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Lys34 of the conserved translation elongation factor P (EF-P) is post-translationally lysinylated by YjeK and YjeA--a modification that is critical for bacterial virulence. Here we show that the currently accepted Escherichia coli EF-P modification pathway is incomplete and lacks a final hydroxylation step mediated by YfcM, an enzyme distinct from deoxyhypusine hydroxylase that catalyzes the final
This paper argues that conventional blame practices fall short of capturing the complexity of moral experiences, neglecting power dynamics and discriminatory social practices. It is evident that robots, embodying roles linked to specific social groups, pose a risk of reinforcing stereotypes of how these groups behave or should behave, so they set a normative and descriptive standard. In addition,
A drop of systemic blood pressure (BP) occurring shortly after individuals move from supine or seated position to upright posture with subsequent prompt spontaneous resolution is a common physiological occurrence in humans. If the induced hypotension is severe, lightheadedness or postural instability leading to falls and injury may occur. By consensus, a transient systolic BP drop >40 mmHg within
Data generated over nearly two decades clearly demonstrate the importance of epigenetic modifications and mechanisms in the pathogenesis of type 2 diabetes. However, the role of pharmacoepigenetics in type 2 diabetes is less well established. The field of pharmacoepigenetics covers epigenetic biomarkers that predict response to therapy, therapy-induced epigenetic alterations as well as epigenetic
Background: Not being able to work has negative health, social and financial consequences. Persisting breathlessness is prevalent in working-aged people. Is it associated with lower workforce participation? This study, using the South Australian Health Omnibus, aimed to explore associations between paid workforce participation and persisting breathlessness intensity, and economic impacts on income
The aim of this chapter is to analyse how the governing capacity of current policy instruments might be affected in futures of smart mobility. In order to explore this issue, the authors make use of the so-called NATO (nodality, authority, treasure, organisation) framework for analysing two contrasting scenarios. The analyses show that the overall governing capacity of many of the policy instrumen
TRAIN2WIND is a PhD TRAINing school analysing enTRAINment in offshore WIND farms with computer models and experiments. By its very nature, a wind turbine extracts energy from the wind, which is replenished from the wind field on the sides and above due to the ambient turbulence. However, offshore the turbulence is lower, and wind farms are typically larger than onshore, therefore the wind can only
Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can regulate neuronal excitability through interactions with ion channels2. Polyamines have been linked to pain, showing altered levels in human persistent pain states and mo
Bilaga 1 Verksamhetsberättelse 2017 för EDS Nordic User Group Vid EDS Nordic User Groups årsmöte 2017-03-22 i Luleå valdes följande styrelsemedlemmar: ordförande Cilla Öhnfeldt, Stockholms universitet (omval), Per Falk, Högskolan i Gävle (nyval), Ann- Christin Persson, Lunds universitet (nyval), Tove Andersson, Region Skåne (nyval), Mikael Arvidsson, Karlstads universitet (omval) och Eva Sejmyr, L
https://www.ub.lu.se/sites/ub.lu.se/files/verksamhetsberattelse_2017_for_eds_nordic_user_group.pdf - 2026-07-07
