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ABSTRACT: Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed. By studying animal models, reduced capacity of the NADPH-oxidase (NOX) complex, caused by a single nucleotide polymorphism (SNP) in one of its components (the NCF1 gene), has been found to
Ett alternativ till att investera i ett traditionellt inhouse-system är att hyra en tjänst eller ett system av en tredje part. Detta fenomen kallas för Software as a Service (SaaS). SaaS kan enligt litteraturen bidra med fördelar för företag i form av kostnadsbesparingar och korta implementeringstider. Men det finns också kritiker till SaaS som menar att det kan medföra säkerhetsbrister och minska
PET waste is the most visible environmental threat in the Maldives, a Small Island Developing State (SIDS). The thesis aims to propose the deposit refund system as a policy intervention, and evaluates the feasibility of introducing the system in the Maldives. In order to see how other SIDS have implemented the policy, the research uses policy evaluation framework to analyse the implementation mech
Under the growing influence of dominant discourses such as ecological modernisation and neo- liberalisation, proposed alternative conservation approaches focus more and more on efficiency. In the realm of biodiversity conservation, synthetic biology - the application of engineering to facilitate and accelerate the design or modification of genetic materials in living organisms – has emerged as an
There have been several accounts of suicide attacks in the last few years; and although male attackers outnumber female attackers, the number of female suicide bombers has been on the rise. This thesis analyzes the motivation of Muslim female suicide bombers using Durkheim’s theory on suicide and society. Interviews with experts on suicide and radicalization were conducted to provide a perspective
In this work the design of an experimental test Platform analysis of the mechanical behavior of car seats during passenger ingress and egress is presented. This development has been performed in two steps: the first Step is data acquisition. by means of a mat sensorized with a pressure gauge net and a photogrammetry system so as to acquire the movements performed by a human during ingress and egre
Invariant mass distributions of jet pairs (dijets) produced in LHC proton-proton collisions at a centre-of-mass energy root s = 7 TeV have been studied using a data set corresponding to an integrated luminosity of 1.0 fb(-1) recorded in 2011 by ATLAS. Dijet masses up to similar to 4 TeV are observed in the data, and no evidence of resonance production over background is found. Limits are set at 95
Intestinal spirochetes (Brachyspira spp.) are causative agents of intestinal disorders in animals and humans. Phylogenetic analysis of cloned 16S rRNA genes from biopsies of the intestinal mucosa of the colon from two Swedish 60-years old adults without clinical symptoms revealed the presence of intestinal spirochetes. Seventeen clones from two individuals and 11 reference strains were analyzed an
This study analysed the costs of median and ulnar nerve injuries in the forearm in humans and factors affecting such costs. The costs within the health-care sector and costs of lost production were calculated in 69 patients with an injury to the median and/or ulnar nerve in the forearm, usually caused by glass, a knife, or a razorblade. Factors associated with the variation in costs and outcome we
One of the target goals for sustainable development is the reduction of maternal mortality, which is a big health issue in some countries. Even if the research on maternal health care has come far and with the right expertise and supplies, almost all maternal deaths would be preventable. A working force to reduce the issues within maternal mortality in many countries are non-governmental organizat
Cambodia is now facing alarming issues concerning occupational safety and health in the construction sector. According to the ILO, in 2009, every day four people in Cambodia were killed due to occupational accidents which this amounted to more than 1500 death of the construction workers. Based on the union leaders in Cambodia, those accidents and illnesses were seen and occurred at the constructio
Searches for both resonant and nonresonant Higgs boson pair production are performed in the hh -> bb tau tau, gamma gamma WW* final states using 20.3 fb(-1) of pp collision data at a center-of-mass energy of 8 TeV recorded with the ATLAS detector at the Large Hadron Collider. No evidence of their production is observed and 95% confidence-level upper limits on the production cross sections are set.
This Letter presents the first search for a heavy particle decaying into an e(+/-)mu(-/+) final state in root s = 7 TeV pp collisions at the LHC. The data were recorded by the ATLAS detector during 2010 and correspond to a total integrated luminosity of 35 pb(-1). No excess above the standard model background expectation is observed. Exclusions at 95% confidence level are placed on two representat
A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9 fb(-1) collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of root s = 7 TeV. In the diphoton mass range 110-150 GeV, the largest excess with respect to the background-only hypothesis is
The summary of the present master thesis can be outlined as the following: The international terrorism and the counter-terrorism have been one of the biggest issues and concerns of the international community over the last decades. The international terrorism aims at the very destruction of human rights, democracy and the rule of law. There is no question and the debate that the international terr
Buildings account for 40% of energy use and about one third of CO2 emissions in the EU. The huge energy saving potentials offered by the building sector has been targeted by a large number of policy instruments. To improve policy intervention in this area, more information on the extent to which the applied policy instruments are supporting the development and dissemination of different types of e
Purpose: This work examined the feasibility of flattening filter free (FFF) volumetric modulated arc therapy (VMAT) for extreme hypofractionation of prostate cancer. The aim was to investigate the potential gain in treatment time per fraction for extreme hypofractionation of prostate cancer, while preserving or improving the treatment plan quality and radiation delivery quality. The impact of intr
