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Up to this date, only a few silk hydrogels were reported to be injectable. Of these, none are truly biomimetic, and are instead comprised of blends with limited amounts of silk. Hence, no truly silk-based hydrogels exist as of today. From the reported injectable matrices, only a few have considered the natural progressive acidification to which silk proteins are exposed before spinning. Adding to

Amyloid-β (Aβ) positron emission tomography (PET) imaging and cerebrospinal fluid (CSF) biomarkers are now established tools in the diagnostic workup of patients with Alzheimer's disease (AD), and their use is anticipated to increase with the introduction of new disease-modifying therapies. Although these biomarkers are comparable alternatives in research settings to determine Aβ status, biomarker

Organizations may be confronted with both expected and unexpected events that challenge their abilities to provide these services uninterrupted. Traditional strategies based on anticipation and planning are primarily useful for expected events, but for unexpected events, organizations must develop capacities to adapt to situations and conditions not foreseen. As systems and societies are becoming

We use individual-level income data from archived taxation lists to study top-income earners in Sweden from 1909 to 1950. Using information on 21,055 individual taxpayers in two elite areas in greater Stockholm, we show that top incomes fell in real terms over this period, at a stable pace without obvious connection to the Great Depression or the world wars. The peak of inequality was related to t

In the software industry, the drive to add new features often overshadows the need to improve existing code. Large Language Models (LLMs) offer a new approach to improving codebases at an unprecedented scale through AI-assisted refactoring. However, LLMs come with inherent risks such as braking changes and the introduction of security vulnerabilities. We advocate for encapsulating the interaction

Background: Testicular torsion (TT) is a scrotal emergency that needs urgent detection for successful treatment. Purpose: To investigate the diagnostic value of acute ultrasound and the possibility of more effective detection. Material and Methods: This retrospective study included patients assessed with ultrasound for suspicion of TT between 2019 and 2023. Registration of parameters included symp

Pixel sensors in 3D technology equip the outer ends of the staves of the Insertable B Layer (IBL), the innermost layer of the ATLAS Pixel Detector, which was installed before the start of LHC Run 2 in 2015. 3D pixel sensors are expected to exhibit more tolerance to radiation damage and are the technology of choice for the innermost layer in the ATLAS tracker upgrade for the HL-LHC programme. While

A magainin derivative, designated MSI-344, was produced in Escherichia coli as fusion protein, by utilizing a truncated amidophsphoribosyltransferase of E. coli as a fusion partner. Bacterial cells transformed with the gene encoding the fusion protein were grown to a high cell density and induced with isopropyl-1-thio-b-D-galatoside (IPTG) to initiate product expression. The fusion protein was

Pregnant women have historically and are currently being excluded from cervical cancer screening in most low and middle-income countries (LMICs). The aim of this study was to assess the feasibility and outcomes of including pregnant women in a HPV self-sampling-based screening program in Ethiopia. Pregnant women, recruited from a previously established cohort, were included. They answered a questi

Background: Geant4, a Monte Carlo Simulation Toolkit extensively used in bio-medical physics, is in continuous evolution to include newest research findings to improve its accuracy and to respond to the evolving needs of a very diverse user community. In 2014, the G4-Med benchmarking system was born from the effort of the Geant4 Medical Simulation Benchmarking Group, to benchmark and monitor the e

Hydrogen-fuelled technologies for home heating and cooking may provide a low-carbon solution for decarbonising parts of the global housing stock. For the transition to transpire, the attitudes and perceptions of consumers must be factored into policy making efforts. However, empirical studies are yet to explore potential levels of consumer heterogeneity regarding domestic hydrogen acceptance. In r

A summary of the constraints from searches performed by the ATLAS collaboration for the electroweak production of charginos and neutralinos is presented. Results from eight separate ATLAS searches are considered, each using 140 fb−1 of proton-proton data at a centre-of-mass energy of s = 13 TeV collected at the Large Hadron Collider during its second data-taking run. The results are interpreted in

Proteins and peptides are vital biomolecules, and deuterated amino acids are increasingly applied in areas such as drug discovery, metabolic tracing, and neutron scattering studies. In this study, we performed deuteration on all 20 proteinogenic amino acids, including their side chains, and established efficient methods for 13 amino acids. Using a Pt/C-catalyzed hydrogen–deuterium exchange reactio

The retinoblastoma gene (RB1), which is located on chromosome 13q14.2, is mutated in retinoblastoma (RB), the most common malignant intraocular tumor in children. About 8000 new cases of retinoblastoma are diagnosed globally each year, accounting for approximately 1 in 17,000 live births. RB is prototypically considered hereditary by nature as thirty to forty percent of cases have autosomal domina

The Cherenkov Telescope Array (CTA) is the future observatory for ground-based imaging atmospheric Cherenkov telescopes. Each telescope will provide a snapshot of gamma-ray induced particle showers by capturing the induced Cherenkov emission at ground level. The simulation of such events provides camera images that can be used as training data for convolutional neural networks (CNNs) to differenti

Dopaminergic neurons in the ventral midbrain are critical for regulating movement, cognition, and emotion. Ventral midbrain organoids can be used to model both development and diseases of the dopaminergic system, especially Parkinson’s disease. Here, we summarize recent advances and remaining challenges in developing such three-dimensional organoids from human pluripotent stem cells. We outline ho