We used experimental evolution to investigate how jointly expressed actions evolve upon exposure to a new environmental challenge. Our work focused on the evolution of carrion nest preparation by pairs of bu

Cathelicidins are a family of antibacterial and lipopolysaccharide-binding proteins. hCAP-18, the only human cathelicidin, is a major protein of the specific granules of human neutrophils. The plasma level of hCAP-18 is >20-fold higher than that of other specific granule proteins relative to their levels within circulating neutrophils. The aim of this study was to elucidate the background for this

Yeast volatiles attract insects, which apparently is of mutual benefit, for both yeasts and insects. However, it is unknown whether biosynthesis of metabolites that attract insects is a basic and general trait, or if it is specific for yeasts that live in close association with insects. Our goal was to study chemical insect attractants produced by yeasts that span more than 250 million years of ev

Context: DevOps, the combination of Development and Operations, is a new way of thinking in the software engineering domain that recently received much attention. Given that DevOps is a new term and novel concept recently introduced, no common understanding of what it entails has been achieved yet. Consequently, definitions of DevOps often only represent a part that is relevant to the concept. Obj