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□ Total hip arthroplasty (THA) registers are established in several countries to collect data aiming to improve the results after THA. Monitoring of adverse outcomes after THA has focused mainly on revision surgery, but patientreported outcomes have also been investigated. □ Several surgery-related factors influencing the survival of the THA have been thoroughly investigated and have changed clini
This case study on the dark side of communication and place branding explores the Amazon corporation’s highly-publicized competitive search for a city to become their second headquarters (dubbed HQ2). In 2017 Amazon sent an open Request for Proposals (RFP) to cities in North America defining what constitutes an ‘ideal’ headquarters. In addition to offering capital and incentives, Amazon’s ideal ci
The resurgence of artificial intelligence (AI) has empowered organizations to concentrate their research efforts on enhancing decision-making and automation capabilities. This is being pursued with the goal of increasing productivity, whilst reducing costs. With this, it is perceived that the jobs within these organizations that are considered subject to ‘routine’, or repetitive and mundane tasks,
The Advanced Light Source (ALS) at Berkeley Lab has seen many upgrades over the years, keeping it one of the brightest sources for soft x-rays worldwide. Recent developments in magnet and vacuum technology, as well as lattice design (multi bend achromat lattices) appear to open the door for very large further increases in brightness [1]. This could be achieved by reducing the horizontal emittance,
The intensification of agricultural practices throughout the twentieth century has had large detrimental effects on biodiversity and these are likely to increase as the human population rises, with consequent pressure on land. To offset these negative impacts, agri-environment schemes have been widely implemented, offering financial incentives for land-owners to create or maintain favourable habit
The pancreatic islets in obese-hyperglycemic mice display a normal response of insulin secretion when stimulated with glucose in vitro. This indicates that the impaired glucose metabolism is due to extra-pancreatic factors rather than to deficient β-cell function. In fact, the pancreas of these mice is a useful source from which to isolate large numbers of mammalian β-cells suitable for studies of
Purpose: The purpose of this paper is to elaborate on how perspectives and assumptions embedded in the complexity paradigm contribute to make logistics management research better aligned with real-life logistics. This is necessary, due to increasing supply chain complexity caused by an increasing request for sustainable development (SD). Design/methodology/approach: The research is exploratory and
The minimum weighted edge dominating set problem (MWEDS) generalizes both the weighted vertex cover problem and the problem of covering the edges of graph by a minimum cost set of both vertices and edges. In this paper, we propose a meta heuristic approach based on genetic algorithm and local search to solve the MWEDS problem. Therefore, the proposed method is considered as a memetic search algori
Lawrence Summers produced a big upset within the economics profession when he revived Alvin Hansen’s theory of secular stagnation, which had been thought of as an old-Keynesian fallacy. While some economists like Brad DeLong and Paul Krugman instantly recognized Summers’s contribution, a large share of the economics profession remained skeptical at first. Whereas most New Keynesian models allow fo
The Davies transformation is a method to transform the steering vector of a uniform circular array to another vector with Vandermonde form. However, this transformation can be highly sensitive to perturbations of the underlying ideal array model. In this paper, we describe a method for deriving a more robust transformation using optimisation techniques. The effectiveness of the method is illustrat
A circular economy has been proposed as a sustainable alternative to our current linear economic system, mainly by recirculating material resources for new product development. To understand resource recirculation in practice, this paper analyses over 50 examples of products developed from discarded materials, categorising them into the recovery routes described in the circular economy literature.
A large Time Projection Chamber is the main device for tracking and charged-particle identification in the ALICE experiment at the CERN LHC. After the second long shutdown in 2019/20, the LHC will deliver Pb beams colliding at an interaction rate of about 50 kHz, which is about a factor of 50 above the present readout rate of the TPC. This will result in a significant improvement on the sensitivit
The European Spallation Source is being constructed in Lund, Sweden and is planned to be the world's brightest pulsed spallation neutron source for cold and thermal neutron beams (≤ 1 eV). The facility uses a 2 GeV proton beam to produce neutrons from a tungsten target. The neutrons are then moderated in a moderator assembly consisting of both liquid hydrogen and water compartments. Surrounding th
In this discussion paper, we outline and reflect on some of the key challenges that influence the development and uptake of more inclusive and responsible forms of research and innovation. Taking these challenges together, we invoke Collingridge’s famous dilemma of social control of technology to introduce a complementary dilemma that of ‘societal alignment’ in the governance of science, technolog
Imaging through turbid environments is experimentally challenging due to multiple light scattering. Structured laser illumination has proven to be effective to minimize errors arising from this phenomenon, allowing the interior of optically dense media to be observed. However, in order to preserve the image spatial resolution while suppressing the intensity contribution from multiple light scatter
Background: Effective digestive enzymes are crucial for successful islet isolation. Supplemental proteases are essential because they synergize with collagenase for effective pancreatic digestion. The activity of these enzymes is critically dependent on the presence of Ca2+ ions at a concentration of 5–10 mM. The present study aimed to determine the Ca2+ concentration during human islet isolation
BACKGROUND: The Self-Reported Foot and Ankle Score (SEFAS) is a foot- and ankle-specific patient-reported outcome measurement (PROM) score that has been validated with good results for a variety of foot and ankle disorders. SEFAS is sensitive detecting improvement or deterioration after surgery. However, normative values, required to put a specific patient's summary score into perspective, are lac
We developed a novel analytical method for concentration determination of tandem single-chain antibody diphtheria toxin (immunotoxin). The method is based on polymethacrylate monoliths with Protein L ligands as the binding moiety. Different buffers were tested for elution of the Protein L-bound immunotoxin and 4.5 M guanidinium hydrochloride performed best. We optimized the elution conditions and
