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Although biologics have revolutionized psoriasis treatment, they pose a significant burden on the healthcare budget. With the wide range of biologics available and the increasing number of biosimilars, insights into the real-world cost per responder (CPR) are required. Therefore, this study aims to evaluate the real-world CPR of adalimumab, ustekinumab, IL17-and IL23-inhibitors, incorporating both
Analyzing kinetic experiments on protein aggregation using integrated rate laws has led to numerous advances in our understanding of the fundamental chemical mechanisms behind amyloidogenic disorders such as Alzheimer's and Parkinson's diseases. However, the description of biologically relevant processes may require rate equations that are too complex to solve using existing methods, hindering mec
The establishment of innovation ecosystems has become an increasingly prevalent strategy for fostering territorial, economic and social development. However, the existing literature provides limited insights into the strategic conditions that enable the emergence of such ecosystems. This paper addresses this gap by identifying the critical elements and mechanisms underpinning their creation. Speci
Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship between chronic inflammation and habitual sleep duration is elusive. Here, we study this relation using genetically predicted level of chronic inflammation, indexed by CRP and IL6 signaling, and self-reported sleep duration. By Mendelian randomization analysis, we show that elevated CRP level within <10 mg
Context. Despite the ever-increasing number of known exoplanets, no uncontested detections have been made of their satellites, known as exomoons. Aims. The quest to find exomoons is at the forefront of exoplanetary sciences. Certain space-born instruments are thought to be suitable for this purpose. We show the progress made with the CHaracterising ExOPlanets Satellite (CHEOPS) in this field using
Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathological diagnosis are not available for most neurodegenerative neuropathologies. Here, we present ProtAIDe-Dx, a deep joint-learning model trained on 17,170 patients and controls that uses plasma proteomi
Building materials account for a high percentage of the non-land cost of self-help housing. Few studies, however, have examined the use of building materials by self-help builders and the practicalities of producing and distributing the materials in an alternative manner. This paper discusses the nature of construction by self-help in the intermediate-sized Colombian city of Pereira, focusing in p
The current framing of AI-driven technologies situates them as solutions to a looming care crisis. However, this overlooks informal caregivers' key role to current State budgetary deficits impacting healthcare services happening in Europe. As States increasingly rely on informal caregivers to provide care before the necessary involvement of healthcare services, there is already well-established re
Education is seen as a protective factor for refugee children (Gunton, 2007; Block et al., 2014). Evidences from countries with an extensive experience on refugee education show that the ability of schools to provide immediate and appropriate support is pivotal in order to favour a smooth accommodation process and ensure settlement, safety, and security for children (Bash, 2006; Porche et al. 2011
Refugees drown, are beaten, and are pushed back at the borders of the states of the Global North. Moral outrage is understandable in the face of such treatment. But does it constitute a good political theory? Can morality supply us with good normative arguments for a political world? In this article, I argue that they cannot. Drawing on political realism, I show why moral arguments for admitting r
In fixed-bed reactors, the use of large particles in thermally thick regimes is common, which underscores the need for a comprehensive understanding of intraparticle processes. However, integrating detailed particle models into fixed-bed simulations is computationally expensive. This study introduces a tabulation method for biomass conversion’s drying and pyrolysis stages, where significant mass e
In most manufacturing companies, it is necessary to carry inventory to a greater or lesser extent in order to disconnect the activities in the supply chain that are not conducted at the same pace. This way, a smoother flow through the chain, from raw material extraction to arrival at the final customer of a finished product, is facilitated. However, different parts of a company often have conflict
The studied intrusion, the Hakefjorden Complex on Älgön is a norite-anorthosite complex situated in the archipelago on the west coast of Sweden. The origin of the intrusion will be deduce through in situ Sr-isotope analysis by MC-ICP-MS (multiple collector- inductively coupled plasma- mass spectrometry) on plagioclase, together with petrographic description and chemical analysis. The examined plag
Abstract On May 18th in Abu Dhabi, UAE, IRENA released a report declaring that Djibouti can meet 100% of energy demand through renewable energy sources by 2020. Today, 55% of the population lives without access to electricity, 60% is unemployed, and the country depends greatly on imports of energy sources, inter alia fossil fuels and electrical power, which contribute to the continued rising leve
A grant back obligation refers to the obligation for a licensee to assign or license future developed improvements to a licensor. Grant back clauses affect on competition has been a controversial subject in economic and legal doctrine. The study answers if the changed approach in the European Union towards the separation of severable and nonseverable improvements in relation to grant back clauses
The purpose of this study is to examine whether an acquiring firm that operates as a contractor within the defence sector can expect to generate shareholder value from a merger and acquisition with a fellow defence sector competitor. Having selected thirty acquiring defence firms an event study utilizing the market model is performed to obtain the abnormal returns generated from a merger and acqui
The debt equity bias refers to the discrimination between debt and equity finance. This discrimination is problematic since it distorts companies’ decisions and increases systemic risk. The European Commission has recommended Sweden to eliminate or reduce the bias and the Swedish Ministry of Finance has gathered a committee to investigate possible solutions. Sørensen (2010) suggested that Sweden w
