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A review of existing economic models in major depressive disorder (MDD) highlighted the need for models with longer time horizons that also account for heterogeneity in treatment pathways between patients. A core discrete event simulation model was developed to estimate health and cost outcomes associated with alternative treatment strategies.
A search is presented for photonic signatures motivated by generalized models of gauge-mediated supersymmetry breaking. This search makes use of 20.3 fb(-1) of proton-proton collision data at root s = 8 TeV recorded by the ATLAS detector at the LHC, and explores models dominated by both strong and electroweak production of supersymmetric partner states. Four experimental signatures incorporating a
This article discusses the prospects and limitations of the scientific basis for offering personalized nutrition advice based upon individual genetic information. Two divergent scientific positions are presented, with an ethical comment. The crucial question is whether the current knowledge base is sufficiently strong for taking an ethically responsible decision to offer personalized nutrition adv
An attractive option to produce chiral amines of industrial importance is through asymmetric synthesis using ω-transaminase. However, reaching high yields often requires a strategy for shifting the equilibrium position. This paper describes a novel strategy for handling this problem. It involves the use of a supported liquid membrane (SLM) together with a packed bed reactor. The reactor contains E
Dyskinesia and motor fluctuations affect up to 90% of patients with Parkinson's disease (PD) within ten years of L-DOPA pharmacotherapy, and represent a major challenge to a successful clinical management of this disorder. There are currently two main treatment options for these complications, namely, deep brain electrical stimulation or continuous infusion of dopaminergic agents. The latter is ac
AIMS: The sural nerve is the commonest peripheral nerve biopsied to help in the diagnosis of peripheral neuropathy of unknown cause. However, associated complications limit its use. The aim was, as an alternative, to asses biopsy of the terminal branch of the posterior interosseous nerve (PIN) in the forearm. METHODS: PIN pathology was morphometrically quantified in 10 male patients with Type 2 di
The study objective was to assess the effect of increased experience on complications in robotic hysterectomy for malignant and benign gynecological disease. This is a retrospective cohort study. It is a Canadian Task Force classification II-2 study conducted at the University Hospital, Sweden. The patients were 949 women planned for robotic hysterectomy for malignant (75 %) and benign (25 %) gyne
Det övergripande temat för boken är hur platser i allt högre utsträckning kommersialiseras och paketeras som en attraktiv produkt. I kapitlet exeplifieras dessa processer genom en skildring av hur olika aktörer inom den skandinaviska mötesindustrin paketerar och säljer in sina tjänster vid den årligen återkommande fackmässan i Stockholms mässhallar(SHIE). Samtidigt introduceras en deleuziansk händ
Efficient variability management is a key issue in large-scale product line engineering, where products with different propositions are built on a common platform. Variability management implies challenges both on requirements engineering and configuration management. This paper presents findings from an improvement effort in an industrial case study including the following contributions: problem
When developing products, engineering designers often face the problem that their candidate for a technical solution, ranging from a concept to a detailed design, needs to be analyzed by a design analyst before it is approved or rejected and the engineering designer can continue his/her activities within the product development process. If engineering designers have to send every solution candidat
Projects often suffer from lack of logistics considerations in the early phases. Since logistics is not the main focus of the people involved in the project, logistics solutions become reactive rather than proactive. With the increasing global competition, forcing companies to shorten time-to-market for their projects and becoming more cost effective, it becomes increasingly important to manage pr
Colonialism’ and ‘decolonization’ have been dealt with by postcolonial studies and, more recently, by scholars identified with the ‘de-colonial turn’. At the same time, in the ethnopolitically charged context of contemporary Bolivian society, colonialism and decolonization have become issues of political, existential and even cosmological import. This thesis identifies a need to root the ‘de-colon
Music in different forms is significant in young people's lives. In this presentation play is applied as a theoretical perspective to reach a deeper understanding of children’s musical learning and creativity. This presentation discusses findings from two empirical studies where children ages 6-8 years engage in musical activities: a doctoral a study (Nilsson, 2002) of nine 7-8-year-old Swedish ch
A search for doubly charged scalar bosons decaying into W boson pairs is presented. It uses a data sample from proton–proton collisions corresponding to an integrated luminosity of 36.1 fb- 1 collected by the ATLAS detector at the LHC at a centre-of-mass energy of 13 TeV in 2015 and 2016. This search is guided by a model that includes an extension of the Higgs sector through a scalar triplet, lead
Essentials Protein S and FV-Short are synergistic cofactors to Tissue Factor Pathway Inhibitor α (TFPIα). An assay for the TFPIα synergistic cofactor activity of protein S with FV-Short was developed. The assay was specific for the synergistic TFPIα-cofactor activity of free protein S. Protein S deficient individuals with known mutations were correctly distinguished from controls. Summary: Backgro
The transition to a Circular Economy (CE) requires enabling conditions that remove existing barriers in product life extension and material recovery operations. This contribution investigates barriers to material resource efficiency strategies in the maritime sector in Scandinavia and discusses the potential of policy interventions to enable increased reuse and remanufacturing of ship components.
