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Cell type deconvolution - the computational estimation of cellular composition in bulk tissue samples - is a valuable tool in cancer research for understanding immune infiltration and tissue heterogeneity. Most deconvolution algorithms infer the composition of cell types in bulk samples by modeling the observed expression data as a linear combination of reference expression profiles from each cell
Household expenditure patterns in Ukraine were explored with a focus on clustering techniques to uncover socioeconomic insights and inform policy interventions. Using an officially published Household Income Survey dataset for 2021, the research applies advanced machine learning models, including k-means, DBSCAN, and PCA, to analyze spending habits and identify household profiles with distinct exp
This thesis critically examines the Swedish ‘Security Zones’ legislation, the associated governmental discourse on organised criminality, and their implications for equality and racial justice. Through a critical discourse analysis, the thesis illustrates how the extended discretion afforded through the legislation facilitates law enforcement’s capacity for racial profiling and discrimination. It
Problem Statement: Sandvik Rock Processing is in the need for a classification tool, which can help them improve their inventory management. Currently, there are problems with inefficiencies with deficit as well as excess in inventory. The new classification shall the basis for the differentiation of service levels and facilitate a shared view on items’ importance. Purpose: The purpose of this th
This thesis explores the visual and cultural representation of worldbuilding in fantasy genre video game trailers. The focus is to find out to what extent video game trailers in the fantasy genre utilise visual tropes and cultural representations to establish an identity as fantasy video games. It is well established that game developers look for inspiration in the real world when creating new one
Policy Coherence for Development is a concept, framework and tool for achieving a more effective and organized global development agenda. Under the principles of Policy Coherence for Development (PCD), the potential conflicts of objectives between various policy areas should be identified and preferably resolved – with developmental objectives in mind. The PCD has named some policy areas as “expec
Thesis purpose: The purpose of this study is to gain knowledge about baby boomers’ motivations for using either digital or analogue touchpoints in the high involvement customer journey. This ultimately contributes to an increased understanding of the high involvement customer journey. Methodology: A qualitative study with social constructionism as the research philosophy, where an abductive appro
Styvhetsförändringar i bröstvävnad är ofta kopplade till en patologisk förändring. Vissa cancertyper som infiltererande duktalt carcinom kan vara åtta gånger så styv som fettvävnaden runt omkring. Genom att komprimera bröstet och mäta trycket på bröstets yta har man identifierat att det blir en lokal förhöjning i tryck där det finns en tumör. Med hjälp av den här typen av mekanisk avbildning av brA change in stiffness of breast tissue is often connected to a pathological change. Some types of breast cancer such as infiltrating ductal carcinoma can be up to eight times stiffer than fat tissue. It has been found that during compression of the breast there will be a local area of relatively high stress at the breast surface at the location of a tumour. This type of mechanical imaging of the b
Since their emergence in the 1950’s, ice cores have ventured from being scientific objects of concern to a limited number of glaciologists to becoming one of the most iconic representations of anthropogenic climate change. This thesis aims to historicize the way in which ice cores became enrolled into climate discourse, particularly emphasizing the production and representation of temporalities of
Japan continuously attempts to reinterpret war-renouncing Article 9 while at the same time stressing its devotion to pacifism, most recently through the Legislation for Peace and Security. The new Legislation allows Japan to engage in collective self-defense, which was considered unconstitutional for 70 years. This thesis examines Japan’s legitimization of such change, answering the question; how
Cross-functional teams and meetings are recurrent structuring tools in contemporary knowledge organisations. They are recommended as solutions to enhance innovation and creativity. Current research gathers a myriad of reference to the benefits of such tools, but studies of their potential negative effects remain limited. This paper is specifically concerned with the effect of interdisciplinary tea
Background: Omni-channel retailing has led to customers becoming more demanding and less tolerant than before. For instance, customers are demanding shorter delivery times, and higher precision in deliveries. Unless retailers adapt to an omni-channel approach today, their business is likely to suffer. To do so, more efficient planning of the supply chain is necessary. The first step of the plannin
The many-body problem in quantum mechanics always presents new challenges and ways to discover new properties of existing materials. The difficulty (if not the impossibility) to solve the many-body problem analytically makes the numerical methods an appealing approach. Here we consider a Python code, which is under development to become an open-source tool to perform studies of finite lattice syst
Inflammation and subsequent endothelial dysfunction are main players in the vascular component of hypertension, and recent findings points to a key role of Sphingosine- 1-Phosphate and its signaling pathways in its pathophysiology. In neurodegenerative disorders such as Alzheimer’s disease, hypertension is the main modifiable risk factor, but insights regarding S1P receptor modulation in response
This Master Thesis aims to show an approach to the design of parallel robots,specifically the development of its kinematics. To do this, screw theory will be used, focusing on its theoretical bases and taking it later to practice. First, a theoretical definition of the inverse and forward kinematics of a parallel robot is carried out. Subsequently, algorithms are generated in Python that verify t
In this thesis, a new probabilistic risk assessment tool for road tunnels has been verified and validated. The verification and validation were performed along with a literature review to find different key variables that affect the risk in a road tunnel and find out how these variables can be handled. Examples of variables are heat release, ventilation mode and factors within evacuation modelling
Digitalisering är utan tvekan 2000-talets viktigaste bidragande orsak till utvecklingen av den globala ekonomin. Skatteplanering och skatteflykt bland multinationella bolag urholkar nationers skattebas som finansierar det offentliga välfärdssystemet såsom sjukvård, utbildningsinstitutioner och infrastruktur. Digitala affärsmodeller genererar intäkter annorlunda än traditionella affärsmodeller ocDuring the 21th century, digitalization is considered the most important development of the modern global economy. Tax avoidance is a growing issue for governments globally, that are loosing lots of tax money to finance public welfare systems supporting healthcare, educational institutions and infrastructures. Value creation in digital business models generates profits different than traditional b
In the field of computational biology, fluorescence microscopy images often constitute the input source of information. The process of binarization of raw images to delineate interesting objects requires image segmentation into signal and background pixels. Several methods to perform image segmentation exist, the Otsu method being a popular unsupervised example. The Otsu method's lack of pro
Globalization has led to the emergence of global value chains (GVCs) and most of the world’s trade is now in intermediate inputs. This has raised questions about employment in GVCs and attracted the interest of researchers and policymakers alike, but is difficult to study empirically. This paper investigates job creation in simple and complex GVCs for 43 economies between 2000 and 2014 on the basi
Due to increasing awareness and consumer demands it has become important for companies to develop an economical and environmentally sustainable alternative to traditional petroleum-based plastics. The transition from fossil material to bio based is important for the future of people and planet, still, how the transformation should be implemented is yet unknown. In this report, the possibilities of
