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Although biologics have revolutionized psoriasis treatment, they pose a significant burden on the healthcare budget. With the wide range of biologics available and the increasing number of biosimilars, insights into the real-world cost per responder (CPR) are required. Therefore, this study aims to evaluate the real-world CPR of adalimumab, ustekinumab, IL17-and IL23-inhibitors, incorporating both
Analyzing kinetic experiments on protein aggregation using integrated rate laws has led to numerous advances in our understanding of the fundamental chemical mechanisms behind amyloidogenic disorders such as Alzheimer's and Parkinson's diseases. However, the description of biologically relevant processes may require rate equations that are too complex to solve using existing methods, hindering mec
The establishment of innovation ecosystems has become an increasingly prevalent strategy for fostering territorial, economic and social development. However, the existing literature provides limited insights into the strategic conditions that enable the emergence of such ecosystems. This paper addresses this gap by identifying the critical elements and mechanisms underpinning their creation. Speci
Winter is a critical bottleneck period for many insects and is particularly pivotal for pest species, being a major regulator of their populations. In winter, insect fruit pests such as the invasive fly, Drosophila suzukii, not only have to cope with harsh environmental conditions but also need to find alternative resources when cultivated fruit are scarce. This study aimed to disentangle the rela
Statistical combinations of searches for charginos and neutralinos using various decay channels are performed using 139 fb^{-1} of pp collision data at sqrt[s]=13 TeV with the ATLAS detector at the Large Hadron Collider. Searches targeting pure-wino chargino pair production, pure-wino chargino-neutralino production, or Higgsino production decaying via standard model W, Z, or h bosons are combine
Imbalances in dopamine activity significantly contribute to the pathophysiology of several neuropsychiatric disorders, including addiction, ADHD, schizophrenia, impulse control disorders, and Parkinson's Disease. Neuro(active)steroids, comprising endogenous steroids that finely modulate neuronal activity, are considered crucial regulators of brain function and behavior, with implications in variou
There is increasing recognition of the role that artificial intelligence (AI) systems can play in managing health crises. One such approach, which allows for analysing the potential consequences of different policy interventions is agent-based social simulations (ABSS). Here, the actions and interactions of autonomous agents are modelled to generate virtual societies that can serve as a “testbed”
IntroductionAbout two thirds of in-hospital deaths following successful resuscitation aftercardiac arrest are due to hypoxic-ischaemic brain injury. (1,2) Most occur after adecision to withdraw from life sustaining therapy (WLST) in patients wheremeaningful neurological recovery is unlikely. (2) In 2021 the EuropeanResuscitation Council (ERC) and the European Society of Intensive Care Medicine(ESI
ALADDIN is a proposed fixed-target experiment at the LHC for the direct measurement of charm baryon dipole moments. The detector features a spectrometer and a Cherenkov detector, while the experimental technique is based on the phenomena of particle channelling and spin precession in bent crystals. TWOCRYST, a proof-of-principle test at the LHC for the proposed experiment, is planned during the LH
The short-time iterative adaptive approach is a spectral estimation alternative to the short-time Fourier transform for non-stationary vibration analysis. This technique offers a reduction in leakage effects and a higher resolution in exchange for a higher computational complexity. The short-time iterative adaptive approach can be summarized as a high-resolution data-dependent approach which has b
This article is about finding the limit set for banded Toeplitz matrices. Our main result is a new approach to approximate the limit set Λ(b), where b is the symbol of the banded Toeplitz matrix. The new approach is geometrical and based on the formula Λ(b) = ∩ρ∊(0, ∞) sp T (bρ), where ρ is a scaling factor, i.e., bρ(t):= b(ρt), and sp(∙) denotes the spectrum. We show that the full intersection ca
Despite the widely recognized potential of product-as-a-service (PaaS) business models to contribute to the circular economy, many industrial case studies have reported that several systemic factors tend to hinder product manufacturers from effectively designing such solutions. More specifically, factors such as linear value chains, organizational structures, and market and financial conditions te
The impacts of climate change may be particularly severe for geographically isolated populations, which must adjust through plastic responses or evolve. Here, we study an endangered Arctic plant, Primula nutans ssp. finmarchica, confined to Fennoscandian seashores and showing indications of maladaptation to warming climate. We evaluate the potential of these populations to evolve to facilitate sur
IntroductionResearch evidence suggests that radiographers often rely on previous training, traditional practices, work experience and protocols developed within the department rather than up-to-date research-based evidence in their daily practice. The aim of the study was to investigate factors that might impact the development of evidence-based practice amongst radiographers in clinical public se
Cytidine triphosphate synthetase (CTPS) is a key enzyme in nucleic acid and phospholipid biosynthesis and its activity is increased in certain human cancers, making it a promising drug target. The crystal structure of the synthetase domain of human CTPS, which represents the first structure of a CTPS from an eukaryote, has been determined. The structure is homotetrameric and each active site is fo
To address environmental and climate issues, alternative technologies to fossil resources are sought after, both for the production of fuels and of chemicals. Algae appear as an attractive solution and have applications in the food, feed, energy or chemistry at large. A study funded by ADEME and conducted by ENEA, a consulting firm for energy and sustainable development for the industrial sector,
Solar-driven photocatalytic green hydrogen (H2) evolution reaction presents a promising route toward solar-to-chemical fuel conversion. However, its efficiency has been hindered by the desynchronization of fast photogenerated charge carriers and slow surface reaction kinetics. This work introduces a paradigm shift in photocatalyst design by focusing on the synchronization of charge transport and s
Welcome to the fifth edition of the REWBAH workshop, a satellite event of the IEEE International Requirements Engineering Conference (RE). The REWBAH workshop fosters discussion related to requirements engineering resulting from the need to build software systems that not only support healthcare, but also promote well-being, encourage patients and the population in general to live according to hea
Universities are expected to play a proactive role in the sustainable development andtransformation of their regions. However, they face external and internal barriers toplay that role. One possible approach to overcome those barriers is through trans-formative academic institutions (TAIs). TAIs are defined as research centres createdwithin universities to proactively engage in territorial develop
This paper presents a methodology to fully characterize the dynamic range of a linear X-ray detector, usually employed to perform radiography and tomography. The proposed procedure analyzes each pixel of the detector and presents the results both in terms of general performance of the detector and as a spatial distribution of different parameters for each pixel. This method has been applied to thr
