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Partitioned polygenic scores (pPS) have been developed to capture pathophysiologic processes underlying type 2 diabetes (T2D). We investigated the association of T2D pPS with diabetes-related traits and T2D incidence in the Diabetes Prevention Program. We generated five T2D pPS (b-cell, proinsulin, liver/lipid, obesity, lipodystrophy) in 2,647 participants randomized to intensive lifestyle, metfor
Could the use of CSA practices stabilize the hunger crisis? Despite the general understanding that CSA practices increase farmers' food security, its resilience to climatic shocks is much less understood. To address this gap, this study analyzes the effect of three CSA practices: inorganic fertilization, intercropping and improved seeding on maize productivity in Ethiopia, Tanzania, and Uganda
This paper estimates labor supply effects for informal caregivers in Sweden using four waves of the SHARE data panel. To give daily or weekly care to a parent, step parent or parent in law is found to be more common among women than among men and is associated with lower employment probability for daily caregivers although the causal direction of the relationship is unclear. No negative effect of
Today, we live in an age that is continually witnessing tension, strife and terrorism as a direct product of unequal distribution of wealth and opportunities for a good life. In Uganda for over two and half decades, war, insurgency and deprivation have been the realities of the people living in Northern Uganda. This evidently has lead to an imbalance in the Ugandan society with the North standing
Background: There are known associations between cardiovascular disease (CVD)-related plasma proteins and spirometry measures. Diffusing capacity for carbon monoxide (DLCO) measures gas exchange that can be impaired both by lung and heart diseases. We aimed to study the associations between DLCO and CVD-linked plasma proteins in a population-based cohort without airflow obstruction. Methods: 89 CV
OBJECTIVE: Emergency department length of stay (EDLOS) is linked to crowding and patient outcomes whereas worse prognosis in low socioeconomic status remains poorly understood. We studied whether income was associated with ED process times among patients with chest pain.METHODS: This was a registry-based cohort study on 124,980 patients arriving at 14 Swedish EDs between 2015 and 2019 with chest p
X-rays allow to non-destructively investigate biological, chemical or physical processes at thenano-scale. Their high penetration depth in matter allows to investigate samples even in-side sample environments, which would be difficult with complementary methods such astransmission electron microscopy (TEM). The microscopy technique ptychography has beenestablished in X-rayX-rays allow to non-destructively investigate biological, chemical or physical processes at the nano-scale. Their high penetration depth in matter allows to investigate samples even inside sample environments, which would be difficult with complementary methods such as transmission electron microscopy (TEM). The microscopy technique ptychography has been established in X-ray imaging in recent year
B-lymphoblastic leukemia/lymphoma (B-ALL) is the most common pediatric malignancy and the most commonly diagnosed adult lymphoblastic leukemia. Recent advances have broadened the spectrum of B-ALL, with DUX4 gene fusions implicated in a subclass occurring in adolescents and young adults and harboring a favorable prognosis. DUX4 fusions have been challenging to identify. We aimed to determine wheth
Background: Previous studies have proposed growth differentiation factor-15 (GDF-15) as a predictor of adverse cardiovascular outcomes and mortality. The present study aimed to determine if such associations remain after accounting for death as a competing risk, and if GDF-15 provides superior prediction performance than other biomarkers. Methods: Plasma GDF-15 levels and cardiovascular risk facto
Regulation of development and entry into sporulation is critical for fungi to ensure survival of unfavorable environmental conditions. Here we present an analysis of gene sets regulating sporulation in the homothallic ascomycete Ashbya gossypii. Deletion of components of the conserved pheromone/starvation MAP kinase cascades, e.g., STE11 and STE7, results in increased sporulation. In kar3 mutants
Cyclin-dependent kinase 1 (Cdk1) is an archetypical kinase and a central regulator that drives cells through G2 phase and mitosis. Knockouts of Cdk2, Cdk3, Cdk4, or Cdk6 have resulted in viable mice, but the in vivo functions of Cdk1 have not been fully explored in mammals. Here we have generated a conditional-knockout mouse model to study the functions of Cdk1 in vivo. Ablation of Cdk1 leads to a
It has been suggested that those organizations which have greatest competitive success are those in which information systems strategy is seen as integral to overall business strategy. Thus, the CIO is seen as a full member of the management team, and not as someone presiding over a separate functional area which provides a service to the rest. There is a need therefore for businesses to avoid suc
This essay presents the contemporary research debate on if and how to regulate the use of PMSCs. Providing an extensive overview of the current arguments for and against the regulation of this market, this essay focuses specifically on the legal dimension of this question. Presenting arguments for and against new legislation in this area, the essay investigates the question of applicability of exi
